Skip to main content

Abstract

Experimental and clinical observations have demonstrated therapeutic effects of ionizing radiation on mature and proliferating vessels. On the basis of these results, it was thought that radiation therapy might well be helpful in neovascular late stages of age-related macular degeneration (AMD). The ocular tissues exhibit differing radiation effects, so that the high susceptibility of proliferating endothelial cells to radiation seemed to provide a scientific rationale for a new therapeutic approach to choroidal neovascularization (CNV).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alberti W (1986) Radiotherapy of choroidal hemangioma. Int J Radiat Oncol Biol Phys 12: 122

    Article  Google Scholar 

  • Appen RE, Bosch A (1983) Bilateral loss of vision following radiation therapy. Neuroophthalmology 3: 97

    Article  Google Scholar 

  • Archer DR, Amoaku WMK, Gardiner TA (1991) Radiation retinopathy–clinical, histopathological, ultrastructural and experimental correlations. Eye 5: 239–51

    Article  PubMed  Google Scholar 

  • Bergink GJ, Deutman AF, van den Brock JFCM, Daal WAJ, van der Maazen RWM (1994) Radiation therapy for subfoveal choroidal membranes in age-related macular degeneration.Graefe’s Arch Clin Exp Ophthalmol 232: 591–598

    Article  CAS  Google Scholar 

  • Bergink GJ, Deutman AF, Van den Broek JECM, Van Daal WAJ, van der Maazen RMW (1995) Radiation therapy for age-related subfoveal choroidal neovascular membranes. Doc Ophthalmol 90: 67–74

    Article  PubMed  CAS  Google Scholar 

  • Bergink GJ, Hoyong CB, van der Maazen RWM, Vingerling JR, van Daal WA, Deutman AF (1998) A randomized controlled clinical trial on the efficacy of radiation therapy in the control of subfoveal choroidal neovascularization in age-related macular degeneration: radiation versus observation. Graefes Arch Clin Exp Ophthalmol 236: 321–325

    Article  PubMed  CAS  Google Scholar 

  • Bessell AM, Henk JM, Whitelocke RA, Wright JE (1987) Ocular morbidity after radiation therapy of orbital and conjunctival lymphoma. Eye 1: 90–96

    Article  PubMed  Google Scholar 

  • Buys NS, KernsTC, Sanborn G (1957) Irradiation damage to the chiasm. Am J Ophthalmol 44: 483

    PubMed  CAS  Google Scholar 

  • Chakravarthy U, Biggart JH, Gardiner TA, Archer DB, Maguire CJF (1989) Focal irradiation of perforating eye injuries. Curr Eye Res 8: 1241–1250

    Article  PubMed  CAS  Google Scholar 

  • Chakravarthy U, Houston RF, Archer DB (1993) Treatment of age-related subfoveal neovascular membranes by teletherapy: a pilot study. Br J Ophthalmol 77: 265–273

    Article  PubMed  CAS  Google Scholar 

  • Chan RC, Shukovsky LJ (1976) Effects of irradiation on the eye. Radiology 120: 673–675

    PubMed  CAS  Google Scholar 

  • Char DH, Irvine Al, Posner MD, Quivey J, Philips TL, Kroll S (1999) Randomized trial of radiation for age-related macular degeneration. Am J Ophthalmol 127: 574–578

    Article  PubMed  CAS  Google Scholar 

  • Ciulla TA, Danis RP, Klein SB, Malinosysky VE, Soni PS, Pratt LM, Pugh NO, Morphis JG, Bloch C, Cameron J (2002) Proton therapy for exsudative age-related macular degeneration: a randomized, sham-controlled trial. Am J Ophthalmol 134: 905–906

    Article  PubMed  Google Scholar 

  • De Gowin RL, Lewis JL, Hoak JC, Mueller AL, Gibson DP (1974) Radiosensitivity of human endothelial cells in culture. J Lab Clin Med 84: 42–48

    PubMed  Google Scholar 

  • Engenhart R, Wowra B, Debus J, Kimmig B, Höver KH, Lorenz WJ,Wannenmacher M (1994)The role of high dose single fraction irradiation in small and large intracranial arteriovenous malformations. Int J Radiat Oncol Biol Phys 30: 521–529

    Google Scholar 

  • Engenhart R,Wowra B,Kimmig B, Höver KH,Kunze S,Wannenmacher M (1992) Stereotaktische Konvergenzbestrahlung: Aktuelle Perspektiven auf der Grundlage klinischer Ergebnisse. Strahlenther Onkol 168: 245–259

