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BSE, Scrapie, and vCJD: Infectious Neurodegenerative Diseases

  • Conference paper
Neuroinflammation — From Bench to Bedside

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 39))

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Abstract

Transmissible spongiform encephalopathies (TSEs) are infectious progressive neurodegenerative disorders. TSEs are usually associated with the appearance of an abnormal insoluble and protease-resistant form of a normal host-encoded protein, the prion protein (PrP). Structurally the disease-associated abnormal form of PrP, termed PrPres or PrPSc, is characterised by a high beta-sheet content in contrast to the predominantly alpha-helical fold of normal PrP (Hope and Manson 1991; Caughey et al. 1998).

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  1. C. Riemer
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  2. D. Simon
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  3. S. Neidhold
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  4. J. Schultz
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  5. A. Schwarz
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  6. M. Baier
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Editors and Affiliations

  1. Max Delbrück Center for Molecular Medicine, Department of Neurosciences, Robert Roessle Str. 10, 13125, Berlin, Germany

    H. Kettenmann

  2. Preclinical Drug Research, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    G. A. Burton  & U. J. Moenning  & 

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Riemer, C., Simon, D., Neidhold, S., Schultz, J., Schwarz, A., Baier, M. (2002). BSE, Scrapie, and vCJD: Infectious Neurodegenerative Diseases. In: Kettenmann, H., Burton, G.A., Moenning, U.J. (eds) Neuroinflammation — From Bench to Bedside. Ernst Schering Research Foundation Workshop, vol 39. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05073-6_6

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  • DOI: https://doi.org/10.1007/978-3-662-05073-6_6

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