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Chemical Genomics of Orphan Nuclear Receptors

  • Conference paper
Small Molecule — Protein Interactions

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 42))

Abstract

The steroid hormone, thyroid hormone, retinoic acid, and vitamin D receptors are members of a family of ligand-activated transcription factors (Mangelsdorf et al. 1995). These nuclear hormone receptors contain two signature domains, a central double zinc finger DNA-binding domain (DBD) and a C-terminal ligand-binding domain (LBD) (Fig. 1). Sequence homology within these domains has allowed investigators to clone many additional members of the gene family. It is now known that there are a total of 48 nuclear receptors within the human genome (Maglich et al. 2001). The majority of these transcription factors are designated orphan receptors since they do not bind to the classical endocrine hormones. Characterization of the biological function of the orphan nuclear receptors has become an important endeavor of biomedical research, since each of them has the potential to be the regulator of a new hormone signaling pathway (Giguere 1999).

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Authors
  1. T. Willson
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Editors and Affiliations

  1. Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Straße 11, 44221, Dortmund, Germany

    H. Waldmann

  2. Universität Dortmund, Fachbereich 3, Organische Chemie, 44221, Dortmund, Germany

    H. Waldmann

  3. Medicinal Chemistry, Schering AG, 13342, Berlin, Germany

    M. Koppitz

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© 2003 Springer-Verlag Berlin Heidelberg

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Willson, T. (2003). Chemical Genomics of Orphan Nuclear Receptors. In: Waldmann, H., Koppitz, M. (eds) Small Molecule — Protein Interactions. Ernst Schering Research Foundation Workshop, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05314-0_4

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  • DOI: https://doi.org/10.1007/978-3-662-05314-0_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05316-4

  • Online ISBN: 978-3-662-05314-0

  • eBook Packages: Springer Book Archive

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