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Circadian Organization in Fish and Amphibians

  • G. M. Cahill

Abstract

Circadian systems in fish and amphibians share several characteristics with other non-mammalian vertebrates. The most salient of these characteristics at the physiological level is the presence in multiple tissues of independently photosensitive and self-sustaining circadian oscillators. The circadian oscillators that regulate melatonin synthesis in the pineal and retina have been the most extensively investigated. In particular, studies of teleost pineals and of the retina of Xenopus laevis have contributed to our understanding of the cellular and molecular bases of rhythm generation, entrainment and output pathways in these organs. However, our understanding of how these and other oscillatory structures interact to drive rhythmicity in intact fish and amphibians has lagged behind progress in other vertebrates, primarily because convenient and reliable measures of behavioral rhythmicity were lacking. Recent technical advances have made it possible to record robust swimming activity rhythms from larval zebrafish. These methods may also be applicable to measurement of behavioral rhythms in other fish and amphibians. Recent studies of the zebrafish and Xenopus homologs of mammalian clock-related genes indicates that molecular clock mechanisms in fish and amphibians are similar, but not identical to those in other vertebrates. In particular, these studies have revealed new complexities in molecular mechanisms of vertebrate circadian rhythmicity, and they have also contributed to our understanding of system organization in these animals.

Keywords

Circadian Clock Circadian System Circadian Oscillator Melatonin Secretion Larval Zebrafish 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • G. M. Cahill
    • 1
  1. 1.Department of Biology and BiochemistryUniversity of HoustonHoustonUSA

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