Name Reactions pp 428-428 | Cite as

Weinreb amide

  • Jie Jack Li


N-Methoxy-N-methyl-amide. Due to the chelation effect, nucleophilic addition of an organometallic reagent adds only once to give ketone, whereas normal amides would have led to double addition to afford tertiary alcohol.


Inorganic Chemistry Organic Chemistry Nucleophilic Addition Tertiary Alcohol Chelation Effect 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

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