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Zusammenfassung

Die altersabhängige Makuladegeneration (AMD) ist eine progrediente Erkrankung des zentralen Netzhaut-/Pigmentepithel-/Aderhaut-Komplexes. Eine AMD liegt vor, wenn eine oder mehrere der nachgenannten Veränderungen im Bereich der Makula vorliegen:

  • weiche Drusen: gelbliche Ablagerungen, ≥63 µm zwischen dem retinalen Pigmentepithel und der Bruch-Membran,

  • Hyper- oder Hypopigmentationen des retinalen Pigmentepithels,

  • geographische Atrophie des retinalen Pigmentepithels: scharf begrenzte Gebiete einer Atrophie des retinalen Pigmentepithels und der Choriokapillaris,

  • neovaskuläre Makuladegeneration: choroidale Neovaskularisation, seröse oder hämorrhagische Abhebung des retinalen Pigmentepithels oder spätere Vernarbung der Makula in Form einer disziformen Narbe.

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Literatur

  • Age-Related Eye Disease Study Research Group (2000) Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: age-related eye disease study report number 3. Ophthalmology 107: 2224–2232

    Google Scholar 

  • Ajani UA et al. (1999) A prospective study of alcohol consumption and the risk of age-related macular degeneration. Ann Epidemiol 9: 172–177

    Article  PubMed  CAS  Google Scholar 

  • Allikmets R (2000) Further evidence for an association of ABCR alleles with age-related macular degeneration.The International ABCR Screening Consortium. Am J Hum Genet 67: 487–491

    Article  PubMed  CAS  Google Scholar 

  • Allikmets R et al. (1997) A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet 15: 236–246

    Article  PubMed  CAS  Google Scholar 

  • Anderson DH et al. (2001) Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation. Am J Ophthalmol 131: 767–781

    CAS  Google Scholar 

  • AREDS Report no.8 (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. Arch Ophthalmol 119: 1417–1436

    Google Scholar 

  • Beatty Set (2000) The role of oxidative stress in the pathogenesis of age-related macular degeneration. Sury Ophthalmol 45: 115–134

    Article  CAS  Google Scholar 

  • Bird AC et al. (1995) An international classification and grading system for age-related maculopathy and age-related macular degeneration.The International ARM Epidemiological Study Group. Sury Ophthalmol 39: 367–374

    Article  CAS  Google Scholar 

  • Blumenkranz MS et aí. (1986) Risk factors in age-related maculopathy complicated by choroidal neovascularization. Ophthalmology 93: 552–558

    PubMed  CAS  Google Scholar 

  • Bressler NM et al. (1989) The grading and prevalence of macular degeneration in Chesapeake Bay watermen. Arch Ophthalmol 107: 847–852

    Article  PubMed  CAS  Google Scholar 

  • Bressler NM et aí. (1995) Five-year incidence and disappearance of drusen and retinal pigment epithelial abnormalities.Waterman study. Arch Ophthalmol 113: 301–308

    Article  PubMed  CAS  Google Scholar 

  • Cai Jet (2000) Oxidative damage and protection of the RPE. Prog Retin Eye Res 19: 205–221

    Article  PubMed  CAS  Google Scholar 

  • Chang B et al. (1995) Choroidal neovascularization in second eyes of patients with unilateral exudative age-related macular degeneration. Ophthalmology 102: 1380–1386

    PubMed  CAS  Google Scholar 

  • Cho E et al. (2000) Prospective study of alcohol consumption and the risk of age-related macular degeneration. Arch Ophthalmol 118: 681–688

    Article  PubMed  CAS  Google Scholar 

  • Cho E et al. (2001) Prospective study of zinc intake and the risk of age-related macular degeneration. Ann Epidemiol 11: 328–336

    Article  PubMed  CAS  Google Scholar 

  • Christen WG et al. (1996) A prospective study of cigarette smoking and risk of age-related macular degeneration in men.JAMA 276: 1147–1151

    CAS  Google Scholar 

  • Christen WG et al. (1999) Prospective cohort study of antioxidant vitamin supplement use and the risk of age-related maculopathy. Am J Epidemiol 149: 476–484

