The Role of Chemokines in Inflammatory Skin Diseases

  • G. Girolomoni
  • S. Pastore
  • A. Cavani
  • C. Albanesi
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 44)

Abstract

The skin provides a major boundary between the host and the external environment, and it is obviously very well equipped to mount effective immune responses against microorganisms. Dendritic cells (DCs), including epidermal Langerhans cells and dermal DCs, specialize in recognizing and capturing foreign antigens as well as in the activation of naive T cells, and are thus essential for the induction of immune responses. T lymphocytes transduce antigen recognition into effector mechanisms to eliminate pathogens. The recruitment of T cells and other leukocytes at the site of skin inflammation is therefore a critical step for an efficient engagement of potentially dangerous signals (Koelle et al. 2002). The outcome of T cell-dependent skin reactions also depends on the cross-talk between infiltrating T cells and resident skin populations. Keratinocytes, mast cells, and endothelial cells, which constitute the static component of the skin immune system, as well as DCs contribute to attract discrete T cell subsets in the skin. In turn, activated T cells secrete cytokines and express molecules which activate resident cells, leading to amplification of the inflammatory reaction.

Keywords

Nickel Pancreatitis Interferon Manes Integrin 

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© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • G. Girolomoni
  • S. Pastore
  • A. Cavani
  • C. Albanesi

There are no affiliations available

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