Skip to main content
SpringerLink
Log in
Book cover

Alkohol und Alkoholfolgekrankheiten pp 283–294Cite as

Alkohol und Stoffwechsel

  • Chapter

Zusammenfassung

Spätestens seit der Beschreibung des Zieve-Syndroms sind die unterschiedlichen Effekte des Alkohols auf den Fettstoffwechsel bekannt. Die Alkoholeffekte auf die High-density-Lipoproteine (HDL) und die damit verbundene mögliche Verminderung des Koronarrisikos sind allen Alkoholkonsumenten geläufig. Letzterer Alkoholeffekt wird auch oftmals als Rechtfertigung des Alkoholkonsums aufgeführt. Weitaus weniger bekannt ist, daß der Alkohol alle Fettfraktionen des Blutes zu beeinflussen vermag. Die akute und die chronische Einnahme von Alkohol führt durch verschiedenste direkte und indirekte Mechanismen zu Veränderungen im Stoffwechsel der Fette. Die Form des Alkohols, d. h. konsumiert als Wein, Bier oder Schnaps, spielt dabei praktisch keine Rolle. Akute Alkoholeffekte sind von chronischen Effekten zu unterscheiden. Daß Alkohol eine ausgeprägte Störung des Lipidstoffwechsels zu induzieren vermag, illustriert auch der klinische Zustand der Leberverfettung (Steatose) (s. Kap. 19).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Ames BN, Cathcart R, Schwiers E, Hochstein P (1981) Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer. A hypothesis. Proc Natl Acad Sci USA 78: 6858–6862

    Article  CAS  Google Scholar 

  • Ansari GAS, Kaphalia BS, Khan MF (1995) Fatty acid conjugates of xenobiotics. Toxicology Letters 75: 1–17

    Article  PubMed  CAS  Google Scholar 

  • Becker BF (1993) Towards the physiological function of uric acid. Free Rad Biol Med 14: 615–631

    Article  PubMed  CAS  Google Scholar 

  • Björntorp P (1991) Adipose tissue distribution and function. Int J Obesity 15: 67–81

    Google Scholar 

  • Bora PS, Wu X, Spilburg CA, Lange LG (1992) Purification and characterization of fatty acid ethyl ester synthase-II from human myocardium. J Biol Chem 267: 13217–13221

    PubMed  CAS  Google Scholar 

  • Contaldo F, D’Arrigo E, Carandente V, Cortese C, Coltorti A, Mancini M, Taskinen MR, Nikkilä EA (1989) Short-term effects of moderate alcohol consumption on lipid metabolism and energy balance in normal men. Metabolism 38: 166–171

    Article  PubMed  CAS  Google Scholar 

  • Durnin JVGA, Womersley J (1974) Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged 16 to 72 years. Br J Nutr 32: 77–97

    Article  PubMed  CAS  Google Scholar 

  • Emmerson BT (1996) The management of gout. N Engl J Med 334: 445–451

    Article  PubMed  CAS  Google Scholar 

  • Gabuzda GJ, Shear L (1970) Metabolism of dietary protein in hepatic cirrhosis. Am J Clin Nutr 23: 479

    PubMed  CAS  Google Scholar 

  • Haskell WL, Camargo C, Williams PT, Vranizan KM, Krauss RM, Lindgren FT, Wood PD (1984) The effect of cessation and resumption of moderate alcohol intake on serum high density lipoprotein subfractions. A controlled study. N Engl J Med 310: 805–810

    Google Scholar 

  • Hirano K, Yamshita S, Sakai N, Hiraoka H, Ueyama Y, Funahashi T, Matasuzawa Y (1992) Low-density-lipoproteins in hyperalphalipoproteinemic heavy alcohol drinkers have reduced affinity for the low-density-lipoprotein receptor. Clin Biochem 25: 357–362

    Article  PubMed  CAS  Google Scholar 

  • Horsmans Y, Desager JP, van’den-Berge V, Abrassart M, Harvengt C (1993) Effects of simvastatin and pravastatin on 6-b-hydroxycortisol excretion, a potential ma rker of cytochrome P-45o 3A. Pharmacol Res 28: 243–248

    Article  PubMed  CAS  Google Scholar 

  • Iribarren C, Sharp DS, Curb JD, Yano K (1996) High uric acid: a metabolic marker of coronary heart disease among alcohol abstainers. J Clin Epidemiol 49: 673–678

    Article  PubMed  CAS  Google Scholar 

  • Kaneko K, Fujimori S, Akaoka I (1991) Changes caused by ethanol intake on metabolism of hypouricemic agents (combination of allopurinol and benzbromarone). Adv Exp Med Biol 309 A: 139–142

    Google Scholar 

  • Laposata EA, Lange LG (1986) Presence of nonoxodative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science 231: 497–499

    Article  PubMed  CAS  Google Scholar 

  • Lieber CS, Jones DP, Losowsky MS, Davidson CS (1962a) Interrelation of uric acid and ethanol metabolism in man. J Clin Invest 41: 1863–1870

