Peroxisomes

  • S. Boisnard
  • G. Ruprich-Robert
  • M. Picard
  • V. Berteaux-Lecellier
Chapter
Part of the The Mycota book series (MYCOTA, volume 3)

Abstract

Microbodies were first observed by Rhodin (1954). These single-membrane organelles, whose size varies between 0.1 and lμm, are present in nearly all eukaryotic cells. Since their isolation by de Duve and Baudhuin (1966), they have been termed “peroxisomes” due to the close association in their matrix of both H2O2-generating and -degrading enzymes (Sect. II). While dispensable in yeasts, their importance in humans was demonstrated by the discovery of the first peroxisomal disease (Goldfisher et al. 1973), which initiated the beginning of serious studies of these organelles. Peroxisomal diseases are due to the absence of either one or several metabolic functions of peroxisomes (reviewed by Lazarow 1995; Wanders et al. 1995; Gould and Valle 2000; Moser 2000). The multiple metabolic deficiencies are due to impairment in peroxisome biogenesis and result in peroxisome biogenesis disorders, the most severe of which is Zellweger syndrome.

Keywords

Peroxi Respiration Penicillin Oligomerization Neurol 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • S. Boisnard
  • G. Ruprich-Robert
  • M. Picard
  • V. Berteaux-Lecellier
    • 1
  1. 1.Institut de Génétique et MicrobiologieUMR-CNRS 8621Orsay CedexFrance

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