Name Reactions pp 175-176 | Cite as

Haworth reaction

  • Jie Jack Li

Abstract

Friedel-Crafts reaction of an arene with succinic anhydride is followed by reduction and an additional intramolecular Friedel-Crafts reaction to give tetralone. The entire process is called the Haworth reaction.

Keywords

Mane Anhydride Auger Tetralone 

References

  1. 1.
    Haworth, R. D. J. Chem. Soc. 1932, 1125.Google Scholar
  2. 2.
    Agranat, I.; Shih, Y. J. Chem. Educ. 1976, 53. 488.Google Scholar
  3. 3.
    Silveira, A., Jr.; McWhorter, E. J. J. Org. Chem. 1972, 37. 3687.Google Scholar
  4. 4.
    Aichaoui, H.; Poupaert, J. H.; Lesieur, D.; Henichart, J. P. Bull. Soc. Chim. Belg. 1992, 101. 1053.CrossRefGoogle Scholar
  5. 5.
    Auger, P.; Malaiyandi, M.; Wightman, R. H.; Williams, D. T. J. Labeled. Compd. Radiopharm. 1993, 33, 263.Google Scholar
  6. 6.
    Wipf, P.; Jung, J.-K. J. Org. Chem. 2000, 65, 6319.Google Scholar
  7. 7.
    Kadam, A. J.; Baraskar, U. K.; Mane, R. B. Indian J. Chem., Sect. B 2000, 39B, 822.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

Personalised recommendations