    Article  PubMed  CAS  Google Scholar 

  • Christen WG et al. (2001) Age-related maculopathy in a randomized trial of low-dose aspirin among US physicians. Arch Ophthalmol 119: 1143–1149

    PubMed  CAS  Google Scholar 

  • Cruickshanks KJ, Klein R, Klein BE (1993) Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch Ophthalmol 111: 514–518

    Google Scholar 

  • Cruickshanks KJ et al. (1997) The prevalence of age-related maculopathy by geographic region and ethnicity. The Colorado-Wisconsin Study of Age-Related Maculopathy. Arch Ophthalmol 115: 242–250

    Article  PubMed  CAS  Google Scholar 

  • Cruickshanks KJ et al. (2001) Sunlight and the 5-year incidence of early age-related maculopathy: the beaver dam eye study. Arch Ophthalmol 119: 246–250

    PubMed  CAS  Google Scholar 

  • Curcio CA et al. (2001) Accumulation of cholesterol with age in human Bruch’s membrane. Invest Ophthalmol Vis Sci 42: 265–274

    PubMed  CAS  Google Scholar 

  • Delaney WV, Oates RP (1982) Senile macular degeneration: a preliminary study. Ann Ophthalmol 14: 21–24

    PubMed  Google Scholar 

  • De la Paz MA et al. (1997a) Exclusion of TIMP3 as a candidate locus in age-related macular degeneration. Invest Ophthalmol Vis Sci 38: 1060–1065

    Google Scholar 

  • De la Paz MA et al. (1997b) Phenotypic heterogeneity in families with age-related macular degeneration. Am J Ophthalmol 124: 331–343

    PubMed  Google Scholar 

  • Delcourt C et al. (1998) Smoking and age-related macular degeneration.The POLA Study. Pathologies oculaires liees a l’age. Arch Ophthalmol 116: 1031–1035

    PubMed  CAS  Google Scholar 

  • Delcourt C et al. (1999a) Associations of antioxidant enzymes with cataract and age-related macular degeneration.The POLA Study. Pathologies oculaires liees a l’age. Ophthalmology 106: 215–222

    Article  PubMed  CAS  Google Scholar 

  • Delcourt C et al. (1999b) Age-related macular degeneration and antioxidant status in the POLA study. POLA Study Group. Pathologies oculaires liees a l’age. Arch Ophthalmol 117: 1384–1390

    PubMed  CAS  Google Scholar 

  • Diaz MN et al. (1997) Antioxidants and atherosclerotic heart disease. N Engl J Med 337: 408–416

    Article  PubMed  CAS  Google Scholar 

  • Evans JR (2001) Risk factors for age-related macular degeneration. Prog Retin Eye Res 20: 227–2253

    Article  PubMed  CAS  Google Scholar 

  • Eye Disease Case-Control Study Group (1993) Antioxidant status and neovascular age-related macular degeneration. Arch Ophthalmol 111: 104–109

    Google Scholar 

  • Foran S, Mitchell P, Wang Jl (2002) Five-year change in visual acuity and incidence of visual impairment.Ophthalmology 110: 41–50

    Google Scholar 

  • Friedman DS et al. (1999) Racial differences in the prevalence of age-related macular degeneration: the Baltimore Eye Survey. Ophthalmology 106: 1049–1055

    Article  PubMed  CAS  Google Scholar 

  • Friedman E (1970) Choroidal blood flow. Pressure-flow relationships. Arch Ophthalmol 83: 95–99

    Article  PubMed  CAS  Google Scholar 

  • Friedman E (2000) The role of the atherosclerotic process in the pathogenesis of age-related macular degeneration. Am J Ophthalmol 130: 658–663

    Article  PubMed  CAS  Google Scholar 

  • Gass JD (1967) Pathogenesis of disciform detachment of the neuroepithel ium. Am 1 Ophthalmol 63 [suppl]: 1–139

    Google Scholar 

  • Gass JD (1973) Drusen and disciform macular detachment and degeneration. Arch Ophthalmol 90: 206–217

    Article  PubMed  CAS  Google Scholar 

  • Gibson JM, Rosenthal AR, Lavery J (1985) A study of the prevalence of eye disease in the elderly in an English community.Trans Ophthalmol Soc U K 104: 196–203

