A-Current Diversity: Differences in Channel Hardware or Second Messengers?
The pyloric network generates a rhythmic motor behavior that is continuously adaptive (Harris-Warrick et al. 1992). This patterned activity is based not only on synaptic connectivity, but also on the unique firing properties of the component neurons. There are many molecular devices that could establish different firing properties between neurons, ranging from relatively static mechanisms like differential gene expression, to more dynamic methods such as changes in ion channel phosphorylation states. The strategies involved most likely reflect elementary principles of the system. Defining these strategies for the pyloric network could provide insights into its dynamic nature.
KeywordsDopamine Tyrosine Quinone Carboxy Lester
Unable to display preview. Download preview PDF.
- Baro DJ, Levini RM, Kim MT, Willms AR, Lanning CC, Rodriguez HE, Harris-Warrick RM (1997) Quantitative single-cell-reverse transcription-PCR demonstrates that A-current magnitude varies as a linear function of shal gene expression in identified stomatogastric neurons. J Neurosci 17: 6597–6610PubMedGoogle Scholar
- Baro, D.J., Quinones, L., Lanning, CC, Harris-Warrick, R.M., and Ruiz, M. (2001) Stable differences in α-subunit gene expression cannot account for IA diversity in the components of a dynamic motor network, in pressGoogle Scholar
- Bowlby MR, Mendoza G, Hinson J, An WF, Cao J, Wardwell-Swanson J, Mattson KI, Rhodes KJ (1999) Modulation of Kv4-family K+ channels by a novel family of neuronal calcium sensor homologs. Soc Neurosci Abstr 25: 982Google Scholar
- Chandy CK GG (1995) Voltage-gated potassium channel genes. In: North RA (ed) Handbook of receptors and channels: ligand- and voltage-gated ion channels. CRC, Boca Raton, pp 1–71Google Scholar
- Connor JA (1975) Neural repetitive firing: a comparitve study of membrane properties of crustacean walking leg axons. J Neurophysiol 351: 922–932Google Scholar
- Derst C, Karschin A (1998) Review: evolutionary link between prokaryotic and eukaryotic K+ channels. J Exp Biol 201: 2791–2799Google Scholar
- Doliveira LC, Nawoschik SP, An WF, Bowlby MR, Trimmer JS, Rhodes KJ (1999) Effects of two novel neuronal calcium sensor homologs on surface expression of Kv4 a-subunits in COSI cells. Soc Neurosci Abstr 25: 982Google Scholar
- Harris-Warrick R, Marder E, Selverston A, Moulins M (eds) (1992) Cellular and synaptic properties in the crustacean stomatogastric nervous system. In: Dynamic biological networks. MIT Press, CambridgeGoogle Scholar
- Hartline D, Graubard K (1992) Cellular and synaptic properties in the crustacean stomatogastric nervous system. In: Harris-Warrick R, Marder E, Selverston A, Moulins M (eds) Dynamic biological networks. MIT Press, Cambridge, pp 31–85Google Scholar
- Miller JP (1980) Mechanisms underlying pattern generation in the lobster stomatogastric ganglion. University of California, San DiegoGoogle Scholar
- Qian Y, DeRubies D, Pfaffiinger PJ (1999) The N-terminal and C-terminal domain of voltage-dependent potassium channels are processed and may act as signaling molecules. Soc Neurosc Abstr 25: 531Google Scholar
- Shi G, Nakahira K, Hammond S, Rhodes KJ, Schechter LE, Trimmer JS (1996) β-subunits promote K channel surface expression through effects early in biosynthesis. Neuron 16: 843–852Google Scholar
- Yang EK, Alvira M, Levitan ES, Takimoto K (1999) Association of Kv4 family channels with β subunits. Soc Neurosci Abstr 25: 983Google Scholar