Proteomics: high throughput protein functional analysis

Abstract

Currently, there is a major effort, on a genome-wide scale, to map protein-drug interactions and to discover drug targets (Sect. 9.1), to map protein-protein interactions (Sect. 9.2), to discover chemical activity of proteins (Sect. 9.3), and to resolve protein structures (Sect. 9.5). This effort, called proteomics, provides significant knowledge of the biology of organisms far beyond the level of sequence information (see, e.g., Adam et al., 2002b; Burbaum and Tobal; Edwards et al., 2000, 2002; Christendat et al., 2000; Figeys, 2002a, 2002c; Gallardo et al., 2002; Hubbard, 2002; Kersten et al., 2002; Koshland and Hamadani, 2002; Lin and Cornish, 2002; Liu et al., 2002; Morrison et al., 2002; Natsume et al., 2002; Yarmush and Jayaraman). The system-wide study of proteins and as well nonproteinaceous interaction partners largely employs protein microarray technology (see, e.g., MacBeath, 2002; Gera et al., 2002; Kukar et al., 2002; Talapatra et al., 2002) and bioinformatic methods (see, e.g., Bork, 2002).