Chemokines and Inflammatory Skin Diseases

  • B. Homey
  • E. Bünemann
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 45)

Abstract

Accumulating evidence indicates that chronically relapsing inflammatory skin diseases such as atopic dermatitis and psoriasis are T cell-mediated diseases. Thus, understanding the underlying mechanisms of memory T cell homing to the skin may provide promising targets for the development of novel therapeutics to interfere with inflammatory processes of the skin. Chemokines, a superfamily of small cytokine-like, chemotactic proteins, have recently been shown to critically regulate leukocyte trafficking. Here we summarize results of recent studies associating chemokines with a psoriatic or atopic dermatitis phenotype and delineating their role in the recruitment of memory T cells to the skin.

Keywords

Nickel Migration Arthritis Dust Filtration 

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© Springer-Verlag Berlin Heidelberg 2004

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  • B. Homey
  • E. Bünemann

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