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Uptake of Protein Toxins Acting Inside Cells

  • Chapter
Bacterial Protein Toxins

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 145))

Abstract

Bacterial protein toxins act either at the level of the cell surface or on targets in the cytosol. Superantigens and toxins containing lytic activity exert their action at the level of the cell surface and will not be discussed here. However, an increasing number of bacterial protein toxins are being demonstrated to have intracellular sites of action. This implies that the toxins must be able to cross cellular membranes. Most toxins do this by crossing membranes of intracellular organelles rather than penetrating the plasma membrane.

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Authors
  1. S. Olsnes
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  2. J. Wesche
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  3. P. Ø. Falnes
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Editors and Affiliations

  1. Institut für Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 5, 79104, Freiburg i. Br., Germany

    Klaus Aktories  & Ingo Just  & 

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Olsnes, S., Wesche, J., Falnes, P.Ø. (2000). Uptake of Protein Toxins Acting Inside Cells. In: Aktories, K., Just, I. (eds) Bacterial Protein Toxins. Handbook of Experimental Pharmacology, vol 145. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05971-5_1

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  • DOI: https://doi.org/10.1007/978-3-662-05971-5_1

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