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Trends in Microfluidic Devices for Analytical Chemistry

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Book cover Biochips

Part of the book series: Biological and Medical Physics Series ((BIOMEDICAL))

Abstract

This chapter reviews recent advances and future trends in microfluidic devices for analytical chemistry. Microfluidic devices consisting of microchannel networks have offered an exclusive opportunity for performing massive parallel analysis with an integrated chip of a few cm. The microfluidic technique has yet to be a landmark in analytical chemistry, just like the role of the electronic chip in computer development. This review chapter consists of six sections: (1) introduction, (2) flow control, (3) sample handling, (4) separation, (5) microfluidic devices for electrospray ionisation mass spectrometry, (6) conclusions and outlook. Stress is laid on biomedical applications.

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References

  1. Ahn CH, Puntambekar A, Lee SM, Cho HJ and Hong C-C (2000) Proc. µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 205

    Google Scholar 

  2. Anazawa T, Takahashi S and Kambara H (1996) Anal Chem 68: 699

    Article  Google Scholar 

  3. Arora A, Mello AJ de and Manz A (1997) Analytical Communications 34: 393

    Article  Google Scholar 

  4. Barker SLR, Tarlov MJ, Branham M, Xu J, MacCrehan W, Gaitan M and Locascio L E (2000) Proc. µTAS 2000 Symposium. In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 67

    Google Scholar 

  5. Berg A van den (2000) Proc. µTAS 2000 Symposium. In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp vii

    Google Scholar 

  6. Bessoth FG, deMello AJ and Manz A (1999) Anal Commun 36: 213

    Article  Google Scholar 

  7. Bings NH, Wang C, Skinner CD, Colyer CL, Thibault P and Harrison DJ (1999) Anal Chem 71: 3292

    Article  Google Scholar 

  8. Braithwaite A and Smith FJ (1996) Chromatographic Methods 5`h Ed. Blackie Academic Professional, Glassgow, pp 33, 276, 357

    Google Scholar 

  9. Bruin GJM, Tock PPH, Kraak JC and Poppe H (1990) J Chromatogr 517: 557

    Article  Google Scholar 

  10. Ceriotti L, Verpoorte E and Rooij NF de (2000) Proc. µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 225

    Google Scholar 

  11. Cheng J, Sheldon EL, Wu L, Uribe A, Germe LO, Heller M and O’Connell J (1998) Nat Biotech 16: 541

    Article  Google Scholar 

  12. Cheng J, Waters LC, Fortina P, Hvichia G, Jacobson SC, Ramsey JM, Kricka LJ and Wilding P (1998) Anal Biochem 257: 101

    Article  Google Scholar 

  13. Cohen CB, Chin-Dixon E, Jeong S and Nikiforov TT (1999) Anal Biochem 273: 89

    Article  Google Scholar 

  14. Cole RB (ed) (1997) Electrospray Ionization Mass Spectrometry John Wiley Sons, New York

    Google Scholar 

  15. Crabtree HJ, Kopp MU and Manz A (1999) Anal Chem 71: 2130

    Article  Google Scholar 

  16. Culbertson CT, Jacobson SC and Ramsey JM (1998) Anal Chem 70: 3781

    Article  Google Scholar 

  17. Culbertson CT, Jacobson SC and Ramsey JM (2000) Proc µTAS 2000 Symposium. In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 221

    Google Scholar 

  18. Deshpande M, Greiner KB, West J, Gilbert JR, Bousse L and Minalla A (2000) Proc µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 339

    Google Scholar 

  19. Duffy DC, McDonald JC, Schueller OJA and Whitesides GM (1998) Anal Chem 70: 4974

    Article  Google Scholar 

  20. Effenhauser CS, Bruin GJM, Paulus A and Ehrat M (1997) Anal Chem 69: 3451

    Article  Google Scholar 

  21. Effenhauser CS, Manz A and Widmer HM (1993) Anal Chem 65: 2637

    Article  Google Scholar 

  22. Effenhauser CS, Paulus A, Manz A and Widmer HM (1994) Anal Chem 66: 2949

    Article  Google Scholar 

  23. Ehrlich DJ and Matsudaira P (1999) TIBTECH 17: 315

    Article  Google Scholar 

  24. Eijkel JCT, Mello A J de and Manz A (1999) Organic Mesoscopic Chemistry. In: Masuhara H and Schryver FC de (eds) Blackwell, Oxford, pp 185

