Skip to main content
SpringerLink
Log in

Chemokines and Inflammatory Skin Diseases

  • Conference paper
Book cover Chemokine Roles in Immunoregulation and Disease

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 45))

Abstract

Accumulating evidence indicates that chronically relapsing inflammatory skin diseases such as atopic dermatitis and psoriasis are T cell-mediated diseases. Thus, understanding the underlying mechanisms of memory T cell homing to the skin may provide promising targets for the development of novel therapeutics to interfere with inflammatory processes of the skin. Chemokines, a superfamily of small cytokine-like, chemotactic proteins, have recently been shown to critically regulate leukocyte trafficking. Here we summarize results of recent studies associating chemokines with a psoriatic or atopic dermatitis phenotype and delineating their role in the recruitment of memory T cells to the skin.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baekkevold ES, Yamanaka T, Palframan RT, Carlsen HS, Reinholt FP, et al (2001) The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J Exp Med 193:1105–1112

    Article  PubMed  CAS  Google Scholar 

  • Bata-Csorgo Z, Hammerberg C, Voorhees JJ, Cooper KD (1995) Intralesional T lymphocyte activation as a mediator of psoriatic epidermal hyperplasia. J Invest Dermatol 105:89S-94S

    Article  PubMed  CAS  Google Scholar 

  • Berg EL, Yoshino T, Rott LS, Robinson MK, Warnock RA, et al (1991) The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. J Exp Med 174:1461–1466

    Article  PubMed  CAS  Google Scholar 

  • Bos JD, Van Leent EJ, Sillevis Smitt JH (1998) The millennium criteria for the diagnosis of atopic dermatitis. Exp Dermatol 7:132–138

    Article  PubMed  CAS  Google Scholar 

  • Campbell JJ, Haraldsen G, Pan J, Rottman J, Qin S, et al (1999) The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 400:776–780

    Article  PubMed  CAS  Google Scholar 

  • Catalina MD, Estess P, Siegelman MH (1999) Selective requirements for leukocyte adhesion molecules in models of acute and chronic cutaneous inflammation: participation of E- and P- but not L-selectin. Blood 93:580–589

    PubMed  CAS  Google Scholar 

  • Cooper KD, Voorhees JJ, Fisher GJ, Chan LS, Gupta AK, Baadsgaard O (1990) Effects of cyclosporine on immunologic mechanisms in psoriasis. J Am Acad Dermatol 23:1318–26; discussion 26–28

    Article  PubMed  CAS  Google Scholar 

  • Dieu MC, Vanbervliet B, Vicari A, Bridon JM, Oldham E, et al (1998) Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med 188:373–386

    Article  PubMed  CAS  Google Scholar 

  • Dieu-Nosjean MC, Massacrier C, Homey B, Vanbervliet B, Pin JJ, et al (2000) Macrophage inflammatory protein 3a is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J Exp Med 192:705–718

    Article  PubMed  CAS  Google Scholar 

  • Elder JT, Nair RP, Voorhees JJ (1994) Epidemiology and the genetics of psoriasis. J Invest Dermatol 102:24S–27S

    Article  PubMed  CAS  Google Scholar 

  • Ellis CN, Gorsulowsky DC, Hamilton TA, Billings JK, Brown MD, et al (1986) Cyclosporine improves psoriasis in a double-blind study. JAMA 256:3110–3116

    Article  PubMed  CAS  Google Scholar 

  • Ellis CN, Krueger GG (2001) Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med 345:248–255

    Article  PubMed  CAS  Google Scholar 

  • Flier J, Boorsma DM, van Beek PJ, Nieboer C, Stoof TJ, et al (2001) Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL 11 in different types of skin inflammation. J Pathol 194:398–405

    Article  PubMed  CAS  Google Scholar 

  • Fraticelli P, Sironi M, Bianchi G, D’Ambrosio D, Albanesi C, et al (2001) Fractalkine (CX3CL1) as an amplification circuit of polarized Thl responses. J Clin Invest 107:1173–1181

    Article  PubMed  CAS  Google Scholar 

  • Gillitzer R, Ritter U, Spandau U, Goebeler M, Brocker EB (1996) Differential expression of GRO-a and IL-8 mRNA in psoriasis: a model for neutrophil migration and accumulation in vivo. J Invest Dermatol 107:778–782

    Article  PubMed  CAS  Google Scholar 

  • Giustizieri ML, Mascia F, Frezzolini A, De Pita O, Chinni LM, et al (2001) Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell-derived cytokines. J Allergy Clin Immunol 107:871–877

