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Functional Expression of CXCR4 in S. cerevisiae: Development of Tools for Mechanistic and Pharmacologic Studies

  • Conference paper
Chemokine Roles in Immunoregulation and Disease

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 45))

  • 62 Accesses

Abstract

Chemokines are cytokines that program directed migration of leukocyte subsets (Loetscher et al. 2000). These small proteins (~8–14 kDa) form the largest family of secreted intercellular messengers, having over 43 members recognized at this time. The family is characterized by the presence of four positionally conserved cysteine residues and subdivided into four branches based on the relationship of the two amino-proximal cysteines: C-C, C-X-C, C-X3-C, and C. Cellular signals for chemokines are transduced by members of the G-protein coupled receptor (GPCR) family that also cosegregate along these four subdivisions (Murphy et al. 2000). It is now recognized that in addition to promoting inflammation through recruitment of leukocyte subsets, chemokines play a central role in directing the development of tissues outside the hemato-lymphoid system.

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Authors
  1. W.-B. Zhang
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  2. Z.-X. Wang
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  3. J. L. Murray
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  4. N. Fujii
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  5. J. Broach
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  6. S. C. Peiper
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Editor information

Editors and Affiliations

  1. Department of Immunology, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA, 94804, USA

    R. Horuk

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© 2004 Springer-Verlag Berlin Heidelberg

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Zhang, WB., Wang, ZX., Murray, J.L., Fujii, N., Broach, J., Peiper, S.C. (2004). Functional Expression of CXCR4 in S. cerevisiae: Development of Tools for Mechanistic and Pharmacologic Studies. In: Murphy, P.M., Horuk, R. (eds) Chemokine Roles in Immunoregulation and Disease. Ernst Schering Research Foundation Workshop, vol 45. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05403-1_9

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  • DOI: https://doi.org/10.1007/978-3-662-05403-1_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05405-5

  • Online ISBN: 978-3-662-05403-1

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