    Google Scholar 

  • Goldberg L (1988) Factors associated with age-related macular degeneration. An analysis of data from the first National Health and Nutrition Examination Survey. Am J Epidemiol 128: 700–710

    Google Scholar 

  • Gorin MB etal. (2001) Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within 1q31 and 17q25 regions. Am J Hum Genet 46, abstr 2117

    Google Scholar 

  • Gregor Z, Bird AC,Chisholm ICH (1977) Senile disciform macular degeneration in the second eye. Br J Ophthalmol 61: 141–147

    Article  CAS  Google Scholar 

  • Guymer RH et al. (2001) Variation of codons 1961 and 2177 of the Stargardt disease gene is not associated with age-related macular degeneration. Arch Ophthalmol 119: 745–751

    PubMed  CAS  Google Scholar 

  • Hammond Cl (2001) Genetic influence on early age-related macular degeneration: a population-based twin study. Invest Ophthalmol Vis Sci 42:5310, abstr 1670

    Google Scholar 

  • Heiba IM et al. (1994) Sibling correlations and segregation analysis of age-related maculopathy:the Beaver Dam Eye Study. Genet Epidemiol 11: 51–67

    Article  PubMed  CAS  Google Scholar 

  • Hirvela H et al. (1996) Risk factors of age-related maculopathy in a population 70 years of age or older. Ophthalmology 103: 871–877

    PubMed  CAS  Google Scholar 

  • Holz FG et al. (1994a) Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors. Ophthalmology 101: 1522–1528

    PubMed  CAS  Google Scholar 

  • Holz FG et al. (1994b) Decreasing stromal iris pigmentation as a risk factor for age-related macular degeneration. Am J Ophthalmol 117: 19–23

    PubMed  CAS  Google Scholar 

  • Hyman LG et al. (1983) Senile macular degeneration: a case-control study. Am J Epidemiol 118: 213–227

    PubMed  CAS  Google Scholar 

  • Hyman L et al. (2000) Hypertension, cardiovascular disease, and age-related macular degeneration. Age-Related Macular Degeneration Risk Factors Study Group. Arch Ophthalmol 118: 351–358

    PubMed  CAS  Google Scholar 

  • Ikeda T et al. (2001) Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration. Am 1 Ophthalmol 132: 191–195

    Article  CAS  Google Scholar 

  • Jonasson F,Thordarson K (1987) Prevalence of ocular disease and blindness in a rural area in the eastern region of Iceland during 1980 through 1984. Acta Ophthalmol 182 [suppl]: 40–43

    Google Scholar 

  • Kahn HA et aí. (1977) The Framingham Eye Study.I.Outline and major prevalence findings. Am 1 Epidemiol 106: 17–32

    CAS  Google Scholar 

  • Kimura K et al. (2000) Genetic association of manganese superoxide dismutase with exudative age-related macular degeneration. Am J Ophthalmol 130: 769–773

    Article  PubMed  CAS  Google Scholar 

  • Klaver CC et al. (1998a) Genetic risk of age-related maculopathy. Population-based familial aggregation study. Arch Ophthalmol 116: 1646–1651

    Article  PubMed  CAS  Google Scholar 

  • Klaver CC et al. (1998b) Genetic association of apolipoprotein E with age-related macular degeneration. Am J Hum Genet 63: 200–206

    Article  CAS  Google Scholar 

  • Klaver CC et al. (1999) Is age-related maculopathy associated with Alzheimer’s disease?The Rotterdam Study.Am J Epidemiol 150: 963–968

    CAS  Google Scholar 

  • Klaver CC et al. (2001) Incidence and progression rates of age-related maculopathy: the Rotterdam Study. Invest Ophthalmol Vis Sci 42: 2237–2241

    PubMed  CAS  Google Scholar 

  • Klein BE, Klein R (1982) Cataracts and macular degeneration in older Americans. Arch Ophthalmol 100: 571–3

    Article  PubMed  CAS  Google Scholar 

  • Klein BE et al. (1994) Are sex hormones associated with age-related maculopathy in women? The Beaver Dam Eye Study.Trans Am Ophthalmol Soc 92: 289–295