    Google Scholar 

  25. Eijkel JCT, Stoeri H and Manz A (1999) Anal Chem 71: 2600

    Article  Google Scholar 

  26. Erbacher C, Bessoth FG, Busch M, Verpoorte E and Manz A (1999) Mikrochim. Acta, 131: 19

    Article  Google Scholar 

  27. Ericson C, Holm J, Ericson T and Hjertén S (2000) Anal Chem 72: 81

    Article  Google Scholar 

  28. Feng B and Smith RD (2000) J Am Soc Mass Spectr 11: 94

    Article  Google Scholar 

  29. Figeys D and Aebersold R (1998) Anal Chem 70: 3721

    Article  Google Scholar 

  30. Figeys D, Gygi SP, McKinnon G and Aebersold R (1998) Anal Chem 70: 3728 Fintschenko Y, Ngola SM, Shepodd TJ and Arnold DW (2000) Proc. µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 411

    Google Scholar 

  31. Frye-Mason G, Kottenstette R, Lewis P, Heller E, Manginell R, Adkins D, Dulleck G, Martinez D, Sasaki D, Mowry C, Matzke C and Anderson L (2000) Proc. µTAS 2000

    Google Scholar 

  32. Symposium. In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 229

    Google Scholar 

  33. Gao Q, Pang H-M and Yeung ES (1999) Electrophoresis 20: 1518

    Article  Google Scholar 

  34. Gao Q and Yeung ES (2000) Anal Chem 72: 2499

    Article  Google Scholar 

  35. Gelashvili DB, Tumanov AA, Bezrukov ME, Lisenkova NV, Barinova OV and Krest’yaninov PA (1999) J Anal Chem 54: 806

    Google Scholar 

  36. Gong X and Yeung ES (1999) Anal Chem 71: 4989

    Article  Google Scholar 

  37. Harrison DJ, Fluri K, Seiler K, Fan Z, Effenhauser CS and Manz A (1993) Science, 261: 895

    Article  ADS  Google Scholar 

  38. Harrison DJ, Manz A, Fan Z, Lüdi H and Widmer HM (1992) Anal Chem 64: 1926

    Article  Google Scholar 

  39. Harvey D (2000) Modern Analytical Chemistry McGraw-Hill, Boston

    Google Scholar 

  40. Hashimoto M, Tsukagoshi K, Nakajima R, Kondo K and Arai A (2000) J Chromatogr A867: 271

    Article  Google Scholar 

  41. He B, Ji J and Regnier FE (1999) J Chromatogr A853: 257

    Article  Google Scholar 

  42. He B and Regnier F (1998) J Pharm Biomed Anal 17: 925

    Article  Google Scholar 

  43. He B, Tait N and Regnier F (1998) Anal Chem 70: 3790

    Article  Google Scholar 

  44. He B, Tan L and Regnier F (1999) Anal Chem 71: 1464

    Article  Google Scholar 

  45. Heeren F von, Verpoorte E, Manz A and Thormann W (1996a) J Microcolumn Separat 8: 373

    Article  Google Scholar 

  46. Heeren F von, Verpoorte E, Manz A and Thormann W (1996b) Anal.Chem 68: 2044

    Google Scholar 

  47. Heiger DN (1992) High Performance Capillary Electrophoresis 2Ed, Hewlett-Packard, Waldbronn

    Google Scholar 

  48. Hofmann 0, Che D, Cruickshank KA and Müller UR (1999) Anal Chem 71: 678

    Article  Google Scholar 

  49. Holm J, GÖsch M, Blom H, Heino T, Thyberg P, BjÖrk G and Rigler R (2000) Proc. ‘,ETAS

    Google Scholar 

  50. Symposium. In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 273

    Google Scholar 

  51. Huang X, Coleman WF and Zare RNJ (1989) J Chromatogr 480: 95

    Article  Google Scholar 

  52. Huang XC, Quesada MA and RA Mathies (1992) Anal Chem 64: 2149

    Article  Google Scholar 

  53. Hutt LD, Glavin AP, Bada JL and RA Mathies (1999) Anal Chem 71: 4000

    Article  Google Scholar 

