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Adenoviruses: Model and Vectors in Virus-Host Interactions pp 97–129Cite as

The Multifunctional Role of E1A in the Transcriptional Regulation of CREB/CBP-Dependent Target Genes

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 272))

Abstract

Oncoproteins encoded by the early region lA (E1A) of adenoviruses (Ads) have been shown to be powerful tools to study gene regulatory mechanisms. As ElA proteins lack a sequence-specific DNA-binding activity, they modulate viral and cellular gene expression by interacting directly with a diverse array of cellular factors, among them sequence-specific transcription factors, proteins of the general transcription machinery, co-activators and chromatin-modifying enzymes. By making use of these factors, E1A affects major cellular events such as cell cycle control, differentiation, apoptosis, and oncogenic transformation. In this review we will focus on the interaction of E1A with cellular components involved in the cAMP/PKA signal transduction pathway and we will discuss the consequences of these interactions in respect to the activation of CREB/CBP-dependent target genes.

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  1. Institute of Molecular Biology (Cancer Research), University of Essen Medical School, Hufelandstraße 55, 45122, Essen, Germany

    D. Brockmann & H. Esche

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  1. Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, 91054, Erlangen, Germany

    Walter Doerfler

  2. Institut für Genetik, Universität zu Köln, Weyertal 121, 50931, Köln, Germany

    Petra Böhm

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Brockmann, D., Esche, H. (2003). The Multifunctional Role of E1A in the Transcriptional Regulation of CREB/CBP-Dependent Target Genes. In: Doerfler, W., Böhm, P. (eds) Adenoviruses: Model and Vectors in Virus-Host Interactions. Current Topics in Microbiology and Immunology, vol 272. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05597-7_4

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