    CAS  Google Scholar 

  • Klein BE, Klein R, Lee KE (2000) Reproductive exposures, incident age-related cataracts, and age-related maculopathy in women: the beaver dam eye study. Am J Ophthalmol 130: 322–326

    Article  PubMed  CAS  Google Scholar 

  • Klein BE et al. (2001) Risk of incident age-related eye diseases in people with an affected sibling:The Beaver Dam Eye Study.Am J Epidemiol 154: 207–211

    CAS  Google Scholar 

  • Klein ML, Mauldin WM,StoumbosVD (1994) Heredity and age-related macular degeneration. Observations in monozygotic twins. Arch Ophthalmol 112: 932–937

    Google Scholar 

  • Klein ML et al. (1998) Age-related macular degeneration.Clinical features in a large family and linkage to chromosome 1g. Arch Ophthalmol 116: 1082–1088

    PubMed  CAS  Google Scholar 

  • Klein R et al. (1991) The Wisconsin age-related maculopathy grading system. Ophthalmology 98: 1128–1134

    PubMed  CAS  Google Scholar 

  • Klein R, Klein BE, Moss SE (1992a) Diabetes, hyperglycemia, and age-related maculopathy.The Beaver Dam Eye Study. Ophthalmology 99: 1527–1534

    PubMed  CAS  Google Scholar 

  • Klein R, Klein BE, Linton KL (1992b) Prevalence of age-related maculopathy.The Beaver Dam Eye Study.Ophthalmology 99: 933–943

    CAS  Google Scholar 

  • Klein R, Klein BE, FrankeT (1993) The relationship of cardiovascular disease and its risk factors to age-related maculopathy.The Beaver Dam Eye Study. Ophthalmology 100: 406–414

    CAS  Google Scholar 

  • Klein R et al. (1994) Is age-related maculopathy associated with cataracts? Arch Ophthalmol 112: 191–196

    Article  PubMed  CAS  Google Scholar 

  • Klein R et al. (1995a) The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci 36: 182–191

    PubMed  CAS  Google Scholar 

  • Klein R, Rowland ML, Harris MI (1995b) Racial/ethnic differences in age-related maculopathy. Third National Health and Nutrition Examination Survey. Ophthalmology 102: 371–381

    Google Scholar 

  • Klein R et al. (1997a) The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 104: 7–21

    PubMed  CAS  Google Scholar 

  • Klein R, Klein BE, Jensen SC (1997b) The relation of cardiovascular disease and its risk factors to the 5-year incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 104: 1804–1812

    PubMed  CAS  Google Scholar 

  • Klein R et al. (1998a) The relationship of ocular factors to the incidence and progression of age-related maculopathy. Arch Ophthalmol 116: 506–513

    PubMed  CAS  Google Scholar 

  • Klein R, Klein BE, Moss SE (1998b) Relation of smoking to the incidence of age-related maculopathy. The Beaver Dam Eye Study. Am J Epidemiol 147: 103–110

    Google Scholar 

  • Klein R et al. (1998c) Is age-related maculopathy related to hearing loss? Arch Ophthalmol 116: 360–365

    PubMed  CAS  Google Scholar 

  • Klein R et al. (1999a) Age-related maculopathy in a multiracial United States population: the National Health and Nutrition Examination Survey Ill. Ophthalmology 106: 1056–1065

    Article  PubMed  CAS  Google Scholar 

  • Klein R et al. (1999b) Prevalence of age-related maculopathy in the atherosclerosis risk in communities study. Arch Ophthalmol 117: 1203–1210

    Article  PubMed  CAS  Google Scholar 

  • Klein R et al. (2001) Medication use and the 5-year incidence of early age-related maculopathy: The Beaver Dam Eye Study. Arch Ophthalmol 119: 1354–1359

    Article  PubMed  CAS  Google Scholar 

  • Kohner EM, Patel V, Rassam SM (1995) Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy. Diabetes 44: 603–607

    Article  PubMed  CAS  Google Scholar 

  • Kornzweig AL (1977) Changes in the choriocapillaris associated with senile macular degeneration. Ann Ophthalmol 9: 759–762

    Google Scholar 

  • Leibowitz HM et al. (1980) The Framingham Eye Study monograph: an ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973–1975. Sury Ophthalmol 24 [suppl]: 335–610

