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Active and Passive Monovalent Ion Transport Association with Membrane Antigens in Sheep Red Cells: a Molecular Riddle

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Red Cell Membrane Transport in Health and Disease

Abstract

The occurrence in the animal kingdom of species (ruminants, canines) with red blood cells (RBCs) containing different concentrations of K+ and Na+ has fascinated a number of laboratories over the past century. One of the great discoveries in biology and physiology is the fact that active and passive cation transport necessary for the maintenance of the different cation steady states in ruminant RBCs is associated with membrane surface antigens through which the respective antibodies, by classic antigen/antibody reactions, modify transport. In particular, the sheep RBC system has served as a useful model to seek similar associations in other species, and in human pathophysiology, as reviewed earlier (Lauf 1975, 1978; Ellory and Tucker 1983; Dunham 1990).

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  1. Department of Physiology and Biophysics, Wright State University School of Medicine, Dayton, OH, 45435, USA

    Peter K. Lauf

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  1. Peter K. Lauf
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  1. Naturwissenschaftlich-Technische Fakultät III, Arbeitsgruppe Biophysik, Universität des Saarlandes, P.O.Box 151150, 66041, Saarbrücken, Germany

    Ingolf Bernhardt

  2. Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK

    J. Clive Ellory

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Lauf, P.K. (2003). Active and Passive Monovalent Ion Transport Association with Membrane Antigens in Sheep Red Cells: a Molecular Riddle. In: Bernhardt, I., Ellory, J.C. (eds) Red Cell Membrane Transport in Health and Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05181-8_30

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  • DOI: https://doi.org/10.1007/978-3-662-05181-8_30

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