Glucose Transport

  • Richard J. Naftalin
Chapter

Abstract

Since I last wrote a review on this topic 25 years ago (Naftalin and Holman 1977) the dominant advance in our understanding of sugar transport has come from the publication of the amino acid sequence of the glucose transporters (GLUTs) with the 2D topology of the transporter in the membrane (Mueckler et al. 1985). Corroboration of the details of this 2D structure has been a major and continuing effort. Unfortunately, there has not been a commensurate increase in understanding of the mechanism of sugar transport. Although some advance in our perceptions of the mechanism of sugar transport has occurred, until recently, this has only been tenuously related to the transporter structure. Real advances can only come from knowledge of the 3D structural changes in GLUT, which accompany transport.

Keywords

Trypsin Oestradiol Cytosol Nifedipine Dystonia 

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© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Richard J. Naftalin
    • 1
  1. 1.Physiology DivisionKing’s College LondonLondonUK

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