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Branching in Nature pp 257–280Cite as

Vascular Development: Design Principles and Morphometric Analysis of a Branched Vascular Tree

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Part of the book series: Centre de Physique des Houches ((LHWINTER,volume 14))

Abstract

The formation of new blood vessels is an important process in embryonic development and in (patho) physiological conditions like cyclic vessel growth in the endometrium, wound healing, diabetic retinopathy, and tumor growth. Lack of blood vessel growth is a key event in pathologies like essential hypertension, peptic ulcers, and bowel atresia. At present clinical trials are undertaken with anti-angiogenic drugs to interfere with tumor development [2, 3, 7, 14, 19]. Pro-angiogenic therapies, or “therapeutic angiogenesis” are employed in the treatment of ischemia related events such as coronary artery disease (“infarction”) and peripheral artery occlusive diseases [11, 20, 56, 59, 67]. This therapy aims at stimulation of collateral artery formation to the ischemic region thereby restoring flow and oxygen delivery.

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Authors
  1. F. le Noble
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  2. W. Hacking
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  3. D. Slaaf
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  4. H. Struijker-Boudier
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Editor information

Editors and Affiliations

  1. Laboratoire de Physique de la Matière Condensée, École Polytechnique, 91128, Palaiseau Cedex, France

    Vincent Fleury  & Jean-François Gouyet  & 

  2. Laboratoire de Physique des Solides, Université Paris-Sud Orsay, 91405, Bâtiment 510, Orsay, France

    Marc Léonetti

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le Noble, F., Hacking, W., Slaaf, D., Struijker-Boudier, H. (2001). Vascular Development: Design Principles and Morphometric Analysis of a Branched Vascular Tree. In: Fleury, V., Gouyet, JF., Léonetti, M. (eds) Branching in Nature. Centre de Physique des Houches, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06162-6_15

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  • DOI: https://doi.org/10.1007/978-3-662-06162-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41888-7

  • Online ISBN: 978-3-662-06162-6

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