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Biological Effects of ERα-and ERβ-Selective Estrogens

  • Conference paper
New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 46))

Abstract

Estrogens control a diversity of physiological functions in different tissues. In mammals, the organs of the female reproductive tract including the uterus, the vagina, the ovary (Jennings and Creasman 1997), the mammary gland (Lippman and Dickson 1987; Dickson and Lippman 1989; Prichard 1997; Satyaswaroop 1997), the pituitary, and the hypothalamus are major targets of estrogens. However, estrogens also influence nonreproductive organs and systems. In the liver, estrogens cause alterations in the production of plasmatic proteins and in lipid metabolism (Krattenmacher et al. 1994; Von Schoultz et al. 1989; Steingold et al. 1991). In addition, evidence has been accumulated within the last two decades demonstrating that estrogens exhibit an important regulatory impact on the bone (Turner 1997), the urogenital tract (Kelleher 1997), the cardiovascular system (Nathan and Chaudhuri 1997; Clarkson and Anthony 1997; Lobo 1990; Sarrel 1992; Foegh 1992), and on brain functions (McEwen et al. 1997; Halbreich 1997; Sherwin 1997 a,b; Henderson 1997; Birge 1997).

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Authors
  1. K.-H. Fritzemeier
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  2. A. Hillisch
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  3. W. Elger
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  4. U. Kaufmann
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  7. B. Lindenthal
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Editor information

K. S. Korach A. Hillisch K. H. Fritzemeier

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© 2004 Springer-Verlag Berlin Heidelberg

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Fritzemeier, KH. et al. (2004). Biological Effects of ERα-and ERβ-Selective Estrogens. In: Korach, K.S., Hillisch, A., Fritzemeier, K.H. (eds) New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy. Ernst Schering Research Foundation Workshop, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05386-7_9

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  • DOI: https://doi.org/10.1007/978-3-662-05386-7_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05388-1

  • Online ISBN: 978-3-662-05386-7

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