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Genetische Aspekte von Alkoholismus und alkoholassoziierten Organschäden

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Book cover Alkohol und Alkoholfolgekrankheiten

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Zusammenfassung

Der Konsum alkoholischer Getränke nimmt vor allem in der westlichen Welt stetig zu. Die Ursache hierfür ist noch immer nicht ganz geklärt: Faktoren wie Umwelteinflüsse, Alkoholverbrauch, Trinkdauer, Verhaltensnormen, der soziokulturelle Background, die Möglichkeit, Alkohol zu erwerben, sowie familiäre Hintergründe, genetische Veranlagung und die Stoffwechsellage eines Individuums beeinflussen den Alkoholkonsum. Ein großer Teil der Bevölkerung ist dazu in der Lage, in sozial angemessener Form mit der Droge umzugehen, andere Individuen hingegen haben größere Probleme und geraten in eine schwere Abhängigkeit, in deren Folge sich soziale, physische und psychische Leiden ergeben. Um eine ursachenorientierte Therapie zu entwickeln, versuchen Wissenschaftler herauszufinden, was den Unterschied zwischen diesen Menschen ausmacht: Führt die individuelle Persönlichkeitsstruktur oder vielleicht die biologisch-genetische Ausstattung zu einem abweichenden Trinkverhalten bzw. zu dessen Folgen?

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Literatur

  • Agarwal DP (1995) Biologisch/genetische Marker für Alkoholismus. In: Soyka M (Hrsg) Biologische Alkoholismus Marker. Chapman & Hall, London, pp 9–22

    Google Scholar 

  • Agarwal DP (1997) Molecular genetic aspects of alcohol metabolism and alcoholism. Pharmacopsychiatry 30: 79–84

    Article  PubMed  CAS  Google Scholar 

  • Agarwal DP, Goedde HW (1990) Alcohol metabolism, alcohol intolerance and alcoholism. Springer-Verlag, Berlin, Heidelberg

    Book  Google Scholar 

  • Agarwal DP, Goedde HW (1992a) Pharmacogenetics of alcohol dehydrogenase (ADH). In: Kalow W (ed) Pharmacogenetics. Pergamon Press, New York, pp 263–280

    Google Scholar 

  • Agarwal DP, Goedde HW (1992b) Medico-biological and genetic studies on alcoholism. Role of metabolic variation and ethnicity on drinking habits, alcohol abuse and alcohol-related mortality. Clin Invest 70: 465–477

    Article  CAS  Google Scholar 

  • Agarwal DP, Goedde HW (1995) Genetische Aspekte des Alkoholstoffwechsels and des Alkoholismus. In: Seitz HK, Lieber CS, Simanowski UA (Hrsg) Handbuch Alkohol, Alkoholismus, Alkoholbedingte Organschäden. Johann Ambrosius Barth, Heidelberg, pp 73–92

    Google Scholar 

  • Agarwal DP, Buda B, Czeizel AE, Goedde HW (1997) Alcohol consumption and alcoholism in Hungary. Akadémia Kiadó, Budapest

    Google Scholar 

  • Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeesawaran P, Nogami H, Briggs AH, Cohn JB (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. J Am Med Assoc 263: 2050–2060

    Article  Google Scholar 

  • Chao YC, Liou SR, Chung YY et al. (1994) Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese men. Hepatology 19: 360–366

    Article  PubMed  CAS  Google Scholar 

  • Chao YC, Youn TH, Tang HS, Hsu CT (1997) Alcoholism and alcoholic organ damage and genetic polymorphism of alcohol metabolizing enzymes in chinese patients. Hepatology 25: 112–117

    Article  PubMed  CAS  Google Scholar 

  • Chen WJ, Loh EW, Hsu YP, Cheng AT (1997) Alcohol dehydrogenase and aldehyde dehydrogenase genotypes and alcoholism among Taiwanese aborigines. Biol Psychiatry 41: 703–709

    Article  PubMed  CAS  Google Scholar 

  • Cloninger CR (1987) Recent advances in family studies of alcoholism. In: Goedde HW, Agarwal DP (eds) Genetics and alcoholism. Alan R Liss Inc, New York, pp 47–60

    Google Scholar 

  • Cohen HL, Porjesz B, Begleiter H, Wang W (1997) Neuroelectric correlates of response production and inhibition in individuals at risk to develop alcoholism. Biol Psychiatry 42: 57–67

