Clarke-Eschweiler reductive alkylation of amines

  • Jie Jack Li


Reductive methylation of primary or secondary amines using formaldehyde and formic acid.


Inorganic Chemistry Organic Chemistry Formic Acid Secondary Amine Hydrogen Source 
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  1. 1.
    Eschweiler, W. Chem. Ber. 1905, 38, 880.CrossRefGoogle Scholar
  2. 2.
    Clarke, H. T. J. Am. Chem. Soc. 1933, 55, 4571.CrossRefGoogle Scholar
  3. 3.
    Moore, M. L. Org. React. 1949, 5, 301. (Review).Google Scholar
  4. 4.
    Pine, S. H.; Sanchez, B. L. J. Org. Chem. 1971, 36, 829.Google Scholar
  5. 5.
    Bobowski, G. J. Org. Chem. 1985, 50, 929.Google Scholar
  6. 6.
    Alder, R. W.; Colclough, D.; Mowlam, R. W. Tetrahedron Lett. 1991, 32, 7755.CrossRefGoogle Scholar
  7. 7.
    Fache, F.; Jacquot, L.; Lemaire, M. Tetrahedron Lett. 1994, 35, 3313.CrossRefGoogle Scholar
  8. 8.
    Bulman P., Philip C.; Heaney, H.; Rassias, G. A.; Reignier, S.; Sampler, E. P.; Talib, S. Synlett 2000, 104.Google Scholar
  9. 9.
    Torchy, S.; Barbry, D. J. Chem. Soc. (C) 2001, 292.Google Scholar
  10. Rosenau, T.; Potthast, A.; Rohrling, J.; Hofinger, A.; Sixta, H.; Kosma, P. Synth. Commun. 2002, 32, 457.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

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