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The Coxsackie-Adenovirus Receptor—A New Receptor in the Immunoglobulin Family Involved in Cell Adhesion

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Adenoviruses: Model and Vectors in Virus-Host Interactions

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 273))

Abstract

The physiological and cell biological aspects of the CoxsackieAdenovirus Receptor (CAR) is discussed in this review. The receptor obviously recognizes the group C adenoviruses in vivo, but also fibers from other groups except group B in vitro. The latter viruses seem to utilize a different receptor. The receptor accumulates at, or close to, the tight junction in polarized epithelial cells and probably functions as a cell-cell adhesion molecule. The cytoplasmic tail of the receptor is not required for virus attachment and uptake. Although there is a correlation between CAR and uptake of adenoviruses in several human tumor cells, evidence of an absolute requirement for integrins has not been forthcoming. The implication of these findings for adenovirus gene therapy is discussed.

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Authors and Affiliations

  1. Department of Cell and Molecular Biology, Karolinska Institute, Box 285, 17177, Stockholm, Sweden

    L. Philipson

  2. Karolinska Institute, Ludwig Institute for Cancer Research, Stockholm Branch, Box 240, 17177, Stockholm, Sweden

    R. F. Pettersson

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  1. Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, 91054, Erlangen, Germany

    Walter Doerfler

  2. Institut für Genetik, Universität zu Köln, Weyertal 121, 50931, Köln, Germany

    Petra Böhm

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Philipson, L., Pettersson, R.F. (2004). The Coxsackie-Adenovirus Receptor—A New Receptor in the Immunoglobulin Family Involved in Cell Adhesion. In: Doerfler, W., Böhm, P. (eds) Adenoviruses: Model and Vectors in Virus-Host Interactions. Current Topics in Microbiology and Immunology, vol 273. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05599-1_3

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