  54. Ishizuka N, Minakuchi H, Nakanishi K, Soga N, Nagayama H, Hosoya K and Tanaka N (2000) Anal Chem 72: 1275

    Article  Google Scholar 

  55. Jacobson SC, Ermakov SV and Ramsey JM (1999) Anal Chem 71: 3273

    Article  Google Scholar 

  56. Jacobson SC, McKnight TE and Ramsey JM (1999) Anal Chem 71: 4455

    Article  Google Scholar 

  57. Jakeway SC, Mello AJ de and Russell EL, Fresenius J (2000) Anal Chem 66: 525

    Google Scholar 

  58. Jiang G, Attiya S, Pcvirk G, Lee WE and Harrison DJ (2000) Biosensors Bioelectronics 14: 861

    Article  Google Scholar 

  59. Jo B-H, Moorthy J and Beebe DJ (2000) Proc µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 335

    Google Scholar 

  60. Kang SH, Gong X and Yeung ES (2000) Anal Chem 72: 3014

    Article  Google Scholar 

  61. Khandurina J, Jacobson SC, Waters LC, Foote RS and Ramsey JM (1999) Anal Chem 71: 1815

    Article  Google Scholar 

  62. Kopf-Sill AR (2000) Proc. OAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 233

    Google Scholar 

  63. Kopp MU, Mello Al de and Manz A (1998) Science 280: 1046

    Article  ADS  Google Scholar 

  64. Krejci M, Pechan Z and Deyl Z (1975) Liquid Column Chromatograpgy In: Deyl Z, Macek K andJanak J (eds) Elsevier, Amsterdam, pp 125

    Google Scholar 

  65. Krylov SN and Dovichi NJ (2000) Anal Chem 72: 111R

    Article  Google Scholar 

  66. Kutter JP, Jacobson SC and Ramsey JM (1997) Anal Chem 69: 5165

    Article  Google Scholar 

  67. Kutter JP, Jacobson SC, Mastubara N and Ramsey JM (1998) Anal Chem 70: 3291

    Article  Google Scholar 

  68. Kutter JP (2000) Trends in Anal Chem 19: 352

    Article  MathSciNet  Google Scholar 

  69. Kwok YC and Manz A (2000) Electrophoresis, submitted

    Google Scholar 

  70. Kwok YC and Manz A, in preparation

    Google Scholar 

  71. Lagally ET, Simpson PC and Mathies RA (2000) Sensors Actuators B63: 138

    Article  Google Scholar 

  72. Lazar IM, Ramsey RS, Sundberg S and Ramsey JM (1999) Anal Chem 71: 3627

    Article  Google Scholar 

  73. Lehmann U, Krusemark O, Müller J, Vogel A and Binz D (2000) Proc. TAS 2000 Symposium In: A van den Berg, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 167

    Google Scholar 

  74. Lichtenberg J, Daridon A, Verpoorte E and Rooij NF de (2000) Proc. µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 307

    Google Scholar 

  75. Licklider L, Wang X-Q, Desai A, Tai Y-C and Lee TD (2000) Anal Chem 72: 367

    Article  Google Scholar 

  76. Li J, Kelly JF, Chemushevich I, Harrison DJ and Thibault P (2000) Anal Chem 72: 599

    Article  Google Scholar 

  77. Li J, Thibault P, Bings NH, Skinner CD, Wang C, Colyer C and Harrison JD (1999) Anal Chem 71: 3036

    Article  Google Scholar 

  78. Li J, Wang C, Kelly JF, Harrison DJ and Thibault P (2000) Electrophoresis 21: 198

    Article  Google Scholar 

  79. Linden H van der, Olthuis W and Bergveld P (2000) Proc µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 175

    Google Scholar 

  80. Liu H, Felten C, Xue Q, Zhang B, Jedrzejewski P, Karger BL and Foret F (2000) Anal. Chem 72: 3303

    Article  Google Scholar 

  81. Liu RH, Yu Q, Bauer JM, Jo B-H, Moore JS and Beebe DJ (2000) Proc. µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 45

