Central 5-HT4 Receptors: Electrophysiology
Serotonin receptors of the 5-HT4 subtypes are expressed at relatively high densities in several regions of the mammalian central nervous system. As such, these receptors are likely to participate in at least some of the functions served by serotonin in the brain. The challenge is to identify, at a behavioral level, those processes involving 5-HT4 receptors and to elucidate, at cellular and molecular levels, how these processes are made possible by 5-HT4 receptor activation. In this regard, the electrophysiological effects mediated by 5-HT4 receptors constitute an important middle ground. 5-HT4 receptors regulate the electrophysiological properties of individual neurons; thus in turn, the functioning of neuronal networks. It is ultimately the effect of 5-HT4 receptors on the functioning of these networks that impact behavioral and thought processes.
KeywordsAdenylate Cyclase Pyramidal Cell Serotonin Receptor Mammalian Central Nervous System Hippocampal Pyramidal Cell
Unable to display preview. Download preview PDF.
- 2.Biscoe TJ, Straughan DW. Micro-electrophoretic studies of neurones in the cat hippocampus. J Physiol (London) 1966; 183: 341–359.Google Scholar
- 3.Segal M. The action of serotonin in the rat hippocampal slice preparation. J Physiol (London) 1980; 303: 423–439.Google Scholar
- 9.Andrade R, Nicoll RA. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J Physiol (London) 1987; 39:499–124.Google Scholar
- 30.Torres GE, Arfken CL, Andrade R. 5-hydroxytryptamine4 receptors reduce afterhyperpolarization in hippocampus by inhibiting calcium-induced calcium release. Mol Pharmacol 1996; (in press).Google Scholar
- 36.Takahashi T, Berger AJ. Direct excitation of rat spinal motoneurones by serotonin. J Physiol (London) 1990; 423: 63–76.Google Scholar
- 37.Andrade R, Haj-Dahmane S, Chapin EM. On the mechanim underlying the 5-HT4 receptor-induced depolarization in rat hippocampus. [Abstract] Soc Neurosci Abstr 1997; (in press).Google Scholar
- 39.Fagni L, Dumuis A, Sebben M et al. The 5-HT4 receptor subtype inhibits K+ current in colliculi neurones via activation of a cyclic AMP-dependent protein kinase. Eur J Pharmacol 1992; 105: 973–9.Google Scholar