Chemokines and Inflammatory Skin Diseases
Accumulating evidence indicates that chronically relapsing inflammatory skin diseases such as atopic dermatitis and psoriasis are T cell-mediated diseases. Thus, understanding the underlying mechanisms of memory T cell homing to the skin may provide promising targets for the development of novel therapeutics to interfere with inflammatory processes of the skin. Chemokines, a superfamily of small cytokine-like, chemotactic proteins, have recently been shown to critically regulate leukocyte trafficking. Here we summarize results of recent studies associating chemokines with a psoriatic or atopic dermatitis phenotype and delineating their role in the recruitment of memory T cells to the skin.
KeywordsNickel Migration Arthritis Dust Filtration
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