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Drug Discovery at Signaling Interfaces

  • J. Wells
  • M. Arkin
  • A. Braisted
  • W. DeLano
  • B. McDowell
  • J. Oslob
  • B. Raimundo
  • M. Randal
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 42)

Abstract

Protein-protein interfaces remain among the most challenging if not intractable targets for small-molecule drug discovery. Despite the wealth of structural information that has accumulated about these complexes and their tremendous value as biotherapeutics, little progress has been made toward identifying small molecules that can specifically target these interfaces. Here, I will review some of the progress we have made in targeting the cytokine receptor interfaces for drug discovery.

Keywords

Drug Discovery Signaling Interface Small Molecule Binding Rational Design Method Small Molecule Binding Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • J. Wells
  • M. Arkin
  • A. Braisted
  • W. DeLano
  • B. McDowell
  • J. Oslob
  • B. Raimundo
  • M. Randal

There are no affiliations available

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