    Google Scholar 

  82. Liu S, Shi Y, Ja WW and Mathies RA (1999) Anal Chem 71: 566

    Article  Google Scholar 

  83. Liu Y, Foote RS, Jacobson SC, Ramsey RS and Ramsey JM (2000) Proc. µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 295

    Google Scholar 

  84. Liu Y and Kuhr WG (1999) Anal Chem 71: 1668

    Article  Google Scholar 

  85. MacNair JE, Patel KD and Jorgenson JW (1999) Anal Chem 71: 700

    Article  Google Scholar 

  86. Ma L, Gong X and Yeung ES (2000) Anal Chem 72: 3383

    Article  Google Scholar 

  87. Manz A, Grabe N and Widmer HM (1990) Sens Actuat Bl: 244

    Google Scholar 

  88. Manz A, Harrison DJ, Verpoorte E and Widmer HM (1993) Advances in Chromatography In: Brown PR and Crushka E (eds) Volume 33 Marcel Dekker, New York, pp 1

    Google Scholar 

  89. Manz A, Harrison DJ, Verpoorte EMJ, Fettinger JC, Paulus A, Lüdi H and Widmer HM (1992) J Chromatogr 593: 253

    Article  Google Scholar 

  90. Manz A, Miyahara Y, Miura J, Watanabe Y, Miyagi H and Sato K (1990) Sensors Actuators Bl: 249

    Google Scholar 

  91. Mao Q and Pawliszyn J (1999) Analyst 124: 637

    Article  ADS  Google Scholar 

  92. Marshell A and Hodgson J (1998) Nat Biotech 16: 37

    Article  Google Scholar 

  93. McEnery M, Tan A, Alderman J, Patterson J, O’Mathuna SC and Glennon JD (2000) Analyst 125: 25

    Article  ADS  Google Scholar 

  94. Mere L, Bennett T, Coassin P, England P, Hamman B, Rink T, Zimmerman S and Negulescu P (1999) DDT 4: 363

    Google Scholar 

  95. Mitchell MC, Spikmans V, Bessoth F, Manz A and Mello A de (2000) Proc. µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 463

    Google Scholar 

  96. Molho JI, Herr AE, Mosier BP, Santiago JG, Kenny TW, Brennen RA and Gordon GB (2000) Proc. µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 287

    Google Scholar 

  97. Mosher RA, Saville DA and Thormann W (1992) The Dynamics of Electrophoresis In: Radola BJ (ed) VCH, Weinheim, pp 11

    Google Scholar 

  98. Mueller O, Hahnenberger K, Dittmann M, Yee H, Dubrow R, Nagle R and Ilsley D (2000) Electrophoresis 21: 128

    Article  Google Scholar 

  99. Mullis KB, Ferre F and Gibbs RA (1994) The Polymerase Chain Reaction, Birkhauser, Boston

    Google Scholar 

  100. Nishimoto T, Fujiyama Y, Abe H, Kanai M, Nakanishi H and Arai A (2000) Proc. µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 395

    Google Scholar 

  101. Ocvirk G, Munroe M, Tang T, Oleschuk R, Westra K and Harrison DJ (2000) Electrophoresis 21: 107

    Article  Google Scholar 

  102. Ocvirk G, Verpoorte E, Manz A, Grasserbauer M and Widmer HM (1995) Anal Methods Instrum 2: 74

    Google Scholar 

  103. Oleschuk RD and Harrison DJ (2000) Trends in Anal Chem 19: 379

    Article  Google Scholar 

  104. Oleschuk RD, Shultz-Lockyear LL, Ning Y and Harrison DJ (2000) Anal Chem 72: 585

    Article  Google Scholar 

  105. Quirino JP, Terabe S and Bocek P (2000) Anal Chem 72: 1934

    Article  Google Scholar 

  106. Paegel BM, Hutt LD, Simpson PC and Mathies RA (2000) Anal Chem 72: 3030

    Article  Google Scholar 

  107. Prazen BJ, Bruckner CA, Synovec RE and Kowalski BR (1999) Anal Chem 71:1093 Preisler J and Yeung ES (1996) Anal Chem 68: 2885

