Zusammenfassung
Wegen ihrer vielfältigen und unerlässlichen Funktionen wäre ohne Lipide Leben nicht möglich. Lipide bilden die Grundstruktur sämtlicher zellulären Membranen und ermöglichen auf diese Weise erst die Existenz von Zellen, deren Inneres gegen die Außenwelt abgeschirmt ist. Über diese entscheidende Funktion hinaus spielen Lipide in Form der Triacylglycerine eine große Rolle als intrazelluläre Energiespeicher. Sie kommen in nahezu allen Zellen vor, werden jedoch in großen Mengen in einem spezifischen Gewebe, dem Fettgewebe gespeichert.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Cases S et al. (1998) Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci Usa 95: 13 018–13 023
Coleman RA, Lewin TM, Muoio DM (2000) Physiological and nutritional regulation of enzymes of triacylglycerol synthesis. Annu Rev Nutr 20: 77–103
Flower DR (1996) The lipocalin protein family: structure and function. Biochem J 318: 1–14
Gibbons FG, Islam K, Pease RJ (2000) Mobilisation of triacylglycerol stores. Biochim Biophys Acta 1483: 37–57
Goldberg I, Merkel M (2001) Lipoprotein Lipase: Physiology, Biochemistry and Molecular Biology. Front Biosci 6: D388–405
Goodwin DC, Landino LM, Marnett LJ (1999) Effects of nitric oxide and nitric oxide-derived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis. Faseb J 13: 1121–1136
Haemmerle G et al.: Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle and testis. Jbc Papers in Press. Published on November 20, 2001 as Manuscript Mil035 5200
Jump DB, Clarke SD (1999) Regulation of gene ex- pression by dietary fat. Annu Rev Nutr 19: 63–90
Kim KH (1997) Regulation of mammalian acetyl-coenzyme A carboxylase. Annu Rev Nutr 17: 77–99
Narumiya S, Sugimoto Y, Ushikubi F (1999) Prostanoid Receptors: Structures, Properties, and Functions. Physiol Rev 79: 1193–1226
Osterlund T (2001) Structure-function relationships of hormone sensitive lipase. Eur J Biochem 268: 1899–1907
Saltiel AR (2001) Another hormone-sensitive triglyceride lipase in fat cells? Proc Natl Acad Sci (Usa) 97: 535–537
Smith S (1994) The animal fatty acid synthase: one gene, one polypeptide, seven enzymes.
Faseb J 8: 1248–1259
Smith WL, Dewitt DL, Garavito RM (2000) Cyclooxygeases: strucutural, cellular and molecular biology. Annu Rev Biochem 69: 145–182
Stahl A, Gimeno RE, Tartaglia LA, Lodish HF (2001) Fatty acid transport proteins: a current view of a growing family. Trends in Endocrinology and Metabolism 12: 266–273
SuL HS, Wang D (1998) Nutritional and hormonal regulation of enzymes in fat synthesis: Studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu Rev Nutr 18: 331–51
Zammit VA (1999) The malonyl-CoA-long-chain acylCoA axis in the maintenance of mammalian cell function. Biochem J 343: 505–515
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Löffler, G. (2003). Stoffwechsel von Triacylglycerinen und Fettsäuren. In: Löffler, G., Petrides, P.E. (eds) Biochemie und Pathobiochemie. Springer-Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06058-2_14
Download citation
DOI: https://doi.org/10.1007/978-3-662-06058-2_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-06059-9
Online ISBN: 978-3-662-06058-2
eBook Packages: Springer Book Archive