Abstract
An approach to the assessment of the limit of detection and the limit of quantitation using uncertainty calculation is discussed. The approach is based on the known evaluation of the limits of detection and quantitation as concentrations of the analyte equal to three and ten standard deviations of the blank response, respectively. It is shown that these values can be calculated as the analyte concentrations, for which relative expanded uncertainty achieves 66% and 20% of possible results of the analyte determination, correspondingly. For example, the calculation is performed for the validation of a new method for water determination in the presence of ene-diols or thiols, developed for analysis of chemical products, drugs or other materials which are unsuitable for direct Karl Fischer titration. A good conformity between calculated values and experimental validation data is observed.
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References
Lauwaars M (1998) Accred Qual Assur 3: 32–35
USP 23 (1995) The United States Pharmacopeia (USP). The National Formulary. United States Pharmacopeia) Convention Inc, Md., USA
Kuselman I, Shenhar A (1995) Anal Chim Acta 306: 301–305
ISO/IEC Guide 25 (1990) General requirements for the competence of calibration and testing laboratories, 3d edn. International Organization for Standardization ( ISO ), Geneva
CITAC Guide 1 (1995) International guide to quality in analytical chemistry: An aid to accreditation, 1st edn. Teddington, UK
EURACHEM (1995) Quantifying uncertainty in analytical measurement, 1st edn. EURACHEM, Teddington, UK
Ellison SLS, Williams A (1998) Accred Qual Assur 3: 6–10
Kuselman I, Shenhar A (1997) Accred Qual Assur 2: 180–185
Wegscheider W (1997) The Proceedings of the 2nd EURACHEM Workshop “Measurement Uncertainty in Chemical Analysis. Current Practice and Future Directions”, 29–30 September, Berlin. EURACHEM
Dietrich A (1994) American Lab 26 (5): 33–39
Mitchell J Jr, Smith DM (1980) Aquametry, Part Ill (the Karl Fischer reagent). A treatise on methods for the determination of water. WilleyInterscience, N.Y., USA
Margolis SA (1995) Anal Chem 67: 4239–4246
Margolis SA (1997) Anal Chem 69: 4864–4871
Zeiler HJ, Heindl R, Wegscheider W (1996) Veitsch-Radex Rundschau 2: 48–55
Wegscheider W, Zeiler HJ, Heindl R, Mosser J (1997) Ann Chim 87: 273–283
Sherman F, Kuselman I, Shenhar A (1996) Talanta 43: 1035–1042
Sherman F, Kuselman I, Shenhar A (1998) Reagent for determining water and ene-diols or thiols. USA Patent No. 5,750,404, 12.05. 98
Kuselman I (1998) Accred Qual Assur 3: 131–133
Cedergren A (1996) Anal Chem 68: 3679–3681
American Public Health Association, American Water Works Association, Water Environment Federation (1995) Standard methods for the examination of water and wastewater, 19th edn. American Public Health Association, Washington, USA, pp 110, 1–11
Kaus R (1998) Accred Qual Assur 3: 150–154
Vogelgesang J, Hadrich J (1998) Accred Qual Assur 3: 242–255
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© 1999 Springer-Verlag Berlin Heidelberg
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Kuselman, I., Sherman, F. (1999). Assessment of limits of detection and quantitation using calculation of uncertainty in a new method for water determination. In: De Bièvre, P., Günzler, H. (eds) Measurement Uncertainty in Chemical Analysis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05173-3_45
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DOI: https://doi.org/10.1007/978-3-662-05173-3_45
Publisher Name: Springer, Berlin, Heidelberg
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