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Lentivirus: A Vector for Nervous System Applications

  • Conference paper
Human Gene Therapy: Current Opportunities and Future Trends

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 43))

Abstract

Vectors based on lentiviruses are opening up new approaches for the treatment of neurological disease and damage. They efficiently deliver genes into many different types of primary neurons from a broad range of species including human, and the resulting gene expression is longterm and non-toxic. Numerous animal studies have now been undertaken with these vectors, and correction of disease models has been obtained. These vectors have been refined to a very high level, and they are now ready for clinical evaluation (reviewed in Martin-Rendon et al. 2001; Deglon and Aebischer 2002). This review will describe the general features of lentiviral vectors with particular emphasis on vectors derived from the non-primate lentivirus, equine infectious anaemia virus (EIAV), then give some key examples of gene transfer and genetic correction in animal models of neurological diseases. The prospects for the clinical evaluation of lentiviral vectors for the treatment of human neurological disease will be outlined.

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Authors
  1. S. M. Kingsman
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Editors and Affiliations

  1. Berlex Biosciences, 2600 Hilltop Drive, 94806, Richmond, CA, USA

    Gabor M. Rubanyi

  2. Department of Molecular Medicine, A.I. Virtanen Institute, University of Kuopio, P.O. Box 1627, 70211, Finland

    Seppo Ylä-Herttuala

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© 2003 Springer-Verlag Berlin Heidelberg

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Kingsman, S.M. (2003). Lentivirus: A Vector for Nervous System Applications. In: Rubanyi, G.M., Ylä-Herttuala, S. (eds) Human Gene Therapy: Current Opportunities and Future Trends. Ernst Schering Research Foundation Workshop, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05352-2_11

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  • DOI: https://doi.org/10.1007/978-3-662-05352-2_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05354-6

  • Online ISBN: 978-3-662-05352-2

  • eBook Packages: Springer Book Archive

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