Abstract
From the very early stages of development of modern mass spectrometry, the value of its combination with chromatography was quickly recognized. The coupling of GC with MS was a natural evolution since they are both vapor phase techniques, and very quickly GC-MS has been accepted as a standard component of the organic analytical laboratory. It has taken considerably longer to achieve a satisfactory and all-purpose mode of HPLC-MS coupling. The difficulties with HPLC-MS were associated with the fact that vaporization of typically 1 ml/min from the HPLC translates into a vapor flow rate of approximately 500–1000 ml/min. Other difficulties related to the eluent composition as result of the frequent use of non-volatile modifiers, and the ionization of nonvolatile and thermally labile analytes. However, during the past few years commercial interfaces have been developed which have led to a broad applicability of HPLC-MS [1–3].
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Balogh MP (1997) LC-GC Int 10: 728
Smits R (1995) LC-GC Int 8: 92
Niessen WMA, Tinke AP (1995) J Chromatogr A703: 37
Dole M (1968) J Chem Phys 49: 2240
Horning EC (1974) J Chromat Sci 12: 725
Vestal ML, Ferguson GJ (1985) Anal Chem 57: 2373
Willoughby RC, Browner RF (1984) Anal Chem 56: 2626
Yergey AL, Edmonds CG, Lewis IAS, Vestal ML (1990) Liquid chromatography/mass spectrometry - techniques and applications. Plenum Press, New York
Arpino PJ (1990) Mass Spectrom Rev 9: 631
Arpino PJ (1992) Mass Spectrom Rev 11: 3
Behymer TD, Bellar TA, Budde WL (1990) Anal Chem 62: 1686
Voyksner RD, Smith CS, Knox PC (1990) Biomed Environ Mass Spectrom 19: 523
Sciex PE (1989) The API Book, Thornhill, Ontario
Whitehouse CM, Dreyer RN, Yamashita M, Fenn JB (1985) Anal Chem 57: 675
Fenn JB, Mann M, Meng CK, Wong SF, Whitehouse CM (1990) Mass Spectrom Rev 9: 37
Bruins AP, Covey TR, Henion JD (1987) Anal Chem 59: 2642
Vouros P, Wronka JW (1991) In: Barth HG, Mays JW (eds) Modern methods in polymer characterization. Wiley, New York,,Chap. 12
Vestal ML (1984) Science 226: 595
Vargo JD, Olson KL (1985) Anal Chem 57: 672
Vestal ML (1983) Mass Spectrom Rev 2: 447
Vargo JD, Olson KL (1986) J Chromatogr 353: 215
Prokai L, Simonsick WJ (1995) SEC with electrospray mass spectrometric detection. In: Provder T, Barth HG, Urban MW (eds) Chromatographic characterization of polymers. Hyphenated and multidimensional techniques. Adv Chem Ser 247, American Chemical Society, Washington, DC, Chapter 4
Prokai L, Simonsick WJ (1993) Rapid Commun Mass Spectrom 7: 853
Simonsick WJ (1993) Polym Mater Sci Eng 69: 412
Simonsick WJ, Ross CW (1996) Polym Prepr 37: 286
Prokai L, Myung SW, Simonsick WJ (1996) Polym Prepr 37: 288
Kemp TJ, Barton Z, Mahon A (1996) Polym Prepr 37: 305
Pasch H, Rode K (1995) J Chromatogr A699: 21
Danis PO, Saucy DA, Huby FJ (1996) Polym Prepr 37: 311
Danis PO, Huby FJ (1995) J Am Soc Mass Spectrom 6: 1112
Montaudo G, Garozzo D, Montaudo MS, Puglisi C, Samperi F (1995) Macromolecules 28: 7983
Montaudo MS, Puglisi C, Samperi F, Montaudo G (1998) Macromolecules 31: 3839
Pasch H, Trathnigg B (1998) HPLC of polymers. Springer, Berlin Heidelberg New York
Pasch H, Brinkmann C, Much H, Just U (1992) J Chromatogr 623: 315
Gorshkov AV, Much H, Becker H, Pasch H, Evreinov VV, Entelis SG (1990) J Chromatogr 523: 91
Gorshkov AV, Verenich SS, Evreinov VV, Entelis SG (1988) Chromatographia 26: 338
Adrian J, Braun D, Rode K, Pasch H (1999) Angew Makro-mol Chem 267: 73
Lee H, Lee W, Chang T, Choi S, Lee D, JI H, Nonidez WK, Mays JW (1999) Macromolecules 32: 4143
Pasch H, Brinkmann C, Gallot Y (1993) Polymer 34: 4099
Pasch H, Augenstein M (1993) Makromol Chem 194: 2533
Braun D, Esser E, Pasch H (1998) Int J Polym Char 4: 501
Pasch H (1997) Adv Polym Sci 128: 1
Krüger RP, Much H, Schulz G (1996) GIT Fachz Lab 4: 398
Just U, Krüger RP (1996) In: Auner N, Weis J (eds) Organosilicon chemistry II, VCH Weinheim
Montaudo G (1995) Rapid Commun Mass Spectrom 9: 1158
Montaudo G (1998) Proc 11th Int Symp Polym Anal Char, Santa Margerita Ligure, Italy
Krüger R-P, Much H, Schulz G (1996) Int J Polym Anal Charact 2: 221