    Article  CAS  Google Scholar 

  • Liu IY, White L, LaCroix AZ (1989) The association of age-related macular degeneration and lens opacities in the aged. Am 1 Public Health 79: 765–769

    Article  CAS  Google Scholar 

  • Lotery AJ et al. (2000) Allelic variation in the VMD2 gene in best disease and age-related macular degeneration. Invest Ophthalmol Vis Sci 41: 1291–1296

    PubMed  CAS  Google Scholar 

  • Macular Photocoagulation Study Group (1993) Five-year follow-up of fellow eyes of patients with age-related macular degeneration and unilateral extrafoveal choroidal neovascularization. Arch Ophthalmol 111: 1189–1199

    Article  Google Scholar 

  • Macular Photocoagulation Study Group (1997) Risk factors for choroidal neovascularization in the second eye of patients with juxtafoveal or subfoveal choroidal neovascularization secondary to age-related macular degeneration. Arch Ophthalmol 115: 741–747

    Article  Google Scholar 

  • Maltzman BA, Mulvihill MN,Greenbaum A (1979) Senile macular degeneration and risk factors: a case-control study. Ann Ophthalmol 11: 1197–1201

    CAS  Google Scholar 

  • Mares-Perlman JA et al. (1995) Dietary fat and age-related maculopathy. Arch Ophthalmol 113: 743–748

    Article  PubMed  CAS  Google Scholar 

  • Mares-Perlman JA et al. (1996) Association of zinc and antioxidant nutrients with age-related maculopathy. Arch Ophthalmol 114: 991–997

    Article  PubMed  CAS  Google Scholar 

  • Mares-Perlman JA et al. (2001) Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Am J Epidemiol 153: 424–432

    Article  PubMed  CAS  Google Scholar 

  • Martinez GS et al. (1982) Prevalence of ocular disease in a population study of subjects 65 years old and older. Am J Ophthalmol 94: 181–189

    PubMed  CAS  Google Scholar 

  • Mata NL et al. (2001) Delayed dark-adaptation and lipofuscin accumulation in abcr+/-mice: implications for involvement of ABCR in age-related macular degeneration. Invest Ophthalmol Vis Sci 42: 1685–1690

    PubMed  CAS  Google Scholar 

  • McCarty CA et al. (2001) Risk factors for age-related maculopathy: the Visual Impairment Project. Arch Ophthalmol 119: 1455–1462

    Article  PubMed  CAS  Google Scholar 

  • Meyers SM, Greene T, Gutman FA (1995) A twin study of age-related macular degeneration. Am J Ophthalmol 120: 757–766

    PubMed  CAS  Google Scholar 

  • Mitchell P,Smith W, Wang JJ (1998) Iris color, skin sun sensitivity, and age-related maculopathy.The Blue Mountains Eye Study. Ophthalmology 105: 1359–1363

    Article  Google Scholar 

  • Mitchell RA (1993) Prevalence of age related maculardegeneration in persons aged 50 years and over resident in Australia.) Epidemiol Community Health 47: 42–45

    CAS  Google Scholar 

  • Montalescot G et al. (1998) Fibrinogen as a risk factor for coro- nary heart disease. Eur Heart J 19 [suppl H]: H11–17

    PubMed  CAS  Google Scholar 

  • Mullins RF et aí. (2000) Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. Faseb J 14: 835–846

    PubMed  CAS  Google Scholar 

  • Newsome DA et al. (1988) Oral zinc in macular degeneration. Arch Ophthalmol 106: 192–198

    Article  PubMed  CAS  Google Scholar 

  • Paetkau ME et al. (1978) Senile disciform macular degeneration and smoking.Can J Ophthalmol 13: 67–71

    CAS  Google Scholar 

  • Pagliarini S et al. (1997) Age-related macular disease in rural southern Italy. Arch Ophthalmol 115: 616–622

    Article  PubMed  CAS  Google Scholar 

  • Pang CP (2000)The apolipoprotein E epsilon4 allele is unlikely to be a major risk factor of age-related macular degeneration in Chinese. Ophthalmologica 214:289–291

    Google Scholar 

  • Piquet Bet (1993) Age-related Bruch’s membrane change: a clinical study of the relative role of heredity and environment. Br J Ophthalmol 77: 400–403