    Article  PubMed  CAS  Google Scholar 

  • Gottlieb AB, Masud S, Ramamurthi R, Abdulghani A, Romano P, et al (2003) Pharmacodynamic and pharmacokinetic response to anti-tumor necrosis factor-a monoclonal antibody (infliximab) treatment of moderate to severe psoriasis vulgaris. J Am Acad Dermatol 48:68–75

    Article  PubMed  Google Scholar 

  • Grewe M, Bruijnzeel-Koomen CA, Schopf E, Thepen T, Langeveld-Wildschut AG, et al (1998) A role for Th 1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today 19:359–361

    Article  PubMed  CAS  Google Scholar 

  • Grewe M, Gyufko K, Schopf E, Krutmann J (1994) Lesional expression of interferon-gamma in atopic eczema. Lancet 343:25–26

    Article  PubMed  CAS  Google Scholar 

  • Grewe M, Walther S, Gyufko K, Czech W, Schopf E, Krutmann J (1995) Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients. J Invest Dermatol 105:407–410

    Article  PubMed  CAS  Google Scholar 

  • Groves RW, Allen MH, Barker JN, Haskard DO, MacDonald DM (1991) Endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in cutaneous inflammation. Br J Dermatol 124:117–123

    Article  PubMed  CAS  Google Scholar 

  • Hatano Y, Katagiri K, Takayasu S (1999) Increased levels in vivo of mRNAs for IL-8 and macrophage inflammatory protein- l a(MIP-1 a), but not of RANTES mRNA in peripheral blood mononuclear cells of patients with atopic dermatitis (AD). Clin Exp Immunol 117:237–243

    Article  PubMed  CAS  Google Scholar 

  • Homey B, Alenius H, Muller A, Soto H, Bowman EP, et al (2002) CCL27CCR 1 o interactions regulate T cell-mediated skin inflammation. Nat Med 8:157–165

    Article  PubMed  CAS  Google Scholar 

  • Homey B, Dieu-Nosjean MC, Wiesenborn A, Massacrier C, Pin JJ, et al (2000 a) Up-regulation of macrophage inflammatory protein-3a/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 164:6621–6632

    Google Scholar 

  • Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, et al (2000b) Cutting edge: the orphan chemokine receptor G protein-coupled receptor2(GPR-2, CCR 10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J Immunol 164:3465–3470

    PubMed  CAS  Google Scholar 

  • Horikawa T, Nakayama T, Hikita I, Yamada H, Fujisawa R, et al (2002) IFN-gamma-inducible expression of thymus and activation-regulated chemokine/CCL 17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and their roles in atopic dermatitis. Int Immunol 14:767–773

    Article  PubMed  CAS  Google Scholar 

  • Kaburagi Y, Shimada Y, Nagaoka T, Hasegawa M, Takehara K, Sato S (2001) Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-1 a, MIP- lβ, and eotaxin) in patients with atopic dermatitis. Arch Dermatol Res 293:350–355

    Article  PubMed  CAS  Google Scholar 

  • Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, et al (2003) Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris. J Allergy Clin Immunol 111:592–597

    Article  PubMed  CAS  Google Scholar 

  • Kinney T, Rawlins M, Kozarek R, France R, Patterson D (2003) Immunomodulators and “on demand” therapy with infliximab in Crohn’s disease: clinical experience with 400 infusions. Am J Gastroenterol 98:608–612

    PubMed  CAS  Google Scholar 

  • Kulke R, Bornscheuer E, Schluter C, Bartels J, Rowert J, et al (1998) The CXC receptor 2 is overexpressed in psoriatic epidermis. J Invest Dermatol 110:90–94

    Article  PubMed  CAS  Google Scholar 

  • Leung DY, Bieber T (2003) Atopic dermatitis. Lancet 361:151–160

    Article  PubMed  Google Scholar 

  • Liao F, Rabin RL, Smith CS, Sharma G, Nutman TB, Farber JM (1999) CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3a. J Immunol 162:186–194

    PubMed  CAS  Google Scholar 

  • Middleton J, Neil S, Wintle J, Clark-Lewis I, Moore H, et al (1997) Transcytosis and surface presentation of IL-8 by venular endothelial cells. Cell 91:385–395

    Article  PubMed  CAS  Google Scholar 

  • Morales J, Homey B, Vicari AP, Hudak S, Oldham E, et al (1999) CTACK, a skin-associated chemokine that preferentially attracts skin- homing memory T cells. Proc Natl Acad Sci U S A 96:14470–14475

    Article  Google Scholar 

  • Morita E, Kameyoshi Y, Hiragun T, Mihara S, Yamamoto S (2001) The C-C chemokines, RANTES and eotaxin, in atopic dermatitis. Allergy 56:194–195

