Lentivirus: A Vector for Nervous System Applications
Vectors based on lentiviruses are opening up new approaches for the treatment of neurological disease and damage. They efficiently deliver genes into many different types of primary neurons from a broad range of species including human, and the resulting gene expression is longterm and non-toxic. Numerous animal studies have now been undertaken with these vectors, and correction of disease models has been obtained. These vectors have been refined to a very high level, and they are now ready for clinical evaluation (reviewed in Martin-Rendon et al. 2001; Deglon and Aebischer 2002). This review will describe the general features of lentiviral vectors with particular emphasis on vectors derived from the non-primate lentivirus, equine infectious anaemia virus (EIAV), then give some key examples of gene transfer and genetic correction in animal models of neurological diseases. The prospects for the clinical evaluation of lentiviral vectors for the treatment of human neurological disease will be outlined.
KeywordsHepatitis Convection Lymphoma Codon Recombination
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