    Article  Google Scholar 

  • Pollack A et aí. (1996) Age-related macular degeneration after extracapsular cataract extraction with intraocular lens implantation. Ophthalmology 103: 1546–1554

    PubMed  CAS  Google Scholar 

  • Pryor WA et al. (1983) The radicals in cigarette tar:their nature and suggested physiological implications. Science 220: 425–427

    Article  PubMed  CAS  Google Scholar 

  • Ritter LL et al. (1995) Alcohol use and age-related maculopathy in the Beaver Dam Eye Study. Am J Ophthalmol 120: 190–196

    PubMed  CAS  Google Scholar 

  • Rosenthal FS et al. (1991) Ocular and facial skin exposure to ultraviolet radiation in sunlight:a personal exposure model with application to a worker population. Health Phys 61: 77–86

    Article  PubMed  CAS  Google Scholar 

  • Rothman KJ, Greenland S (1998) Modern epidemiology, 2nd ed. Lippincott-Raven, Philadelphia, xiii, p 737

    Google Scholar 

  • Roy M, Kaiser-Kupfer M (1990) Second eye involvement in age-related macular degeneration:a four-year prospective study. Eye 4: 813–818

    Article  PubMed  Google Scholar 

  • Ryan SJ, Mitt! RN, Maumenee AE (1980)The disciform response: an historical perspective. Albrecht Von Graefes Arch Klin Exp Ophthalmol 215: 1–20

    Google Scholar 

  • Sandberg MA et al. (1993) Hyperopia and neovascularization in age-related macular degeneration. Ophthalmology 100: 1009–1013

    PubMed  CAS  Google Scholar 

  • Sandberg MA et al. (1998) High-risk characteristics of fellow eyes of patients with unilateral neovascular age-related macular degeneration. Ophthalmology 105: 441–447

    Article  PubMed  CAS  Google Scholar 

  • Sanders TA et al. (1993) Essential fatty acids, plasma cholesterol, and fat-soluble vitamins in subjects with age-related maculopathy and matched control subjects. Am J Clin Nutr 57: 428–433

    PubMed  CAS  Google Scholar 

  • Sarraf D et al. (1999) Long-term drusen study. Retina 19: 513–519

    Article  PubMed  CAS  Google Scholar 

  • Schachat AP et al. (1995) Features of age-related macular degeneration in a black population.The Barbados Eye Study Group. Arch Ophthalmol 113: 728–735

    Article  PubMed  CAS  Google Scholar 

  • Schaumberg DA et aí. (2001) Body mass index and the incidence of visually significant age-related maculopathy in men. Arch Ophthalmol 119: 1259–1265

    Article  PubMed  CAS  Google Scholar 

  • Schectman G, Byrd JC, Gruchow HW (1989) The influence of smoking on vitamin C status in adults.Am J Public Health 79: 158–162

    Article  CAS  Google Scholar 

  • Schmidt S et al. (2000) Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender. Mol Vis 6: 287–293

    CAS  Google Scholar 

  • Seddon JM et al. (1994) Dietary carotenoids,vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group.JAMA 272: 1413–1420

    CAS  Google Scholar 

  • Seddon JM et al. (1996) A prospective study of cigarette smoking and age-related macular degeneration in women. Jama 276: 1141–1146

    Article  PubMed  CAS  Google Scholar 

  • Seddon JM,Ajani UA,Mitchell BD (1997) Familial aggregation of age-related maculopathy. Am J Ophthalmol 123: 199–206

    Google Scholar 

  • Seddon JM et al. (2001) Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol 119: 1191–1199

    PubMed  CAS  Google Scholar 

  • Silvestri G,Johnston PB, Hughes AE (1994) Is genetic predisposition an important risk factor in age-related macular degeneration? Eye 8: 564–568

    Article  Google Scholar 

  • Smiddy WE, Fine SL (1984) Prognosis of patients with bilateral macular drusen. Ophthalmology 91: 271–277

    PubMed  CAS  Google Scholar 

  • Smith W, Mitchell P (1996) Alcohol intake and age-related maculopathy. Am J Ophthalmol 122: 743–745