    Article  PubMed  CAS  Google Scholar 

  • Muller A, Homey B, Soto H, Ge N, Catron D, et al (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410:50–56

    Article  PubMed  CAS  Google Scholar 

  • Nakayama T, Fujisawa R, Yamada H, Horikawa T, Kawasaki H, et al (2001) Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3a/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int Immunol 13:95–103

    Article  PubMed  CAS  Google Scholar 

  • Nickoloff BJ, Wrone-Smith T (1999) Injection of pre-psoriatic skin with CD4<sup>+</sup> T cells induces psoriasis. Am J Pathol 155:145–158

    Article  PubMed  CAS  Google Scholar 

  • Okazaki H, Kakurai M, Hirata D, Sato H, Kamimura T, et al (2002) Characterization of chemokine receptor expression and cytokine production in circulating CD4<sup>+</sup> T cells from patients with atopic dermatitis: up-regulation of C-C chemokine receptor 4 in atopic dermatitis. Clin Exp Allergy 32:1236–1242

    Article  PubMed  CAS  Google Scholar 

  • Ong PY, Leung DY (2002) The chemokine receptor CCR6 identifies interferon-gamma expressing T cells and is decreased in atopic dermatitis as compared with psoriasis. J Invest Dermatol 119:1463–1464

    Article  PubMed  CAS  Google Scholar 

  • Ortonne JP (1996) Aetiology and pathogenesis of psoriasis. Br J Dermatol 135 Suppl 49:1–5

    Article  PubMed  Google Scholar 

  • Picker LJ (1993) Regulation of tissue-selective T lymphocyte homing receptors during the virgin to memory/effector cell transition in human secondary lymphoid tissues. Am Rev Respir Dis 148:S47—S54

    Article  PubMed  Google Scholar 

  • Picker LJ, Martin RJ, Trumble A, Newman LS, Collins PA, et al (1994) Differential expression of lymphocyte homing receptors by human memory/ effector T cells in pulmonary versus cutaneous immune effector sites. Eur J Immunol 24:1269–1277

    Article  PubMed  CAS  Google Scholar 

  • Picker LJ, Terstappen LW, Rott LS, Streeter PR, Stein H, Butcher EC (1990) Differential expression of homing-associated adhesion molecules by T cell subsets in man. J Immunol 145:3247–3255

    PubMed  CAS  Google Scholar 

  • Picker LJ, Treer JR, Ferguson-Darnell B, Collins PA, Bergstresser PR, Terstappen LW (1993) Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells. J Immunol 150:1122–1136

    PubMed  CAS  Google Scholar 

  • Rau R (2002) Adalimumab (a fully human anti-tumour necrosis factor a monoclonal antibody) in the treatment of active rheumatoid arthritis:the initial results of five trials. Ann Rheum Dis 61:ii70–73

    PubMed  CAS  Google Scholar 

  • Raychaudhuri SP, Jiang WY, Farber EM (2001) Cellular localization of fractalkine at sites of inflammation: antigen-presenting cells in psoriasis express high levels of fractalkine. Br J Dermatol 144:1105–1113

    Article  PubMed  CAS  Google Scholar 

  • Raychaudhuri SP, Jiang WY, Farber EM, Schall TJ, Ruff MR, Pert CB (1999) Upregulation of RANTES in psoriatic keratinocytes: a possible pathogenic mechanism for psoriasis. Acta Derm Venereol 79:9–11

    Article  PubMed  CAS  Google Scholar 

  • Reiss Y, Proudfoot AE, Power CA, Campbell JJ, Butcher EC (2001) CC chemokine receptor (CCR)4 and the CCR 10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J Exp Med 194:1541–1547

    Article  PubMed  CAS  Google Scholar 

  • Rot A (1992) Binding of neutrophil attractant/activation protein-1 (interleukin 8) to resident dermal cells. Cytokine 4:347–352

    Article  PubMed  CAS  Google Scholar 

  • Rottman JB, Smith TL, Ganley KG, Kikuchi T, Krueger JG (2001) Potential role of the chemokine receptors CXCR3, CCR4, and the integrin aEβ<sup>-</sup>I in the pathogenesis of psoriasis vulgaris. Lab Invest 81:335–347

    Article  PubMed  CAS  Google Scholar 

  • Ruzicka T, Bieber T, Schopf E, Rubins A, Dobozy A, et al (1997) A shortterm trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. N Engl J Med 337:816–821

    Article  PubMed  CAS  Google Scholar 

  • Santamaria LF, Perez Soler MT, Hauser C, Blaser K (1995) Allergen specificity and endothelial transmigration of T cells in allergic contact dermatitis and atopic dermatitis are associated with the cutaneous lymphocyte antigen. Int Arch Allergy Immunol 107:359–362

