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Safety and Risk/Benefit Assessment of Aprotinin in Primary CABG

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Blood Use in Cardiac Surgery

Abstract

High-dose aprotinin administration in open-heart surgery has been proved to offer a major reduction in the need for donor blood [1, 2, 10]. We have performed several studies that all revealed a decrease of homologous blood requirement by 7 5%[4, 5].

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References

  1. Bidstrup BP, Royston D, Sapsford RN, Taylor KM (1989) Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol). J Thorac Cardiovasc Surg 97: 364–372

    PubMed  CAS  Google Scholar 

  2. Dietrich W, Barankay A, Dilthey G, Henze R, Niekau E, Sebening F, Richter JA (1989) Reduction of homologous blood requirement in cardiac surgery by intraoperative aprotinin application — Clinical experience in 152 cardiac surgical patients. Thorac Cardiovasc Surgeon 37: 92–98

    Article  CAS  Google Scholar 

  3. Edmunds LH, Addonizio VP (1987) Extracorporeal circulation. In: Colman RW, Hirsh J, Marder VJ, Salzman EW (eds) Hemostasis and thrombosis — Basic principles and clinical practice. JB Lippincott Co, Philadelphia, pp 901–912

    Google Scholar 

  4. Fraedrich G, Weber C, Bernard C, Hettwer A, Schlosser V (1989) Reduction of blood transfusion requirement in open heart surgery by administration of high doses of aprotinin — Preliminary results. Thorac Cardiovasc Surgeon 37: 89–91

    Article  CAS  Google Scholar 

  5. Fraedrich G, Engler H, Weber C, Schlosser V (1990) Effect and potential mechanism of high dose aprotinin regimen in open heart surgery — a prospective randomised double blind trial. In: Birnbaum D, Hoffmeister HE (eds) Blood saving in open heart surgery. Schattauer, Stuttgart—New York, in press

    Google Scholar 

  6. Freeman JG, Turner GA, Venables CW, Latner AL (1983) Serial use of aprotinin and incidence of allergic reactions. Curr Med Res Opin 8: 559–561

    Article  PubMed  CAS  Google Scholar 

  7. Frith H, Wunderer G, Jochum M (1983) Biochemie und Anwendung des Kallikreininhibitors Aprotinin aus Rinderorganen. Arzneim Forsch Drug Res 33: 479–494

    Google Scholar 

  8. Hofmann W, Guder WG (1989) A diagnostic programme for quantitative analysis of proteinuria. J Clin Chem Clin Biochem 27: in press

    Google Scholar 

  9. Sunamori M, Innami R, Amano J, Suzuki A, Harrison CE (1988) Role of protease inhibition in myocardial preservation in prolonged hypothermic cardioplegia followed by reperfusion. J Thorac Cardiovasc Surg 96: 414–320

    Google Scholar 

  10. van Oeveren W, Jansen NJ, Bidstrup BP, Royston D, Westaby S, Neuhof H (1987) Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass. Ann Thorac Surg 44: 640–645

    Article  PubMed  CAS  Google Scholar 

  11. Weiss ME, Adkinson NF, Hirshman CA (1989) Evaluation of allergic drug reactions in the perioperative period. Anesthesiology 71: 483–486

    Article  PubMed  CAS  Google Scholar 

  12. Yanagihara Y, Shida T (1985) Immunological studies on patients who received aprotinin therapy. Jpn J Allergol 34: 899–904

    CAS  Google Scholar 

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© 1991 Springer-Verlag Berlin Heidelberg

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Fraedrich, G. et al. (1991). Safety and Risk/Benefit Assessment of Aprotinin in Primary CABG. In: Friedel, N., Hetzer, R., Royston, D. (eds) Blood Use in Cardiac Surgery. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-06119-0_36

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  • DOI: https://doi.org/10.1007/978-3-662-06119-0_36

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-06121-3

  • Online ISBN: 978-3-662-06119-0

  • eBook Packages: Springer Book Archive

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