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Corey-Fuchs reaction

  • Jie Jack Li

Abstract

One-carbon homologation of aldehyde to dibromoolefin, which is then treated with n-BuLi to produce a terminal alkyne.

Keywords

Inorganic Chemistry Organic Chemistry Terminal Alkyne 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Corey, E. J.; Fuchs, P. L. Tetrahedron Lett. 1972, 3769.Google Scholar
  2. 2.
    For the synthesis of 1-bromalkynes, see, Grandjean, D.; Pale, P.; Chuche, J. Tetrahedron Len. 1994, 35, 3529.Google Scholar
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    Gilbert, A. M.; Miller, R.; Wulff, W. D. Tetrahedron 1999, 55, 1607.CrossRefGoogle Scholar
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    Muller, T. J. J. Tetrahedron Leu. 1999, 40, 6563.CrossRefGoogle Scholar
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    Senat, X.; Cabarrocas, G.; Rafel, S.; Ventura, M.; Linden, A.; Villalgordo, J. M. Tetrahedron: Asymmetry 1999, 10, 3417.CrossRefGoogle Scholar
  6. 6.
    Okamura, W. H.; Zhu, G.-D.; Hill, D. K.; Thomas, R. J.; Ringe, K.; Borchardt, D. B.; Norman, A. W.; Mueller, L. J. J. Org . Chem. 2002, 67, 1637.CrossRefGoogle Scholar
  7. 7.
    Falomir, E.; Murga, J.; Carda, M.; Marco, J. A. Tetrahedron Leu. 2003 44539. Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

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