    Article  PubMed  CAS  Google Scholar 

  • Cotton NS (5979) The familial incidence of alcoholism: a review. J Stud Alcohol 40: 89–116

    Google Scholar 

  • Couzigou P, Begleiter H, Kiianmaa K, Agarwal DP (1993) Genetics and alcohol: In: Verschuren PM (ed). Health issues related to alcohol consumption. ILSI Europe, Brussels, pp 281–329

    Google Scholar 

  • Day CP, Bashir R, James OFW, Bassendine MF, Crabb DW, Thomasson HR, Li TK, Edenberg HJ (1991) Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage. Hepatology 14: 798–805

    Article  PubMed  CAS  Google Scholar 

  • Dinwiddie SH, Cloninger CR (1989) Family and adoption studies of alcoholism. In: Goedde HW, Agarwal DP (eds) Alcoholism: biomedical and genetic aspects. Pergamon Press, New York, pp 259–276

    Google Scholar 

  • Enomoto N, Takase S, Yashuhara M, Takada A (1991) Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol Clin Exp Res 15: 145–144

    Article  Google Scholar 

  • Ferguson RA, Goldberg DM (5997) Genetic markers of alcohol abuse. Clin Chim Acta 247: 599–250

    Google Scholar 

  • Goedde HW, Agarwal DP (5992) Pharmacogenetics of aldehyde dehydrogenase. In: Kalow W (ed) Pharmacogenetics. Perga-mon Press, New York, pp 281–355

    Google Scholar 

  • Goedde HW, Harada S, Agarwal DP (1979) Racial differences in alcohol sensitivity: a new hypothesis. Hum Genet 51331–334

    Google Scholar 

  • Goedde HW, Agarwal DP, Fritze G (1992) Distribution of ADH2 and ALDH2 genotypes in different populations. Hum Genet 88: 344–346

    Article  PubMed  CAS  Google Scholar 

  • Goldman D (1995) Candidate genes in alcoholism. Clin Neurosci 3174–181

    Google Scholar 

  • Gordis E (1997) Genes and environment in complex diseases: a focus on alcoholism. Mol Psychiatry 2: 282–286

    Article  PubMed  CAS  Google Scholar 

  • Heath AC, Bucholz KK, Madden PA, Dinwiddie (1997) Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol Med 27: 1381–1396

    CAS  Google Scholar 

  • Higuchi S, Matsushita S, Muramatsu T, Murayama M, Hayashida M (1996a) Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese. Alcohol Clin Exp Res 20: 493–497

    Article  PubMed  CAS  Google Scholar 

  • Higuchi S, Muramatsu T, Matsushita S, Murayama M, Hayashida M (1996b) Polymorphisms of ethanol-oxidizing enzymes in alcoholics with inactive ALDH2. Hum Genet 97: 431–434

    Article  PubMed  CAS  Google Scholar 

  • Hill SY, Armstrong J, Steinhauer SR, Baughman T, Zubin J (1987) Static ataxia as a psychobiological marker for alcoholism. Alcohol Clin Exp Res 11: 345–348

    Article  PubMed  CAS  Google Scholar 

  • Hill SY (1992) Absence of paternal sociopathy in the etiology of severe alcoholism: is there a Type III alcoholism? J Stud Alcohol 53: 161–169

    PubMed  CAS  Google Scholar 

  • Hill SY (1995) Vulnerability to alcoholism in women. Genetic and cultural factors. Recent Dev Alcohol 12: 9–28

    Article  PubMed  CAS  Google Scholar 

  • Hill SY, Muka D (1996) Childhood psychopathology in children from families of alcoholic female probands. J Am Acad Child Adolesc Psychiatry 35: 725–733

    Article  PubMed  CAS  Google Scholar 

  • Kendler KS, Neale MC, Heath AC, Kessler RC, Eaves LJ (1994) A twin-family study of alcoholism in women. Am J Psychiatry 151: 707–715

    PubMed  CAS  Google Scholar 

  • Lawford BR, Young RM, Rowell JA, Gibson JN (1997) Association of the D2 dopamine receptor Al allele with alcoholism: medical severity and alcoholism and type of controls. Biol Psychiatry 41: 386–393

    Article  PubMed  CAS  Google Scholar 

  • Martin NG (1987) Genetic differences in drinking habits, alcohol metabolism and sensitivity in unselected samples of twins. In: Goedde HW, Agarwal DP (eds) Genetics and alcoholism. Alan R Liss Inc, New York, pp 109–120

