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The Effect of Aprotinin on Platelet Function and Coagulation In Vitro

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Blood Use in Cardiac Surgery
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Abstract

Aprotinin is associated with an impressive reduction in postoperative blood loss after cardiac surgery [1]. The risk of transmission of infection with homologous blood transfusion has led to the call for the use of haemostatic agents, such as aprotinin, routinely during cardiopulmonary bypass [2]. There is concern however, that the haemostatic effect of the drug may reflect its thrombogenic potential and therefore, preclude its routine use.

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References

  1. Bildstrup BP, Royston D, Sapsford RN, Taylor KM (1989) Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol). J Thorac Cardiovasc Surg 97: 364–373

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  2. Ferraris VA, Gildengorin V(1989) Predictors of excessive blood use after coronary artery bypass grafting. J Throac Cardiovasc 98: 492–497

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  3. Gorog P, Kovacs IB (1990) Modelling coronary thrombosis from non-anticoagulated human blood in-vitro. Haematologic Pathology 4(1): 43–52.

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  4. Kovacs IB, Hutton RA, Kernoff PBA (1989) Haemostatic evaluation in bleeding disorders from native blood. Clinical experience with the Haemostatometer. Am J Clin Pathol 91: 271–179

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© 1991 Springer-Verlag Berlin Heidelberg

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Ratnatunga, C.P., Gorog, P., Kovacs, I.B., Ress, G.M. (1991). The Effect of Aprotinin on Platelet Function and Coagulation In Vitro. In: Friedel, N., Hetzer, R., Royston, D. (eds) Blood Use in Cardiac Surgery. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-06119-0_6

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  • DOI: https://doi.org/10.1007/978-3-662-06119-0_6

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-06121-3

  • Online ISBN: 978-3-662-06119-0

  • eBook Packages: Springer Book Archive

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