Kottner N, Bublitz R, Klemm E (1996) Macromol Chem Phys 197: 2665
Räder H-J, Spickermann J, Kreyenschmidt M, Müllen K (1996) Macromol Chem Phys 197: 3285
Spickermann J, Räder H-J, Müllen K, Müller B (1996) Macromol Rapid Commun 17: 885
Montaudo G (1996) Polym Prepr ACS Div Polym Chem 37: 290
Montaudo G (1996) TRIP 4: 81
Braun D, Henze I, Pasch H (1997) Macromol Chem Phys 198: 3365
Pasch H, Deffieux A, Ghahary R, Schapacher M, Riquelurbet L (1997) Macromolecules 30: 98
Wachsen O, Reichert KH, Krüger RP, Much H, Schulz G (1997) Polym Degrad Stab 55: 225
Lo T-Y, Huang SK (1998) J Appl Polym Sci 68: 1621
Hunt SM, Derrick PJ, Sheil MM (1998) Eur Mass Spectrom 4: 475
Montaudo MS (1999) Macromol Symp 141: 95
Ihara E, Tanabe M, Nakayama Y, Nakamura A, Yasuda H (1999) Macromol Chem Phys 200: 758
Montag P (1999) CLB Chemie in Labor und Biotechnik 50: 253
Nielen MWF, Malucha S (1997) Rapid Commun Mass Spectrom 11: 1194
Montaudo MS, Puglisi C, Samperi F, Montaudo G (1998) Rapid Commun Mass Spectrom 12: 519
Gagel JJ, Biemann K (1986) Anal Chem 58: 2184
Gagel JJ, Biemann K (1987) Anal Chem 59: 1266
Wheeler LM, Willis JN (1993) Appl Spectrosc 47: 1128
Willis JN, Dwyer JL, Wheeler LM (1993) Polym Mat Sci 69: 120
Pasch H, Esser E, Montag P (1996) GIT Fachz Lab Chromatogr 16: 68
Willis TN, Wheeler L (1995) Use of a GPC-FTIR interface for polymer analysis. In: Provder T, Barth HG, Urban MW (eds) Chromatographic characterization of polymers. Hyphenated and multidimensional techniques. Adv Chem Ser 247, American Chemical Society, Washington, DC, Chapter 19
Chervet J-P, van den Broek R (1997) GIT Lab J Int Ed 1: 92
Product documentation Probot, bai GmbH, Lautertal, Germany
Liedke S, Kremser L, Allmaier G, Rizzi A, Roitinger A (2001) GIT BlOforum 24: 152
Esser E, Keil C, Braun D, Montag P, Pasch H (2000) Polymer 41: 4039
Falkenhagen J, Krüger R-P, Schulz G, Gloede J (2001) GIT Fachz Lab 45: 380
Böhmer V (1995) Angew Chem 107: 785
Gutsche CD (1998) Calixarenes revisited. In: Stoddart JF (ed) Monographs in supramolecular chemistry. Royal Society of Chemistry, Cambridge
Nielen MWF (1998) Anal Chem 70: 1563
Nielen MWF, Buijtenhuijs FA (2001) LC-GC Europe 14: 82
Nielen MWF, Malucha S (1997) Rapid Commun Mass Spectrom 11: 1194
Keil C, Esser E, Pasch H (2001) Macromol Mat Eng 286: 161
Li L, Wang APL, Coulson LD (1993) Anal Chem 65: 493
Caprioli RM (1990) Anal Chem 62: 477A
Murray KK, Russell DH (1993) Anal Chem 65: 2534
Murray KK, Lewis TM, Beeson MD, Russell DH (1994) Anal Chem 66: 1601
Murray KK, Russell DH (1994) J Am Soc Mass Spectrom 5: 1
Fei X, WEI G, Murray KK (1996) Anal Chem 68: 1143
Fei X, Murray KK (1996) Anal Chem 68: 3555
Nagra DS, Li L (1995) J Chromatogr A711: 235
Coulson LD, Nagra DS, Guo X, Whittal RM, Li L (1994) Appl Spectrosc 48: 1125
Whittal RM, Russon LM, Li L (1998) J Chromatogr A794: 367
Joos PE (1995) LC-GC Int 8: 92
Montaudo MS, Puglisi C, Samperi F, Montaudo G (1998) Rapid Commun Mass Spectrom 12: 519
Marziarz EP, Liu XM, Quinn ET, Lai YC, Ammon DM, Grobe GL (2002) J Am Soc Mass Spectrom 13: 170
Kassis CE, Desimone JM, Linton RW, Remsen EE, Lange GW, Friedman RM (1997) Rapid Commun Mass Spectrom 11: 1134
Dwyer J, Botten D (1997) Internat Lab 27: 13A
Zhan Q, Gusev A, Hercules DM (1999) Rapid Commun Mass Spectrom 13: 2278
Liu J, Loewe RS, McCullough RD (1999) Macromolecules 32: 5777
Montaudo MS, Montaudo G (1999) Macromolecules 32: 7015
Montaudo MS (2001) Macromolecules 34: 2792
Mengerink Y, Peters R, Dekoster CG, van der Wal S, Claessens HA, Cramers CA (2001) J Chromatogr A914: 131
Nielen MWF (1999) Mass Spectrom Rev 18: 309
Gusev AI (2000) Fresenius J Anal Chem 366: 691
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Pasch, H., Schrepp, W. (2003). Coupling of Liquid Chromatography and MALDI-TOF Mass Spectrometry. In: MALDI-TOF Mass Spectrometry of Synthetic Polymers. Springer Laboratory. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05046-0_7
Download citation
DOI: https://doi.org/10.1007/978-3-662-05046-0_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-07923-8
Online ISBN: 978-3-662-05046-0
eBook Packages: Springer Book Archive