    Article  PubMed  CAS  Google Scholar 

  • Lieber CS, Leevy CM, Stein SW, George WS, Cherrick GR, Abelmann WH, Davidson CS (1962b) Effect of ethanol on plasma free fatty acids in man. J Lab Clin Med 59: 826–832

    PubMed  CAS  Google Scholar 

  • Marth E, Gazzolato G, Bittolo-Bon G, Avogaro P, Kostner GM (1982) Serum concentrations of Lp(a) and other lipoprotein parameters in heavy alcohol consumers. Ann Nutr Metabol 26: 56–62

    Article  CAS  Google Scholar 

  • Nishimura T, Shimizu T, Mineo I, Kawachi M, Ono A, Nakajima H, Kuwajima M, Kona N, Matsuzawa Y (1994) Influence of daily drinking habits on ethanol induced hyperuricemia. Metabolism 43: 745–748

    Article  PubMed  CAS  Google Scholar 

  • Piccirillo VJ, Chambers JW (1976) Inhibition of hepatic uptake of alpha amino-isobutyric acid by ethanol: effects of pyrazole and metabolites of ethanol. Res Commun Chem Pathol Pharmacol 13: 297–309

    PubMed  CAS  Google Scholar 

  • Scott JT (1991) Drug-induced gout. Baillieres Clin Rheumatol 5: 39–60

    Article  PubMed  CAS  Google Scholar 

  • Suter PM, Schutz Y, Jéquier E (1992) The effect of ethanol on fat storage in healthy subjects. N Engl J Med 326: 983–987

    Article  PubMed  CAS  Google Scholar 

  • Suter PM, Maire R, Vetter W (1997) Alcohol consumption: a risk factor for abdominal fat accumulation in men. Add Biol 2: 101–103

    Article  Google Scholar 

  • Swart GR, Ber JW van den; Wattimena JL, Rietveld T,Vuure JK van, Frenkel M (1988) Elevated protein requirements in cirrhosis of the liver investigated by whole body protein turnover studies. Clin Sci 75: 101–107

    CAS  Google Scholar 

  • Takahashi S, Yamamoto T, Moriwaki Y, Tsutsumi Z, Higashino K (1994) Impaired lipoprotein metabolism in patients with primary gout–influence of alcohol intake and body weight. Br J Rheumatol 33: 731–734

    Article  PubMed  CAS  Google Scholar 

  • Takahashi S, Yamamoto T, Moriwaki Y, Tsutsumi Z, Higashino K (1995) Increased concentrations of serum Lp (a) lipoprotein in patients with primary gout. Ann Rheum Dis 54: 90–93

    Article  PubMed  CAS  Google Scholar 

  • Välimäki M, Taskinen MR, Ylikahri R, RoMe R, Kuusi T, Nikkila EA (1988) Comparison of the effects of two different doses of alcohol on serum lipoproteins, HDL-subfractions and apolipoproteins A-1 and A-2: a controlled study. Eur J Clin Invest 18: 472–480

    Article  PubMed  Google Scholar 

  • Välimäki M, Laitinen K, Ylikahri R, Ehnholm C, Jauhiainen M, Bard JM, Fruchart JC, Taskinen MR (1991) The effect of moderate alcohol intake on serum apolipoprotein A-I-containing lipoproteins and lipoprotein (a). Metabolism 40: 1168–1172

    Article  PubMed  Google Scholar 

  • Vandenberg MK, Moxley G, Breitbach SA, Roberts WN (1994) Gout attacks in chronic alcoholics occur at lower serum urate levels than in nonacloholics. J Rheumatol 21: 700–704

    PubMed  CAS  Google Scholar 

  • Wang TW, Byrne CD, Hales CN (1994) Effect of ethanol on hepatic apolipoprotein B synthesis and secretion in vitro. Biochem Biophys Acta 1211: 234–238

    Article  PubMed  CAS  Google Scholar 

  • Webb AR, Newman LA, Taylor M, Keogh JB (1989) Handgrip dynamometry as a predictor of post operative complications: reappraisal using age standardized grip strenghs. J Parent Enteral Nutr 13: 30–33

    Article  CAS  Google Scholar 

  • WHO (1985) Energy and Protein Requirements. Geneva (Switzerland): World Health Organization (WHOM-206

    Google Scholar 

  • Williams PT (1997) Interactive effects of exercise, alcohol, and vegetarian diet on coronary artery disease risk factors in 9242 runners: The National Runners’ Health Study. Am J Clin Nutr 66: 1197–1206

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Paolo M. Suter
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. IV. Medizinische Universitätsklinik (Schwerpunkt Gastroenterologie und Hepatologie), Fakultät für Klinische Medizin Mannheim, Universität Heidelberg, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1-3, D-68167, Mannheim, Deutschland

    Manfred V. Singer  & Stephan Teyssen  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Suter, P.M. (1999). Alkohol und Stoffwechsel. In: Singer, M.V., Teyssen, S. (eds) Alkohol und Alkoholfolgekrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05657-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-05657-8_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05658-5

  • Online ISBN: 978-3-662-05657-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation