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Zusammenfassung

Ethanol ist ein kleines wasserlösliches Molekül und kann deshalb in alle Gewebe des Körpers eindringen. In der Regel (wie auch in diesem Kapitel) wird Ethanol mit dem Begriff Alkohol gleichgesetzt und in, Form alkoholischer Getränke konsumiert. Dieses Kapitel gibt einen allgemeinen Überblick über den Ethanolstoffwechsel. Es werden die verschiedenen enzymatischen Reaktionen, die Pharmakokinetik des Ethanols sowie verschiedene Faktoren beschrieben, die den Stoffwechsel und die Pharmakokinetik beeinflussen.

Danksagung: Diese Arbeit entstand mit finanzieller Unterstützung der Niederländischen Stiftung für Alkoholforschung (SAR).

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Literatur

  • Adachi J, Mizoi Y (1983) Acetaldehyde-mediated alcohol sensitivity and elevation of plasma catecholamine in man. Jpn J Pharmacol 33: 535–39

    Article  Google Scholar 

  • Ammon A, Shafer C, Hofmann U, Klotz U (1996) Disposition and first-pass metabolism of ethanol in humans: Is it gastric or hepatic and does it depend on gender? Clin Pharmacol Ther 59: 503–13

    Article  PubMed  CAS  Google Scholar 

  • Caballeria J (1992) First-pass metabolism of ethanol: Its role as a determinant of blood alcohol levels after drinking. HepatoGastroenterol 39: 62–6 (Suppl 1)

    Google Scholar 

  • Clark ER, Hugnes JE, Letley E (1973) The effect of oral administration of various sugars on blood ethanol concentrations in man. J Pharm Pharmacol 25: 319–23

    Article  PubMed  CAS  Google Scholar 

  • Dean RA, Christian CD, Sample RH, Bosron WF (1991) Human liver cocaine esterases: Ethanol-mediated formation of ethyl-cocaine. FASEB J 5: 2735–39

    Google Scholar 

  • Dohmen K, Baranoa E, Ishibashi H et al. (1996) Ethnic differences in gastric-alcohol dehydrogenase activity and ethanol first-pass metabolism. Alcohol Clin Exp Res 20: 1569–76

    Article  PubMed  CAS  Google Scholar 

  • Domschke S, Domschke W, Lieber CS (1974) Hepatic redox state: Attenuation of the acute effects of ethanol induced by chronic ethanol consumption. Life Sci 15: 1327–34

    Google Scholar 

  • Dubowski KM (1985) Absorption, distribution and elimination of alcohol: highway safety aspects. J Stud Alcohol 10 (suppl): 98–108

    CAS  Google Scholar 

  • Erickson CK (1993) Lowering of blood ethanol by activated carbon products in rats and dogs. Alcohol 10: 103–7

    Article  PubMed  CAS  Google Scholar 

  • Frezza M, Padova C di, Pozzato G, Terpin M, Baraona E, Lieber CS (1990) High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N Engl J Med 322: 95–9

    Google Scholar 

  • Gentry RT, Baranoa E, Lieber CS (1994) Agonist: gastric first pass metabolism of alcohol. J Lab Clin Med 123: 21–6

    PubMed  CAS  Google Scholar 

  • Giles HG, Sandrin S, Saldivia V, Israel Y (1988) Noninvasive estimation of blood alcohol concentrations: ethanol vapor above the eye. Alcohol Clin Exp 12: 255–258

    Article  CAS  Google Scholar 

  • Goedde HW, Agarwal DP, Fritze G et al. (1992) Distribution of ADH, and ALDH2 genotypes in different populations. Hum Genet 88: 344–6

    Article  PubMed  CAS  Google Scholar 

  • Goist KC Jr, Sutker PB (1985) Acute alcohol intoxication and body composition in women and men. Pharmacol Biochem Behav 22: 811–14

    Article  PubMed  Google Scholar 

  • Gullberg RG (1991) Statistical evaluation and reporting of blood alcohol/breath alcohol ratio distribution data. J Anal Toxico 115: 343–44

    Google Scholar 

  • Haber PS, Gentry T, Mak KM, Mirmiran-Yazdy SAA, Greenstein RJ, Lieber S (1996) Metabolism of alcohol by human gastric cells: relation to first-pass metabolism. Gastroenterology 111: 863–70

    Article  PubMed  CAS  Google Scholar 

  • Hannak D, Bartelt U, Kattermann R (1985) Acetate formation after short-term ethanol administration in man. Biol Chem Hoppe Seyler 366: 749–53

    Article  PubMed  CAS  Google Scholar 

  • Hearn WL, Flynn DD, Hirne GW et al. (1991) A unique cocaine metabolite displays high affinity for the dopamine transporter. J Neurochem 56: 698–701

    Article  PubMed  CAS  Google Scholar 

  • Hendriks HFJ, Veenstra J, Velthuis-te Wierik EJM, Schaafsma G, Kluft C (1994) Effect of moderate dose of alcohol with evening meal on fibrinolytic factors. BMJ 308: 1003–6

    Article  PubMed  CAS  Google Scholar 

  • Holford NHG (1987) Clinical pharmacokinetics of ethanol. Clinical Pharmacokinetics 13: 273–92

    Article  PubMed  CAS  Google Scholar 

  • Höög JO, Brandt M (1995) Mammalian class VI alcohol dehydrogenase. Novel types of the rodent enzymes. Adv Exp Med Biol 372: 355–64

    Google Scholar 

  • Horowitz M, Maddox A, Bochner M et al. (1989) Relationships between gastric emptying of solid and caloric liquid meals and alcohol absorption. Am J Phys 257: G291 - G298

    CAS  Google Scholar 

  • Israel Y, Valenzuela JE, Salazar I, Ugarte G (1969) Alcohol and amino acid transport in the human small intestine. J Nutr 98: 222–4

    PubMed  CAS  Google Scholar 

  • Janus ED, Sharman JR (1972) Milk and blood alcohol. N Z Med J 75: 339–42

    PubMed  CAS  Google Scholar 

  • Jones AW (1992) Ethanol distribution ratios between urine and capillary blood in controlled experiments and in apprehended drinking drivers. J Forens Sci 37: 21–34

    CAS  Google Scholar 

  • Jones AW (1991) Concentration-time profiles of ethanol in capil- lary blood after ingestion of beer. J Forens Sci Soc 31: 429–39

    Article  CAS  Google Scholar 

  • Jones AW (1993) Pharmacokinetics of ethanol in saliva: Comparison with blood and breath alcohol profiles, subjective feelings of intoxication, and diminished performance. Clin Chem 39: 1837–44

    PubMed  CAS  Google Scholar 

  • Jones AW, Neri A (1985) Age-related differences in blood ethanol parameters and subjective feelings of intoxication in healthy men. Alcohol Alcohol 20: 45–52

    PubMed  CAS  Google Scholar 

  • Jones AW, Jönsson K, Kechagias S (1997) Effect of high-fat, high-protein and high-carbohydrate meals on the pharmacokinetics of a small dose of ethanol. Br J Clin Pharmacol 44: 521–26

    Article  PubMed  CAS  Google Scholar 

  • Jörnvall H, Höög J-O (1995) Nomenclature of alcohol dehydrogenases. Alcohol Alcohol 3o: 153–61

    Google Scholar 

  • Kalant H (1996) Pharmacokinetics of ethanol: absorption, distribution and elimination. In: Begleiter H, Kissin B (eds) The pharmacology of alcohol and alcohol dependence. Oxford University press, New York, pp 15–58

    Google Scholar 

  • Kijewski H, Sprung R, Eggert A (1991) Zur Verfälschung der Messung der Atemalkoholkonzentration. Ein experimenteller and kasuistischer Beitrag. Blutalkohol 28: 243–51