    Google Scholar 

  • Matsumoto M, Takahashi H, Maruyama K, Higuchi S, Matsushita S, Muramatsu T, Okuyama K, Yokoyama A, Nakano M, Ishii H (1996) Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. Alcohol Clin Exp Res 20 (Suppl): 289A - 292A

    Article  PubMed  CAS  Google Scholar 

  • Nakamura K, Iwahashi K, Matsuo Y, Miyatake R, Ichikawa Y, Suwaki H (1997) Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase. Jpn J Hum Genet 42: 187–191

    Article  Google Scholar 

  • O’Connor S, Bauer L, Tasman A, Hesselbrock V (1994) Reduced P3 amplitudes are associated with both a family history of alcoholism and antisocial personality disorder. Prog Neuropsychopharmacol Biol Psychiatry 18: 1307–1321

    Article  PubMed  Google Scholar 

  • Reed T, Page WF, Viken RJ, Christian JC (1996) Genetic predisposition to organ-specific endpoints of alcoholism. Alcohol Clin Exp Res 20: 1528–1533

    Article  PubMed  CAS  Google Scholar 

  • Schuckit MA, Smith TL (1996) An 8-year follow-up of sons of alco- holics and control subjects. Arch Gen Psychiatry 53: 202–210

    Article  PubMed  CAS  Google Scholar 

  • Shen YC, Fan JH, Edenb erg HJ, Li TK, Cui YH, Wang YF, Tian CH, Zhou CF, Zhou RL, Wang J, Zhao ZL, Xia GY (1997) Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. Alcohol Clin Exp Res 21: 1272–1277

    Article  PubMed  CAS  Google Scholar 

  • Sigvardsson S, Bohman M, Cloninger CR (1996) Replication of the Stockholm Adoption Study of alcoholism. Confirmatory cross-fostering analysis. Arch Gen Psychiatry 53: 681–687

    Article  PubMed  CAS  Google Scholar 

  • Tabakoff B, Whelan JP, Hoffman PL (1990) Two biological markers of alcoholism. In: Cloninger CR, Begleiter H (eds) Genetics and biology of alcoholism: Banbury Report 33. Cold Spring Harbor Laboratory Press, New York, pp 195–204

    Google Scholar 

  • Tanaka F, Shiratori Y, Yokosuka O, Imazeki F, Tsukada Y, Omata M (1996a) High incidence of ADH2*1/ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease. Hepatology 23: 234–239

    Article  PubMed  CAS  Google Scholar 

  • Tanaka F, Shiratori Y, Yokosuka O, Imazeki F, Tsukada Y, Omata M (1996b) Polymorphism of alcohol-metabolizing genes affect drinking behavior and alcoholic liver disease in Japanese men. Alcohol Clin Exp Res 21: 596–601

    Article  Google Scholar 

  • Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li TK, Wang SP (1991a) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48: 677–681

    PubMed  CAS  Google Scholar 

  • Thomasson HR, Li TK, Edenberg HJ (1991b) Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage. Hepatology 14: 798–801

    Article  PubMed  Google Scholar 

  • Yamauchi M, Maezawa Y, Mizuhara Y, Ohata M, Hirakawa J, Nakajima H, Toda G (1995) Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis. Hepatology 22: 1136–1142

    PubMed  CAS  Google Scholar 

  • Yuan H, Marazita ML, Hill SY (1996) Segregation analysis of alcoholism in high density-families: a replication. Med Genet 67: 71–76

    Article  CAS  Google Scholar 

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Authors
  1. Dharam P. Agarwal
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  2. Kamayni Agarwal-Kozlowski
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Editors and Affiliations

  1. IV. Medizinische Universitätsklinik (Schwerpunkt Gastroenterologie und Hepatologie), Fakultät für Klinische Medizin Mannheim, Universität Heidelberg, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1-3, D-68167, Mannheim, Deutschland

    Manfred V. Singer  & Stephan Teyssen  & 

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© 1999 Springer-Verlag Berlin Heidelberg

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Agarwal, D.P., Agarwal-Kozlowski, K. (1999). Genetische Aspekte von Alkoholismus und alkoholassoziierten Organschäden. In: Singer, M.V., Teyssen, S. (eds) Alkohol und Alkoholfolgekrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05657-8_9

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  • DOI: https://doi.org/10.1007/978-3-662-05657-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05658-5

  • Online ISBN: 978-3-662-05657-8

  • eBook Packages: Springer Book Archive

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