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Electrochemical Sensors for the Detection of Superoxide and Nitric Oxide — Two Biologically Important Radicals

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Ultrathin Electrochemical Chemo- and Biosensors

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 2))

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Abstract

Electrodes are favourable sensing elements for the detection of the short-lived species nitric oxide and superoxide in the medical field. They can provide access to a time-and spatially resolved analysis allowing a deeper insight into the physiological role and interaction of both radicals. Superoxide sensing uses mainly electrodes modified with cytochrome c or superoxide dismutase as recognition elements. Operation is based on direct protein electrochemistry or on the detection of superoxide decomposition products. For NO quantification mainly electrodes modified with gas-permeable membranes have been developed. Transition metal complexes have been applied for the enhancement of NO electrocatalysis lowering the applied electrode potential. More recently haem proteins have also been combined with electrodes. Based on direct protein-electrode contacts, NO sensing is feasible exploiting specific NO interaction with the haem group.

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  1. F. Lisdat
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  1. Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany

    Vladimir M. Mirsky

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Lisdat, F. (2004). Electrochemical Sensors for the Detection of Superoxide and Nitric Oxide — Two Biologically Important Radicals. In: Mirsky, V.M. (eds) Ultrathin Electrochemical Chemo- and Biosensors. Springer Series on Chemical Sensors and Biosensors, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05204-4_6

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