    Article  PubMed  CAS  Google Scholar 

  • Santamaria Babi LF, Moser R, Perez Soler MT, Picker LJ, Blaser K, Hauser C (1995 a) Migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4), and the lymphocyte function-associated antigen-1 (LFA-1). J Immunol 154:1543–1550

    PubMed  CAS  Google Scholar 

  • Santamaria Babi LF, Picker LJ, Perez Soler MT, Drzimalla K, Flohr P, et al (1995 b) Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen. J Exp Med 181:1935–1940

    Article  PubMed  CAS  Google Scholar 

  • Schon MP (1999) Animal models of psoriasis –what can we learn from them? J Invest Dermatol 112:405–410

    Article  PubMed  CAS  Google Scholar 

  • Schon MP, Detmar M, Parker CM (1997) Murine psoriasis-like disorder induced by naive CD4<sup>+</sup> T cells. Nat Med 3:183–188

    Article  PubMed  CAS  Google Scholar 

  • Stingl G (2001) IgE-mediated, Fc (epsilon) RI-dependent allergen presentation: a pathogenetic factor in atopic dermatitis? J Am Acad Dermatol 45: S 17–S 20

    Article  CAS  Google Scholar 

  • Taha RA, Minshall EM, Leung DY, Boguniewicz M, Luster A, et al (2000) Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis. J Allergy Clin Immunol 105:1002–1007

    Article  PubMed  CAS  Google Scholar 

  • Uchida T, Suto H, Ra C, Ogawa H, Kobata T, Okumura K (2002) Preferential expression of T(h)2-type chemokine and its receptor in atopic dermatitis. Int Immunol 14:1431–1438

    Article  PubMed  CAS  Google Scholar 

  • Wakugawa M, Nakamura K, Akatsuka M, Kim SS, Yamada Y, et al (2001) Expression of CC chemokine receptor 3 on human keratinocytes in vivo and in vitro –upregulation by RANTES. J Dermatol Sci 25:229–235

    Article  PubMed  CAS  Google Scholar 

  • Werfel T, Morita A, Grewe M, Renz H, Wahn U, et al (1996) Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. J Invest Dermatol 107:871–876

    Article  PubMed  CAS  Google Scholar 

  • Wrone-Smith T, Nickoloff BJ (1996) Dermal injection of immunocytes induces psoriasis [see comments]. J Clin Invest 98:1878–1887

    Article  PubMed  CAS  Google Scholar 

  • Yamashita T, Akamatsu H, Tomitaka A, Ogawa Y, Sugawara N, Matsunaga K (2003) IP-10 in atopic dermatitis. Allergy 58:261

    Article  PubMed  CAS  Google Scholar 

  • Yamashita U, Kuroda E (2002) Regulation of macrophage-derived chemokine (MDC, CCL22) production. Crit Rev Immunol 22:105–114

    Article  PubMed  CAS  Google Scholar 

  • Yawalkar N, Uguccioni M, Scharer J, Braunwalder J, Karlen S, et al (1999) Enhanced expression of eotaxin and CCR3 in atopic dermatitis. J Invest Dermatol 113:43–48

    Article  PubMed  CAS  Google Scholar 

  • Ying S, Robinson DS, Meng Q, Barata LT, McEuen AR, et al (1999) C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). J Immunol 163:3976–3984

    PubMed  CAS  Google Scholar 

  • Ying S, Taborda-Barata L, Meng Q, Humbert M, Kay AB (1995) The kinetics of allergen-induced transcription of messenger RNA for monocyte chemotactic protein-3 and RANTES in the skin of human atopic subjects: relationship to eosinophil, T cell, and macrophage recruitment. J Exp Med 181:2153–2159

    Article  PubMed  CAS  Google Scholar 

  • Zheng X, Nakamura K, Furukawa H, Nishibu A, Takahashi M, et al (2003) Demonstration of TARC and CCR4 mRNA expression and distribution using in situ RT PCR in the lesional skin of atopic dermatitis. J Dermatol 30:26–32

    PubMed  CAS  Google Scholar 

  • Zlotnik A, Yoshie O (2000) Chemokines: a new classification system and their role in immunity. Immunity 12:121–7

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. B. Homey
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Bünemann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Immunology, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA, 94804, USA

    R. Horuk

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Homey, B., Bünemann, E. (2004). Chemokines and Inflammatory Skin Diseases. In: Murphy, P.M., Horuk, R. (eds) Chemokine Roles in Immunoregulation and Disease. Ernst Schering Research Foundation Workshop, vol 45. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05403-1_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-05403-1_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05405-5

  • Online ISBN: 978-3-662-05403-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation