Drug Discovery at Signaling Interfaces
Protein-protein interfaces remain among the most challenging if not intractable targets for small-molecule drug discovery. Despite the wealth of structural information that has accumulated about these complexes and their tremendous value as biotherapeutics, little progress has been made toward identifying small molecules that can specifically target these interfaces. Here, I will review some of the progress we have made in targeting the cytokine receptor interfaces for drug discovery.
KeywordsDrug Discovery Signaling Interface Small Molecule Binding Rational Design Method Small Molecule Binding Site
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