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Weinreb amide

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Name Reactions
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Abstract

N-Methoxy-N-methyl-amide. Due to the chelation effect, nucleophilic addition of an organometallic reagent adds only once to give ketone, whereas normal amides would have led to double addition to afford tertiary alcohol.

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© 2003 Springer-Verlag Berlin Heidelberg

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Li, J.J. (2003). Weinreb amide. In: Name Reactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05336-2_313

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  • DOI: https://doi.org/10.1007/978-3-662-05336-2_313

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05338-6

  • Online ISBN: 978-3-662-05336-2

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