    Google Scholar 

  • Eter N, Schuller H (2001) External beam radiotherapy for age-related macular degeneration causes transient objective changes in tear-fill function. Graefes Arch Clin Exp Ophthalmol 239: 923–926

    Article  PubMed  CAS  Google Scholar 

  • Eter N, Schuller H, Spitznas M (2001) Radiotherapy for age-related macular degeneration: is there a benefit for classic CNV? Int Ophthalmol 24: 13–19

    Article  PubMed  CAS  Google Scholar 

  • Finger PT, Balkin RA, Berson A, Sherr D, Bosworth JL (1995) Low-dose radiation therapy for subretinal neovascularization.Ophthalmology 102: 5–94

    Google Scholar 

  • Forrest APM, Brown DAP, Morris SR, Illingworth CW (1956) Pituitary radon implant for advanced cancer. Lancet 370: 399

    Article  Google Scholar 

  • Gripp S,Stammen J, Petersen C, Hartmann A,Willers R,Althaus C (2002) Radiotherapy in age-related macular degeneration.lnt J Radiation Oncology Biol Phys 52: 489–495

    Google Scholar 

  • Guyton JS, Reese AB (1948) Use of roentgen therapy for retinal diseases characterized by new-formed blood vessels. Arch Ophthalmol 40: 389

    Article  CAS  Google Scholar 

  • Haas A, Papaefthymiou G, Langmann G, Schrottner O, Feigl B, Leber KA, Hanselmayer R, Pendl G (2000) Gamma knife treatment of subfoveal, classic neovascularization in age-related macular degeneration: a pilot study. J Neurosurg 93: 172–176

    PubMed  Google Scholar 

  • Hart PM, Chakravarthy U, Mackenzie G, Chisholm IH, Bird AC, Stevenson MR, Owens SL, Hall V, Houston RF, McCulloch DW, Plowman N (2002) Visual outcomes in the subfoveal radiotherapy study: a randomized controlled trial of teletherapy for age-related macular degeneration. Arch Ophthalmol 120: 1029–1038

    Article  PubMed  CAS  Google Scholar 

  • Holz FG, Bellmann C, Engenhart R, Völcker HE (1996) External stereotactic focal irradiation therapy for subfoveal choroidal neovascularization. Invest Ophthalmol Vis Sci 37: 116

    Google Scholar 

  • Immonen I, Jaakkola A, Heikkonen J (1995) Treatment of subfoveal choroidal neovascular membranes using strontium plaque irradiation. Invest Ophthalmol Vis Sci 36: 224

    Google Scholar 

  • Jaakkola A, Tommila P, Laatikainen L, Immonen I (2001) Grading choroidal neovascular membrane regression after strontium plaque radiotherapy; masked subjective evaluation vs planimetry. Eur J Ophthalmol 11: 269–276

    PubMed  CAS  Google Scholar 

  • Johnson LK, Longenecker JP, Fajardo LF (1982) Differential radiation response of cultured endothelial cells and smooth myocytes. Anal Quant Cytol 4: 188–198

    PubMed  CAS  Google Scholar 

  • Joussen AM, Kruse FE, Oetzel D,Voelcker HE (2000) Irradiation for inhibition of endothelial cell growth in vitro. Ophthalmic Res 32: 222–228

    CAS  Google Scholar 

  • Karp LA, Streeten BW, Cogan DG (1979) Radiation-induced atrophy of the Meibomian glands. Arch Ophthalmol 97: 303–305

    Article  PubMed  CAS  Google Scholar 

  • Macfaul PA, Bedford MA (1970) Ocular complications after therapeutic irradiation. Br J Ophthalmol 54: 237–247

    Article  PubMed  CAS  Google Scholar 

  • Marcus DM, Shells W, Johnson MH, McIntosh SB, Leibach DB, Maguire A, Alexander J,Samy CN (2001) External beam irradiation of subfoveal choroidal neovascularization complicating age-related macular degeneration:one-year results of a prospective, double-masked, randomized clinical trial. Arch Ophthalmol 119: 171–180

    CAS  Google Scholar 

  • Matsuhashi H, Noda Y, Takahashi D, Mariya Y (2000) Radiation therapy for small choroidal neovascularizations in age-related macular degeneration.Jpn J Ophthalmol 44: 653–660

