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Dynamic Epileptic Systems Versus Static Epileptic Foci?

  • S. A. Chkhenkeli
  • J. Milton
Part of the Biological and Medical Physics Series book series (BIOMEDICAL)

Abstract

In 1881 William R. Gowers published his seminal book “Epilepsy and Other Chronic Convulsive Disorders” [102] . Since that time a major emphasis in clinical epileptology has been determining the site of origin of the epileptic discharge. Indeed the concept that a very limited area of brain is capable of producing and maintaining the epileptic discharge forms the cornerstone of current neuro-surgery procedures that treat epilepsy by either total resection [191–208] or stereotactic destruction [191,209–221] of the offending cortical region. However, the limited success and even failure of epilepsy surgery in a number of patients has drawn attention to the possibility that the nature of epileptic generators may be much more sophisticated than initially suspected, especially in patients with long-standing medically refractory epilepsy [40,191,210,222–229] . This chapter reviews the reasons for failure of epilepsy surgery and introduces the concept of epileptic systems [191,230], i.e. networks involving many distinct regions of the brain that are active in the brains of patients with medically refractory epilepsy.

Keywords

Temporal Lobe Temporal Lobe Epilepsy Epilepsy Surgery Refractory Epilepsy Intractable Epilepsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • S. A. Chkhenkeli
  • J. Milton

There are no affiliations available

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