    PubMed  CAS  Google Scholar 

  • Smith W, Mitchell P,Leeder SR (1996) Smoking and age-related maculopathy. The Blue Mountains Eye Study. Arch Ophthalmol 114: 1518–1523

    Google Scholar 

  • Smith W, Mitchell P, Wang JJ (1997a) Gender, oestrogen, hormone replacement and age-related macular degeneration: results from the Blue Mountains Eye Study. Aust N Z J Ophthalmol 25 [suppl 1]: S13–15

    Article  PubMed  Google Scholar 

  • Smith W, Mitchell P, Rochester C (1997b) Serum beta carotene, alpha tocopherol, and age-related maculopathy: The Blue Mountains Eye Study. Am J Ophthalmol 124: 838–840

    Google Scholar 

  • Smith W et al. (1999) Dietary antioxidants and age-related maculopathy: The Blue Mountains Eye Study. Ophthalmology 106: 761–767

    Article  PubMed  CAS  Google Scholar 

  • Smith W et al. (1998) Plasma fibrinogen levels, other cardiovascular risk factors, and age-related maculopathy:The Blue Mountains Eye Study. Arch Ophthalmol 116: 583–587

    Article  PubMed  CAS  Google Scholar 

  • Smith W, Mitchell P, Leeder SR (2000) Dietary fat and fish intake and age-related maculopathy. Arch Ophthalmol 118: 401–404

    PubMed  CAS  Google Scholar 

  • Smith W et al. (2001) Risk factors for age-related macular degeneration: pooled findings from three continents. Ophthalmology 108: 697–704

    Article  PubMed  CAS  Google Scholar 

  • Solberg Y, Rosner M, Belkin M (1998) The association between cigarette smoking and ocular diseases. Sury Ophthalmol 42: 535–547

    Article  CAS  Google Scholar 

  • Souied EH et al. (1998) The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration. Am J Ophthalmol 125: 353–359

    CAS  Google Scholar 

  • Sperduto RD, Hiller Rand R (1986) Systemic hypertension and age-related maculopathy in the Framingham Study.Arch Ophthalmol 104: 216–219

    CAS  Google Scholar 

  • Sperduto RD, Ferris FL, Kurinij N (1990) Do we have a nutritional treatment for age-related cataract or macular degeneration? Arch Ophthalmol 108: 1403–1405

    Article  PubMed  CAS  Google Scholar 

  • Stone EM et al. (1999) A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Nat Genet 22: 199–202

    Article  PubMed  CAS  Google Scholar 

  • Stryker WS et al. (1988) The relation of diet, cigarette smoking, and alcohol consumption to plasma beta-carotene and alpha-tocopherol levels. Am J Epidemiol 127: 283–296

    PubMed  CAS  Google Scholar 

  • Stur M et al. (1996) Oral zinc and the second eye in age-related macular degeneration. Invest Ophthalmol Vis Sci 37: 1225–1235

    PubMed  CAS  Google Scholar 

  • Sunness JS et al. (1997) Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity. Ophthalmology 104: 1677–1691

    PubMed  CAS  Google Scholar 

  • Sunness JS (1999)The development of choroidal neovascularization in eyes with the geographic atrophy form of age-related macular degeneration. Ophthalmology 106:910–919

    Google Scholar 

  • Sunness JS, Applegate CA, Gonzalez-Baron J (2000) Improvement of visual acuity over time in patients with bilateral geographic atrophy from age-related macular degeneration. Retina 20: 162–169

    Article  PubMed  CAS  Google Scholar 

  • TAP Study Group (1999) Treatment of age-related macular degeneration with photodynamic therapy (TAP). Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials–TAP report. Arch Ophthalmol 117: 1329–1345

    Google Scholar 

  • Taylor HR et al. (1990) Visible light and risk of age-related macular degeneration. Trans Am Ophthalmol Soc 88: 163–173

    PubMed  CAS  Google Scholar 

  • The Eye Disease Case-Control Study Group (1992) Risk factors for neovascular age-related macular degeneration. Arch Ophthalmol 110: 1701–1708

    Google Scholar 

  • Tilanus MA et al. (2000) Relationship between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 238: 482–485

