Crustacean Neuromuscular Glutamatergic and GABAergic Channels with Some Comparison to Drosophila Channels
In crustacean muscle glutamate is the excitatory and GABA the inhibitory transmitter. The respective glutamatergic and GABAergic channels have been investigated in on-cell and excised patch-clamp recordings. The glutamatergic channels are compared to such channels in Drosophila larvae which have very similar characteristics. Based on the recordings, reaction schemes for glutamatergic and GABAergic channel types are proposed, and the conditions for generation of a quantal current event are discussed.
KeywordsPermeability Bicarbonate NMDA Acetylcholine Isoflurane
Unable to display preview. Download preview PDF.
- Colquhoun D, Ogden DC (1988) Activation of ion channels in the frog end-plate by high concentrations of acetylcholine. J Physiol (Lond) 395: 131–159Google Scholar
- Cull-Candy SG (1976) Two types of extrajunctional L-glutamate receptors in locust muscle fibres. J Physiol (Lond) 255: 449–464Google Scholar
- Kaila K, Pastemack M, Saarikoski J, Voipio J (1989) Influence of GABA-gated bicarbonate conductance on potential, current and intracellular chloride in crayfish muscle fibres. J Physiol (Lond) 416: 161–181Google Scholar
- Magleby KL, Stevens CF (1972) A quantitative description of end-plate currents. J Physiol (Lond) 223: 173–197Google Scholar
- Pamas I, Dudel J, Cohen I, Franke C (1984) Strengthening of synaptic contacts of an excitatory axon on elimination of a second excitatory axon innervating the same target. J Neurosci 4: 1912–1923Google Scholar
- Takeuchi A, Takeuchi N (1967) Anion permeability of the inhibitory post-synaptic membrane of the crayfish neuromuscular junction. J Physiol (Lond) 191: 575–590Google Scholar