Abstract
Aprotinin is associated with an impressive reduction in postoperative blood loss after cardiac surgery [1]. The risk of transmission of infection with homologous blood transfusion has led to the call for the use of haemostatic agents, such as aprotinin, routinely during cardiopulmonary bypass [2]. There is concern however, that the haemostatic effect of the drug may reflect its thrombogenic potential and therefore, preclude its routine use.
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References
Bildstrup BP, Royston D, Sapsford RN, Taylor KM (1989) Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol). J Thorac Cardiovasc Surg 97: 364–373
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Kovacs IB, Hutton RA, Kernoff PBA (1989) Haemostatic evaluation in bleeding disorders from native blood. Clinical experience with the Haemostatometer. Am J Clin Pathol 91: 271–179
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© 1991 Springer-Verlag Berlin Heidelberg
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Ratnatunga, C.P., Gorog, P., Kovacs, I.B., Ress, G.M. (1991). The Effect of Aprotinin on Platelet Function and Coagulation In Vitro. In: Friedel, N., Hetzer, R., Royston, D. (eds) Blood Use in Cardiac Surgery. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-06119-0_6
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DOI: https://doi.org/10.1007/978-3-662-06119-0_6
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-662-06121-3
Online ISBN: 978-3-662-06119-0
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