    Article  PubMed  CAS  Google Scholar 

  • Tso MO, Woodford BJ (1983) Effect of photic injury on the retinal tissues. Ophthalmology 90: 952–963

    PubMed  CAS  Google Scholar 

  • Van den Langenberg GM et al. (1998) Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. Am 1 Epidemiol 148: 204–214

    Article  Google Scholar 

  • Van der Schaft TL et al. (1994) Increased prevalence of disci-form macular degeneration after cataract extraction with implantation of an intraocular lens. Br J Ophthalmol 78: 441–445

    Article  PubMed  Google Scholar 

  • Van Newkirk MR et al. (2000) The prevalence of age-related maculopathy: the visual impairment project. Ophthalmology 107: 1593–1600

    Article  Google Scholar 

  • Vidaurri JS et al. (1984) Association between drusen and some of the risk factors for coronary artery disease.Ophthalmologica 188: 243–247

    CAS  Google Scholar 

  • Vinding T (1989) Age-related macular degeneration. Macular changes, prevalence and sex ratio. An epidemiological study of 1000 aged individuals.Acta Ophthalmol 67: 609–616

    CAS  Google Scholar 

  • Vinding T (1990) Pigmentation of the eye and hair in relation to age-related macular degeneration.An epidemiological study of 1000 aged individuals. Acta Ophthalmol 68: 53–88

    CAS  Google Scholar 

  • Vinding T et al. (1992) Risk factor analysis for atrophic and exudative age-related macular degeneration. An epidemiological study of 1000 aged individuals. Acta Ophthalmol 70: 66–72

    CAS  Google Scholar 

  • Vingerling JR et al. (1995a) The prevalence of age-related maculopathy in the Rotterdam Study [see comments]. Ophthalmology 102: 205–210

    PubMed  CAS  Google Scholar 

  • Vingerling JR et al. (1995b) Macular degeneration and early menopause: a case-control study. Bmj 310: 1570–1571

    Article  PubMed  CAS  Google Scholar 

  • Vingerling JR et al. (1995c) Age-related macular degeneration is associated with atherosclerosis. The Rotterdam Study. Am J Epidemiol 142: 404–409

    PubMed  CAS  Google Scholar 

  • Vingerling JR et al. (1996) Age-related macular degeneration and smoking. The Rotterdam Study. Arch Ophthalmol 114: 1193–1196

    Article  PubMed  CAS  Google Scholar 

  • Wang JJ, Mitchell P, Smith W (1998) Refractive error and age-related maculopathy: the Blue Mountains Eye Study. Invest Ophthalmol Vis Sci 39: 2167–2171

    PubMed  CAS  Google Scholar 

  • Webster AR et al. (2001) An analysis of allelic variation in the ABCA4 gene. Invest Ophthalmol Vis Sci 42: 1179–1189

    PubMed  CAS  Google Scholar 

  • Weeks DE et al. (2000) A full genome scan for age-related maculopathy. Hum Mol Genet 9: 1329–1349

    Article  PubMed  CAS  Google Scholar 

  • Weiter JJ (1985) Relationship of senile macular degeneration to ocular pigmentation. Am 1 Ophthalmol 99: 185–187

    CAS  Google Scholar 

  • West Set (1994) Are antioxidants or supplements protective for age-related macular degeneration? Arch Ophthalmol 112: 222–227

    Article  PubMed  CAS  Google Scholar 

  • West SK et al. (1989) Exposure to sunlight and other risk factors for age-related macular degeneration.Arch Ophthalmol 107: 875–879

    CAS  Google Scholar 

  • Witteman JC et al. (1989) Increased risk of atherosclerosis in women after the menopause. BMJ 298: 642–644

    Article  PubMed  CAS  Google Scholar 

  • Young RW (1988) Solar radiation and age-related macular degeneration. Sury Ophthalmol 32: 252–269

    Article  CAS  Google Scholar 

  • Zemel PC, Sowers JR (1990) Relation between lipids and atherosclerosis: epidemiologic evidence and clinical implications.Am J Cardiol 66: 71–121

    Google Scholar 

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Klaver, C.C.W., van Leeuwen, R., Vingerling, J.R., de Jong, P.T.V.M. (2004). Epidemiologie. In: Altersabhängige Makuladegeneration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05681-3_1

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