Corey-Fuchs reaction

  • Jie Jack Li

Abstract

One-carbon homologation of aldehyde to dibromoolefin, which is then treated with n-BuLi to produce a terminal alkyne.

Keywords

Aldehyde Alkyne 

References

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    Corey, E. J.; Fuchs, P. L. Tetrahedron Lett. 1972, 3769.Google Scholar
  2. 2.
    For the synthesis of 1-bromalkynes, see, Grandjean, D.; Pale, P.; Chuche, J. Tetrahedron Len. 1994, 35, 3529.Google Scholar
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    Falomir, E.; Murga, J.; Carda, M.; Marco, J. A. Tetrahedron Leu. 2003 44539. Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

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