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Disorders of Band 3

  • Petr Jarolim
Chapter

Abstract

Band 3 is the most abundant protein of the red blood cell (RBC) membrane and plays multiple structural and functional roles. It is therefore no surprise that numerous mutations in the band 3 gene have been described and found to be associated with several erythroid phenotypes. In addition, band 3 is expressed in renal collecting ducts and a distinct group of band 3 mutations have been linked to the phenotype of distal renal tubular acidosis. In the following paragraphs, we will segregate band 3 defects according to the primarily affected tissue (erythroid vs. non-erythroid) and to the degree of band 3 deficiency caused by the mutations.

Keywords

Renal Tubular Acidosis Blood Group Antigen Hereditary Spherocytosis Membrane Skeleton Distal Renal Tubular Acidosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Petr Jarolim
    • 1
  1. 1.Department of Pathology, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA

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