Echocardiography shares the same principles present in nature in the sonar of bats and dolphins. These animals send out an ultrasonic signal and — based on the arrival time of the reflected ultrasound wave — can detect reflecting structures, locate them in space, and perceive their form and motion. However, animal sonar has a greater potential than is dreamt of in commercially available instruments, since bats and dolphins can differentiate edible from inedible reflecting structures . From the captured echo, they extract information on the internal composition of the target. In the same way, the underlying hypothesis in tissue characterization studies is that a different biochemical structure or internal architectural arrangement of normal versus diseased tissue can affect the physical properties of the tissue and can therefore be detected by ultrasound .
KeywordsKawasaki Disease Cyclic Variation Tissue Characterization Carotid Atherosclerotic Plaque Integrate Backscatter
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- 1.Picano E, Landini L, Urbani MP, et al (1994) Ultrasound tissue characterization techniques for the evaluation of the plaque structures. Am J Cardiac Imaging 8:123–128Google Scholar
- 4.Glueck RM, Mottely JG, Miller JG, et al (1986) Intramyocardial variability in integrated backscatter. Effects of coronary occlusion and reperfusion. Circulation 75:436–442Google Scholar
- 20.Iwakura K, Ito H, Nishikawa N, et al (2000) Use of echocardiography for predicting myocardial viability in patients with reperfused anterior wall myocardial infarction. Am J Cardiol 85744–748Google Scholar
- 23.Falk E (1992) Why do plaques rupture? Circulation 86:11130–42Google Scholar
- 32.Kawasaki M, Takatsu H, Noda T, et al (2001) Noninvasive quantitative tissue characterization and two-dimensional color-coded map of human atherosclerotic lesions using ultrasound integrated backscatter. Comparison between histology and integrated backscatter images before and after death. J Am Coll Cardiol 38:486–492PubMedCrossRefGoogle Scholar
- 33.Noguchi T, Yasuda S, Akiyama Y et al (2003) Quantitative tissue characterization of vulnerable plaques in carotid artery by ultrasonic backscatter analysis. J Am Coll Cardiol 42:610–618Google Scholar