Sex-Specific Differences in the Control of Mammalian Gametogenesis: Vive la Difference!
The notion that the highly differentiated mammalian gametes would have gamete-specific genes that are important for their differentiation and function is almost self-evident. The structural components of these specialized cells, such as proteins in the acrosome, flagellum, and zona pellucida would be expected to and indeed do exhibit sexually dimorphic expression and function. This class of sex-specific genes is excluded from the following discussion. Rather, we will explore the roles of genes that by virtue of their common expression in both oocytes and spermatocytes or their conserved function in gametes across species might be expected to be important to germ cell function in mammals — yet have proven to defy our best predictions!
KeywordsRecombination Germinal Hunt Stein Tate
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- Albert B, Bray D, Lewis J, Raff M, Roberts K and Watson JD (1983) Molecular Biology of The Cell. Garland Publishing, Inc.Google Scholar
- Bachvarova R (1985) Gene expression during oogenesis and oocyte development in mammals. In: Developmental Biology. Eds. L. W. Browder. New York, pp 453–524.Google Scholar
- Bellve AR, Cavicchia JC, Millette CF, O’Brien DA, Bhatnagar YM and Dym M (1977) Spermatogenic cells of the prepuberal mouse. Isolation and morphological characterization. J Cell Biol 741: 68–85Google Scholar
- Eddy EM, Welch JE and O’Brian DA (1993) Gene expression during spermatogenesis. In: Mol Biol of the Reprod Syst. Eds. D. d. Kretser. San Diego, pp 181–232Google Scholar
- Liao C, Ravnik S, Zhang Q, Muhlrad S and Wolgemuth D (In preparation) Differential Expression of the A-type Cyclins during Cell Cycles in the Mouse Ovary.Google Scholar
- Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub MP, LeMeur M and Chambon P (1993) High postnatal lethality and testis degeneration in reti-Google Scholar
- noic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A 90: 7225–7229Google Scholar
- Mendelsohn C, Lohnes D, Decimo D, Lufkin T, LeMeur M, Chambon P and Mark M (1994) Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 120: 2749–2771Google Scholar
- Murphy M, Stinnakre MG, Senamaud-Beaufort C, Winston NJ, Sweeney C, Kubelka M, Carrington M, Brechot C and Sobczak-Thepot J (1997) Delayed early embryonic lethality following disruption of the murine cyclin A2 gene [published erratum appeared in Nat Genet 1999 Dec;23(4):481]. Nat Genet 15: 83–86CrossRefGoogle Scholar
- Propst F, Rosenberg MP, Jyer A, Kaul K and Vande Woude GF (1987) c-mos proto-oncogene RNA transcripts in mouse tissues: structural features, developmental regulation, and localization in specific cell types. Mol Cell Biol 7: 1629–1637.Google Scholar
- Russel LD, Ettlin R, Sinha Hikim AP and Clegg ED (1990) Histological and Histopathological Evaluation of the Testis. Cache River Press.Google Scholar
- Schultz RM (1986) Molecular aspects of mammalian oocytes growth and maturation. In: Experimental Approaches to Mammalian Embryonic Development. Eds. J. R. a. R. A. Pedersen. New York, Cambridge University Press, pp 195–237Google Scholar
- Winston N, Bourgain-Guglielmetti F, Ciemerych MA, Kubiak JZ, SenamaudBeaufort C, Carrington M, Brechot C and Sobczak-Thepot J (2000) Early development of mouse embryos null mutant for the cyclin A2 gene occurs in the absence of maternally derived cyclin A2 gene products. Dev Biol 223: 139–153.PubMedCrossRefGoogle Scholar