The Adrenergic Response to Cardiopulmonary Bypass
It is generally believed that catecholamine secretion is increased during cardiopulmonary bypass. It has been suggested that this progressive rise in plasma catecholamines is responsible for the irreversible shock-like state, with myocardial failure and low-output syndromes, occasionally seen in patients undergoing this procedure. Three causes of increased catecholamine production have been suggested to be associated with relative inefficiency of tissue perfusion during bypass, the effect of acute haemodilution in causing lightening of the plane of anaesthesia and the general stress induced by surgery.
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