Name Reactions pp 428-428 | Cite as

Weinreb amide

  • Jie Jack Li

Abstract

N-Methoxy-N-methyl-amide. Due to the chelation effect, nucleophilic addition of an organometallic reagent adds only once to give ketone, whereas normal amides would have led to double addition to afford tertiary alcohol.

Keywords

Amide Ketone Prep 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

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