Abstract
Antiplatelet medication is widely used in the treatment of cardiovascular disease today. The cheapest and least toxic of these is aspirin. It has been shown to reduce myocardial infarction and death in unstable angina [9, 11], vascular mortality after acute myocardial infarction [8] and, to a lesser extent, late after myocardial infarction. Improved results after coronary angioplasty [1] as well as better aorto-coronary vein graft patency [3, 7] have been demonstrated. With increasing frequency, patients admitted for coronary artery surgery have continued to take aspirin. It is now well established that aspirin is associated with an increased risk of bleeding and the need for blood-component therapy after extracorporeal circulation [6, 7, 10]. Highdose aprotinin (Trasylol, Bayer) is effective in reducing blood-transfusion needs in patients undergoing primary aorto-coronary bypass surgery, re-operations, and with infective endocarditis [2]. This paper reports our initial experience in a preliminary open study of the effect of aprotinin on bleeding in patients taking aspirin at the time of aorto-coronary bypass surgery.
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© 1991 Springer-Verlag Berlin Heidelberg
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Bidstrup, B.P. (1991). High-dose Aprotinin Reduces Bleeding in Patients Taking Aspirin at the Time of Aorto-Coronary Bypass Surgery. In: Friedel, N., Hetzer, R., Royston, D. (eds) Blood Use in Cardiac Surgery. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-06119-0_38
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DOI: https://doi.org/10.1007/978-3-662-06119-0_38
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-662-06121-3
Online ISBN: 978-3-662-06119-0
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