    Google Scholar 

  • Kohlenberg-Müller K, Bitsch I (1990) Neue Methoden zur pharmakokinetischen Beschreibung des Alkohols ind seiner Metaboliten bei weiblichen and männlichen Versuchsperonen. Blutalkohol 27: 40–48

    PubMed  Google Scholar 

  • Laposata E, Lange LG (1986) Presence of nonoxidative metabolism in human organs commonly damaged by ethanol abuse. Science 231: 497–99

    Article  PubMed  CAS  Google Scholar 

  • Levitt MD, Levitt DG (1994) The critical role of the rate of ethanol absorption in the interpretation of studies purporting to demonstrate gastric metabolism of ethanol. J Pharm Exp Ther 269: 297–304

    CAS  Google Scholar 

  • Levitt MD, Li R, DeMaster EG, Elson M, Furne J, Levitt DG (1997) Use of measurements of ethanol absorption from stomach and human intestine to asses ethanol metabolism. Am J Physiol 273: G951 - G957

    PubMed  CAS  Google Scholar 

  • Li T-K, Bosron WF, Dafeldecker WP, Lange LG, Vallee BL (1977) Isolation of II-alcohol dehydrogenase of human liver: Is it a determinant of alcoholism? Proc Nat Ac Sci USA 74: 4378–81

    Article  CAS  Google Scholar 

  • Lieber CS (1997) Ethanol metabolism, cirrhosis and alcoholism. Clinica Chimica Acta 257: 59–84

    Article  CAS  Google Scholar 

  • Lieber CS, Jones DP, Losowsky MS, Davidson CS (1962) Interrelation of uric acid and ethanol metabolism in man. J Clin Invest 41: 1863–70

    Article  PubMed  CAS  Google Scholar 

  • Lieber CS, Teschke R, Hasamura Y, DeCarli LM (1975) Differences in hepatic and metabolic changes after acute and chronic alcohol consumption. Fed Proc 34: 2060–74

    PubMed  CAS  Google Scholar 

  • Martin E, Moll W, Schmidt P, Dettli L (1984) The pharmacokinetics of alcohol in human breath, venous and arterial blood after oral ingestion. Eur J Clin Pharmacol 26: 619–26

    Article  PubMed  CAS  Google Scholar 

  • McFarlane A, Pooley L. Welch IM, Rumsey RD, Read NW (1986) How does dietary lipid lower blood alcohol concentrations? Gut 27: 15–8

    Article  PubMed  CAS  Google Scholar 

  • Miller DS, Stirling JL,Yudkin J (1966) Effect of ingestion of milk on concentrations of blood alcohol. Nature 212: 1051

    Google Scholar 

  • Moore R (1991) Concerning breath alcohol measurements during absorption and elimination. J Anal Toxicol 15: 346–47

    PubMed  CAS  Google Scholar 

  • Parés X, Farrés J (1996) Alcohol and aldehyde dehydrogenase in the gastrointestinal tract. In: Preedy VR, Watsons RR (eds) Alcohol and the gastrointestinal tract. CRC Press, Boca Raton, Pp 41–56

    Google Scholar 

  • Pikaar NA, Wedel M, Hermus RJ (1988) Influence of several factors on blood alcohol conentrations after drinking alcohol. Alcohol Alcohol 23: 289–97

    PubMed  CAS  Google Scholar 

  • Pozzato G, Moretti M, Franzin F et al. (1995) Ethanol mechanism and aging: the role of »first pass metabolism« and gastric alcoholdehydrogenase activity. J Gerontology 50 A: B135–41

    Google Scholar 

  • Roine RP, Gentry RT, Lim RT, Helkkonen E, Salaspuro M, Lieber CS (1993) Comparison of blood alcohol concentrations after beer and whiskey. Alcoholism. Clin Exp Res 17: 709–11

