Corey-Fuchs reaction

  • Jie Jack Li


One-carbon homologation of aldehyde to dibromoolefin, which is then treated with n-BuLi to produce a terminal alkyne.


Inorganic Chemistry Organic Chemistry Terminal Alkyne 
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    Corey, E. J.; Fuchs, P. L. Tetrahedron Lett. 1972, 3769.Google Scholar
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    For the synthesis of 1-bromalkynes, see, Grandjean, D.; Pale, P.; Chuche, J. Tetrahedron Len. 1994, 35, 3529.Google Scholar
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    Muller, T. J. J. Tetrahedron Leu. 1999, 40, 6563.CrossRefGoogle Scholar
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    Senat, X.; Cabarrocas, G.; Rafel, S.; Ventura, M.; Linden, A.; Villalgordo, J. M. Tetrahedron: Asymmetry 1999, 10, 3417.CrossRefGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

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