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Bacillus anthracis Cell Envelope Components

  • Chapter
Anthrax

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 271))

Abstract

Bacillus anthracis is a Gram-positive bacterium harboring a complex parietal architecture. The cytoplasmic membrane is surrounded by a thick peptidoglycan of the A1γ type. Only one associated polymer, a polysaccharide composed of galactose, N-acetylglucosamine, and N-acetylmannosamine, is covalently linked to the peptidoglycan. Outside the cell wall is an S-layer. Two proteins can each compose the S-layer. They are noncovalently anchored to the cell wall polysaccharide by their SLH N-terminal domain. The poly-γ-d-glutamate capsule, which covers the S-layer, has an antiphagocytic role and its synthesis is dependent on environmental factors mimicking the mammalian host, such as bicarbonate and a temperature of 37°C.

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  1. S. Mesnage

    Present address: Laboratoire de Recherche Moléculaire sur les Antibiotiques (L.R.M.A.), 15 rue de l’Ecole de Médecine, 75270, Paris cédex 05, France

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  1. Toxines et Pathogénie Bactériennes (URA 2172, CNRS), Institut Pasteur, 28 rue du Dr Roux, 75724, Paris cédex 15, France

    A. Fouet

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  1. Department of Microbiology and Molecular Genetics, University of Texas — Houston Medical School, 6431 Fannin Street, JFB 1.765, 77030, Houston, TX, USA

    Theresa M. Koehler Ph.D.

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Fouet, A., Mesnage, S. (2002). Bacillus anthracis Cell Envelope Components. In: Koehler, T.M. (eds) Anthrax. Current Topics in Microbiology and Immunology, vol 271. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05767-4_5

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  • DOI: https://doi.org/10.1007/978-3-662-05767-4_5

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