    Google Scholar 

  • Seitz HK, Oneta CM (1998) Gastrointestinal alcohol dehydrogenase. Nutrition Reviews 56: 52–60

    Article  PubMed  CAS  Google Scholar 

  • Seitz HK, Egerer G, Simanowski UA et al. (1993) Human gastric alcohol dehydrogenase activity: effect of age, sex and alcoholism. Gut 34: 1433–37

    Article  PubMed  CAS  Google Scholar 

  • Siegers CP, Strubelt O, Back G (1972) Inhibition by caffeine of ethanol absorption in rats. J Eur Parmacol 20: 181–87

    Article  CAS  Google Scholar 

  • Singer MV, Eysselein V, Goebell H (1983) Beer and wine but not whisky and pure ethanol do stimulate release of gastrin in humans. Digestion 26: 73–79

    Article  PubMed  CAS  Google Scholar 

  • Suokas A, Kupari M, Heikkila J, Lindros K, Ylikahri R (1988) Acute cardiovascular and metabolic effects of acetate in men. Alcohol Clin Exp Res 12: 52–58

    Article  PubMed  CAS  Google Scholar 

  • Sweeny GD (1990) High blood alcohol levels in women. N Engl J Med 323: 58–9

    Article  Google Scholar 

  • Teschke R, Gellert J (1986) Hepatic microsomal ethanol-oxidizing system (MEOS): metabolic aspects and clinical implications. Alcohol Clin Exp Res 10: Szo-32

    Google Scholar 

  • Thurman RG, Handler JA (1989) New perspectives in catalasedependent ethanol metabolism. Drug Metab Rev 20: 679–88

    Article  PubMed  CAS  Google Scholar 

  • Trémolières J, Lowy R, Griffaton G (1972) Metabolic effects of ethanol. Proc Nutr Soc 31: 107–15

    Article  PubMed  Google Scholar 

  • Wagner FJ, Parés X, Holmquist B, Vallee BL (1984) Physical and enzymatic properties of a class III isozyme of human liver alcohol dehydrogenase: c-ADH. Biochemistry 23: 21–93

    Google Scholar 

  • Watson PE, Watson ID, Batt RD (1981) Prediction of blood alcohol concentration in human subjects; updating the Widmark equation. J Stud Alcohol 42: 547–56

    PubMed  CAS  Google Scholar 

  • Wilkinson PK (1980) Pharmacokinetics of ethanol: a review. Alcoholism: Clinical and Experimental Research 4: 6–21

    Article  CAS  Google Scholar 

  • Wilkinson PK, Sedman AJ, Sakmar E, Kay DR, Wagner JG (1977) Pharmacokinetics of ethanol after oral administration in the fasting state. J Pharmacokinetics Biopharmaceutics 5: 207–24

    Article  CAS  Google Scholar 

  • Yasunami M, Chen C-S, Yoshida A (1991) A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. Proc Natl Acad Sci USA 88: 7610

    Article  PubMed  CAS  Google Scholar 

  • Yin S-J, Wang M-F, Liao C-S, Chen C-M, Wu C-W (1990) Identification of a human stomach alcohol dehydrogenase with distinctive kinetic properties. Biochem Int 22: 829–835

    PubMed  CAS  Google Scholar 

  • Yin S-J, Liao C-S, Wu C-W et al. (1997) Human stomach alcohol and aldehyde dehydrogenases: comparison of expression patters and activities in alimentary tract. Gastroenterology 112: 766–775

    Article  PubMed  CAS  Google Scholar 

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van Haaren, M.R.T., Hendriks, H.F.J. (1999). Alkoholstoffwechsel. In: Singer, M.V., Teyssen, S. (eds) Alkohol und Alkoholfolgekrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05657-8_8

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  • DOI: https://doi.org/10.1007/978-3-662-05657-8_8

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