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Blood Damage and Activation in Cardiopulmonary Bypass

  • Ch. R. H. Wildevuur

Abstract

Three sources of damage and/or activation of blood in cardiopulmonary bypass (CPB) can be distinguished: mechanical damage, material-dependent, and materialindependent blood activation.

Keywords

Cardiopulmonary Bypass Blood Activation Blood Element Blood Damage Serum Bactericidical Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Adelman B, Michelson AD, Loscalzo J et al. (1985) Plasmin effect on platelet glycoprotein IBvon Willebrand factor interactions. Blood 65: 32–40PubMedGoogle Scholar
  2. 2.
    Aoyama T, Ino Y, Ozeki M, Oda M, Sato T, Kohiyama Y, Suzuki S, Fujita M (1984) Pharmacological studies of FUT-175, Nafamstat Mesilate I. Inhibition of protease activity in in vitro and in vivo experiments. Jap J Pharmacol 35: 203–227PubMedCrossRefGoogle Scholar
  3. 3.
    Boonstra PW, van Imhoff GW, Eijsman L, Kootstra GJ, Homan Heide JN, Karliczek GF, Wildevuur CRH (1985). Reduced platelet activation and improved hemostasis after controlled cardiotomy suction during clinical membrane oxygenator perfusions. J Thorac Cardiovasc Surg 89: 900–906PubMedGoogle Scholar
  4. 4.
    Ten Duis HJ, de Jong JCF, van Asseldonk AGM, Smit Sibinga CTh, Wildevuur ChRH (1978). Improved hemocompatibility in open heart surgery. Trans Am Soc Artif Intern Organs 24: 656–660PubMedGoogle Scholar
  5. 5.
    Dungen JJAM van den, Karliczek GF, Brenken U, Homan Heide JN, Wildevuur CRH (1982). Clinical study of blood trauma during perfusion with membrane and bubble oxygenators. J Thorac Cardiovasc Surg 83: 108–116PubMedGoogle Scholar
  6. 6.
    Editorial (1988). Can drugs reduce surgical blood loss? Lancet 11: 155–156Google Scholar
  7. 7.
    Horrow JC, Hlavacek J, Strong MD, Collier W, Brodsky I, Goldman SM, Goel IP (1990). Prophylactic transamic acid decreases bleeding after cardiac operations. J Thorac Cardiovasc Surg 99: 70–74PubMedGoogle Scholar
  8. 8.
    Jansen NJG, Oeveren W van, v d. Broek L, Oudemans-van Straten HM, Stoutenbeek CP, Chang Njoek Joen M, Roozendaal KJ, Eijsman L, Wildevuur CRH: Inhibition of the reperfusion phenomena in cardiopulmonary bypass by dexamethasone. J Thorac Cardiovasc Surg, in pressGoogle Scholar
  9. 9.
    De Jong JCF, ten Duis HJ, Smit Sibinga CTh, Wildevuur ChRH (1980). Hematologic aspects of cardiotomy suction in cardiac operations. J Thorac Cardiovasc Surg 79: 227–236PubMedGoogle Scholar
  10. 10.
    De Jong JCF, Smit Sibinga CTh, Wildevuur ChRH (1979). Platelet behaviour in extracorporeal circulation. Transfusion 19: 72–755.PubMedCrossRefGoogle Scholar
  11. 11.
    Kirklin JK, Chenoweth DE, Naftel DC, Blackstone EH, Kirklin JW, Bitran DD, Curd JG, Reves JG, Samuelson PN (1986). Effects of protamine administration after cardiopulmonary bypass on complement, blood elements, and the hemodynamic state. Ann Thorac Surg 41: 193–199PubMedCrossRefGoogle Scholar
  12. 12.
    Kirklin JK, Westaby S, Blackstone EH, Kirklin JW, Chenoweth DE, Pacifico AD (1983). Complement and the damaging effects of cardiopulmonary bypass. J Thorac Cardiovasc Surg 86: 845–857PubMedGoogle Scholar
  13. 13.
    Oeveren W van, Dankert J, Wildevuur ChRH (1987). Bubble oxygenation and cardiotomy suction impair the host defense during cardiopulmonary bypass: a study in dogs. Ann Thorac Surg 44: 523–528PubMedCrossRefGoogle Scholar
  14. 14.
    Oeveren W van, Eijsman L, Roozendaal KJ, Wildevuur CRH (1988). Platelet preservation by aprotinin during cardiopulmonary bypass. Lancet 11: 644CrossRefGoogle Scholar
  15. 15.
    Oeveren W van, Harder MP, Roozendaal KJ, Eijsman L, Wildevuur CRH (1990) Aprotinin protects against the initial effect of cardiopulmonary bypass. J Thorac Cardiovasc Surg 99: 788–797PubMedGoogle Scholar
  16. 16.
    Oeveren W van, Jansen NJG, Bidstrup BP, Royston D, Westaby S, Neuhof H, Wildevuur CRH (1987). Effects of aprotinin on hemostatic mechanisms in cardiopulmonary bypass. Ann Thorac Surg 44: 640–645PubMedCrossRefGoogle Scholar
  17. 17.
    Oeveren W van, Kazatchkine MD, Descamps-Latscha B, Maillet F, Fischer E, Carpentier A, Wildevuur CHR (1985). Deleterious effects of cardiopulmonary bypass: a prospective study of bubble versus membrane oxygenation. J Thorac Cardiovasc Surg 89: 888–889PubMedGoogle Scholar
  18. 18.
    Royston D, Bidstrup BP, Taylor KM, Sapsford RN (1987). Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet 1: 1289–1291CrossRefGoogle Scholar
  19. 19.
    de Smet AFA, Chang Njoek Joen M, Oeveren W van, Roozendaal KJ, Harder MP, Eijsman L, Wildevuur CRH: Increased anticoagulation during cardiopulmonary bypass by aprotinin. J Thorac Cardiovasc Surg, in pressGoogle Scholar
  20. 20.
    Teoh KH, Christakis GT, Weisel RD, Wong PY, Mee V, Ivanov J, Madonik MM, Levitt DS, Reilly PA, Rosenfeld JM, Glynn MFX (1988). Dipyridamole preserved platelets and reduced blood loss after cardiopulmonary bypass. J Thorac Cardiovasc Surg 96: 332–341PubMedGoogle Scholar
  21. 21.
    Tabuchi N, Oeveren W van, Eijsman L, Roozendaal KJ, Gu Yj, Wildevuur ChRH (1990). Preserved hemostasis during the combined use of aprotinin and aspirin in CABG operations. This Book.Google Scholar
  22. 22.
    Verbrugh HA, Dijk WCvan, Erne M Evan, Peters R, Peterson PK, Verhoef J(1979). Quantitation of the third component of human complement attached to the surface of opsonized bacteria: opsonin-defecient sera and phagocytosis-resistant strains. Infect Immun 26: 808–812PubMedGoogle Scholar
  23. 23.
    Wildevuur CHR, Oeveren Wvan (1987). The membrane artificial lung. Kolff Festschrift; Artificial Organs, Proc int symposium. pp 443–454Google Scholar
  24. 24.
    Woltjes J, de Jong JCF, ten Duis HJ, Wildevuur ChRH (1979). The priming of extracorporeal circuits: the effect on canine blood elements. Transfusion 19: 552–554PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Ch. R. H. Wildevuur
    • 1
    • 2
  1. 1.Department of Cardiopulmonary Surgery, Research DivisionUniversity Hospital GroningenThe Netherlands
  2. 2.Department of Cardiopulmonary Surgery, Research DivisionAcademisch Ziekenhuis GroningenGroningenThe Netherlands

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