Corey-Fuchs reaction

  • Jie Jack Li


One-carbon homologation of aldehyde to dibromoolefin, which is then treated with n-BuLi to produce a terminal alkyne.


Aldehyde Alkyne 


  1. 1.
    Corey, E. J.; Fuchs, P. L. Tetrahedron Lett. 1972, 3769.Google Scholar
  2. 2.
    For the synthesis of 1-bromalkynes, see, Grandjean, D.; Pale, P.; Chuche, J. Tetrahedron Len. 1994, 35, 3529.Google Scholar
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    Gilbert, A. M.; Miller, R.; Wulff, W. D. Tetrahedron 1999, 55, 1607.CrossRefGoogle Scholar
  4. 4.
    Muller, T. J. J. Tetrahedron Leu. 1999, 40, 6563.CrossRefGoogle Scholar
  5. 5.
    Senat, X.; Cabarrocas, G.; Rafel, S.; Ventura, M.; Linden, A.; Villalgordo, J. M. Tetrahedron: Asymmetry 1999, 10, 3417.CrossRefGoogle Scholar
  6. 6.
    Okamura, W. H.; Zhu, G.-D.; Hill, D. K.; Thomas, R. J.; Ringe, K.; Borchardt, D. B.; Norman, A. W.; Mueller, L. J. J. Org . Chem. 2002, 67, 1637.CrossRefGoogle Scholar
  7. 7.
    Falomir, E.; Murga, J.; Carda, M.; Marco, J. A. Tetrahedron Leu. 2003 44539. Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

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