    Google Scholar 

  108. Prest JE, Baldock SJ, Bektas N, Fielden PR and Brown BJT (1999) J Chromatogr A 836: 59

    Article  Google Scholar 

  109. Ramseier A, Heeren F von and Thormann W (1998) Electrophoresis 19:2967 Ramsey RS and Ramsey JM (1997) Anal Chem 69: 1174

    Google Scholar 

  110. Rodriguez-Diaz R, Wehr T and Zhu M (1997) Electrophoresis 18: 2134

    Article  Google Scholar 

  111. Salas-Solano O, Schmalzing D, Koutny L, Buonocore S, Adourian A, P Matsudaira and D Ehrlich (2000) Anal Chem 72: 3129

    Article  Google Scholar 

  112. Salimi-Moosavi H, Jiang YT, Lester L, McKinnon G and Harrison DJ (2000) Electrophoresis 21: 1291

    Article  Google Scholar 

  113. Sanders GHW and Manz A (2000) Trends in Anal Chem 19: 364

    Article  Google Scholar 

  114. Schmalzing D, Adourian A, Koutny L, Ziaugra L, Matsudaira P and Ehrlich D (1998) Anal Chem 70: 2303

    Article  Google Scholar 

  115. Schmalzing D, Koutny L, Chisholm D, Adourian A, Matsudaira P and Ehrlich D (1999) Anal Biochem 270: 148

    Article  Google Scholar 

  116. Schrum DP, Culbertson CT, Jacobson SC and Ramsey JM (1999) Anal Chem 71: 173

    Article  Google Scholar 

  117. Severs JC and Smith RD (1997) Anal Chem 69: 2154

    Article  Google Scholar 

  118. Shi Y, Simpson PC, Scherer JR, Wexler D, Skibola C, Smith MT and Mathies RA (1999) Anal Chem 71: 5354

    Article  Google Scholar 

  119. Simpson PC, Roach D, Woolley AT, Thorsen T, Johnston R, Sensabaugh GF and Mathies RA (1998) Proc. Natl Acad Sci 95: 2256

    Google Scholar 

  120. Sirichai S and Mello A J de (2000) Analyst 125: 133

    Article  ADS  Google Scholar 

  121. Smith N and Evans MB (1999) J Chromatogr A32: 41

    Google Scholar 

  122. Smith RD, Wahl JH, Goodlett DR and Hofstadler SA (1993) Anal Chem A 65: 574 Sullivan MG, Utomo H, Fagan PJ and Ward MD (1999) Anal Chem 71: 4369 [102]

    Google Scholar 

  123. Swanson P, Gelbart R, Atlas E, Yang L, Grogan T, Bulter WF, Ackley DE and Sheldon E (2000) Sens Actuat B64: 22

    Article  Google Scholar 

  124. Tantra R and Manz A (2000) Anal Chem 72: 2875

    Article  Google Scholar 

  125. Tashiro K, Sekiguchi T, Shoji S, Funatsu T, Masumoto W and Sat Ho (2000) Proc. µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 209

    Google Scholar 

  126. Terrett NK (1998) Combinatorial Chemsitry, Oxford University Press, Oxford Terry SC, Jerman JH, Angell JB (1979) IEEE Trans Electron Devices ED-26: 1880

    Google Scholar 

  127. Thormann W, Zhang C-X, Caslayska J, Gebauer P and Mosher RA (1998) Anal Chem 70: 549

    Article  Google Scholar 

  128. Tian H, Jaquins-Gerstl A, Munro N, Trucco M, Brody LC and Lander JPs (2000) Genomics 63: 25

    Article  Google Scholar 

  129. Todd MD, Lin XD, Stankowski LF, Desai M and Wolfgang GHI (1999) J Biomed Screening 4: 259

    Article  Google Scholar 

  130. Ueno K and Yeung ES (1994) Anal Chem 66: 1424

    Article  Google Scholar 

  131. Unger MA, Chou H-P, Thorsen T, Scherer A and Quake SR (2000) Science 288: 113

    Article  ADS  Google Scholar 

  132. Venter JG, Adams MD, Sutton GG, Kerlavage AR, Smith HO and Hunkapiller M (1998) Science 280: 1540

    Article  Google Scholar 

  133. Verpoorte EMJ, Schoot BH van der, Jeanneret S, Manz A, Widmer HM and de Rooij NF (1994) J Micromech Microeng 4: 246

    Article  Google Scholar 

  134. Vo-Dinh T, Alarie JP, Isola N, Landis D, Wintenberg AL and Ericson MN (1999) Anal Chem 71: 358

    Article  Google Scholar 

  135. Wahl JH, Gale DC and Smith RD (1994) J Chromatogr A659: 217

    Article  Google Scholar 

  136. Wallenborg SR and Bailey CG (2000) Anal Chem 72: 1872

    Article  Google Scholar 

  137. Wang J, Chatrathi MP and Tian B (2000) Analytical Chimica Acta 416: 9

    Article  Google Scholar 

  138. Waterston R and Sulston J E (1998) Science 282 53

    Article  ADS  Google Scholar 

  139. Wen J, Lin Y, Xiang F, Matson DW, Udseth HR and Smith RD (2000) Electrophoresis 21: 191

    Article  Google Scholar 

  140. Wilding P, Kricka, LJ, Cheng J, Hvichia G, Shoffner MA and Fortina P (1998) Anal Biochem 257: 95

    Article  Google Scholar 

  141. Woias P, Hauser K and Yacoub-George E (2000) Proc. µTAS 2000 Symposium In: Berg A van den, Olthuis W and Bergveld P (eds) Kluwer Academic Publishers, Dordrecht, pp 277

    Google Scholar 

  142. Woolley AT, Sensabaugh GF and Mathies RA (1997) Anal Chem 69: 2181

    Article  Google Scholar 

  143. Xiang F, Anderson GA, Veenstra TD, Lipton MS and Smith RD (2000) Anal Chem 72: 2475

    Article  Google Scholar 

  144. Xiang F, Lin Y, Wen J, Matson DW and Smith RD (1999) Anal Chem 71: 1485

    Article  Google Scholar 

  145. Xue Q, Foret F, Dunayevskiy YM, Zavracky PM, McGruer NE and Karger BL, (1997) Anal Chem 69: 426

    Article  Google Scholar 

  146. Xu Y, Bessoth FG, Eijkel JCT and Manz A (2000) Analyst 125: 677

    Article  ADS  Google Scholar 

  147. Zeng L and Kassel DB (1998) Anal Chem 70: 4380

    Article  Google Scholar 

  148. Zhang B, Foret F and Karger BL (2000) Anal Chem 72: 1015

    Article  Google Scholar 

  149. Zhang B, Liu H, Karger BL and Foret F (1999) Anal Chem 71: 3258

    Article  Google Scholar 

  150. Zhang C-X, Sun Z-P and Ling D-K (1993) J Chromatogr A655: 309

    Article  Google Scholar 

  151. Zhang C-X and Thormann W (1998) Anal Chem 70: 540

    Article  Google Scholar 

  152. Zhang C-X and Thormann W (1996) Anal Chem 68: 2523

    Article  Google Scholar 

  153. Zhang C-X, Xiang F, Paga-ToliC L, Anderson GA, Veenstra TD and Smith RD, (2000) Anal Chem 72: 1462

    Google Scholar 

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Zhang, C.X., Manz, A. (2003). Trends in Microfluidic Devices for Analytical Chemistry. In: Xing, WL., Cheng, J. (eds) Biochips. Biological and Medical Physics Series. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05092-7_9

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  • DOI: https://doi.org/10.1007/978-3-662-05092-7_9

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