    CAS  Google Scholar 

  • Mendelsohn ME, Spaide RF, Abrahamson DH, Yannuzzi LA (1995) Radiation therapy for wet macular degeneration. Ophthalmology 102: 94

    Google Scholar 

  • Parsons JT, Bova FJ, Fitzgerald CR, Mendenhall WM, Million RR (1994) Radiation optic neuropathy after megavoltage external-beam irradiation: analysis of time-dose factors. Int J Oncol Biol Phys 30: 755–763

    Article  CAS  Google Scholar 

  • Parsons JT, Bova H, Fitzgerald CR, Mendenhall WM, Million RR (1994) Radiation retinopathy after external-beam irradiation: analysis of time-dose factors. Int J Oncol Biol Phys 30: 765–773

    Article  CAS  Google Scholar 

  • Parsons 1T, Fitzgerald CR, Hood CI, Ellingwood KE, Bova FJ, Million RR (1983) The effects of irradiation on the eye and optic nerve. Int J Radiat Oncol Biol Phys 9: 609–622

    Google Scholar 

  • Peterson IA, Kris JP, McDougall IR, Donaldson SS (1990) Prognostic factors in the radiotherapy of Graves’ ophthalmopathy. Int J Radiat Oncol Biol Phys 19: 259–264

    Article  Google Scholar 

  • Reinhold HS (1988) Vasculoconnective tissue. In: Scherer E, Streffer C,Trott KR (eds) Radiopathology of organs and tissues. Springer, Berlin Heidelberg New York, p 263

    Google Scholar 

  • Rubin E (1968) Radiotherapy of intraocular and orbital tumors.

    Google Scholar 

  • Schittkowski M, Schneider H, Gruschow K, Ziegler PG, Guthoff R, Fietkau R (2001) 3 years’ experience with low dosage fractionated percutaneous teletherapy in subfoveal neovascularization. Clinical results. Strahlenther Onkol 177: 345–353

    Google Scholar 

  • Scott TA, Augsburger JJ, Brady LW, Hernandez C, Woodliegh R (1991) Low-dose ocular irradiation for diffuse choroidal hemangiomas associated with bullous nonrhegmatogenous retinal detachment. Retina 11: 389–393

    PubMed  CAS  Google Scholar 

  • Spaide RF, Guyer DR, Mc Cormick B, Yannuzzi LA, Burke K, Mendelsohn M, Haas A, Slakter JS, Sorenson JA, Fisher YL, Abramson D (1998) External beam radiation therapy for choroidal neovascularization. Ophthalmology 105: 24–30

    Article  PubMed  CAS  Google Scholar 

  • Stallard HB (1933) Radiant energy as (a) a pathogenic and (b) a therapeutic agent in ophthalmic disorders. Br J Ophthalmol 6: 1

    Google Scholar 

  • Stalmans P, Leys A, Van Limbergen E (1997) External beam radiotherapy (20 Gy, 2 Gy fractions) fails to control the growth of choroidal neovascularizations in age-related macular degeneration: a review of 111 cases. Retina 17: 481–492

    PubMed  CAS  Google Scholar 

  • Sutter H, Utermann D (1973) Gesichtspunkte zur medikamentösen Behandlung der degenerativen “senilen”Maculaaffektionen. Ber Dtsch Ophthalmol Ges 573

    Google Scholar 

  • The Radiation Therapy for Age-related Macular Degeneration (RAD) Study Group (1999) A prospective randomized double-masked trial on radiation therapy or neovascular age-related macular degeneration (RAD Study). Ophthalomology 106: 2239–2247

    Google Scholar 

  • Valmaggia C, Ries G, Ballinari P (2002) Radiotherapy for subfoveal choroidal neovascularization in age-related macular degeneration: a randomized clinical trial. Am J Ophthalmol 133: 521–529

    Article  PubMed  Google Scholar 

  • Wilson WB, Perez GM, Kleinschmidt-Demasters BK (1987) Sudden onset of blindness in patients treated with oral CCNU and low-dose cranial irradiation. Cancer 59: 901–907

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schütt, F., Bellmann, C., Bindewald, A., Engenhart-Cabillic, R., Debus, J., Holz, F.G. (2004). Radiation Therapy. In: Age-related macular degeneration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05199-3_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-05199-3_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-05201-3

  • Online ISBN: 978-3-662-05199-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics