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Physiologie der Hodenfunktion

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Andrologie

Zusammenfassung

Dieses Kapitel stellt die physiologischen Grundlagen für das Verständnis der dualen Funktion der männlichen Keimdrüse dar. Die nachfolgend beschriebenen Sachverhalte gelten überwiegend für die Situation beim Menschen. Tierexperimentelle Befunde wurden in den Fällen herangezogen, in denen Humandaten nicht vorliegen oder aus ethischen Überlegungen nicht erhoben werden können, und um Konzepte und Theorien verständlich zu machen. Die Beschreibung der Organisation der Hoden und der physiologischen Grundlagen der Keimzellreifung orientiert sich an den Gegebenheiten im Humantestis und liefert die Grundlage für das Verständnis der endokrinen und der lokalen Regulation der Hodenfunktion. Daran schließt sich die Beschreibung des hypothalamisch-hypophysären-testikulären Regelkreises an, der die „Oberhoheit“ bei der physiologischen Regulation der Hodenfunktion besitzt und ein Regelsystem im klassischen endokrinen Sinne darstellt. Lokale Regulationsmechanismen spielen eine bedeutende Rolle beim „fine-tuning“ der Keimzellreifung. Den Abschluss des Kapitels bildet eine ausführliche Darstellung der Synthese und der biologischen Wirkungen der Androgene im Organismus.

Die Hoden (Testes) erfullen 2 wesentliche Funktionen die Produktien und Bereitstellung der mannlichen Gameten und die Synthese und Sekretion der mannfichen Geschie Chtshormone.

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Authors
  1. G. F. Weinbauer
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  2. J. Gromoll
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  3. M. Simoni
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  4. E. Nieschlag
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Editors and Affiliations

  1. Institut für Reproduktionsmedizin, Westfälischen Wilhelms-Universität, Domagkstr. 11, D-48129, Münster, Deutschland

    Eberhard Nieschlag FRCP

  2. Zentrum für Frauenheilkunde, Westfälischen Wilhelms-Universität, Albert-Schweitzer-Str. 33, D-48129, Münster, Deutschland

    Hermann M. Behre

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Weinbauer, G.F., Gromoll, J., Simoni, M., Nieschlag, E. (2000). Physiologie der Hodenfunktion. In: Nieschlag, E., Behre, H.M. (eds) Andrologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05739-1_3

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  • DOI: https://doi.org/10.1007/978-3-662-05739-1_3

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