Name Reactions pp 379-379 | Cite as

Ugi reaction

  • Jie Jack Li


Four-component condensation (4CC) of carboxylic acids, C-isocyanides, amines, and oxo compounds to afford peptides. Cf. Passerini reaction.




  1. 1.
    Ugi, I. Angew. Chem., Int. Ed. Engt. 1962 1,8.Google Scholar
  2. 2.
    Ugi, I.; Lohberger, S.; Karl, R. In Comprehensive Organic Synthesis,Trost, B. M.; Fleming, 1. Eds, Pergamon: Oxford, 1991 Vol. 2,1083Google Scholar
  3. 3.
    Dömling, A.; Ugi, I. Angew. Chem., Int. Ed. 2000, 39, 3168.Google Scholar
  4. 4.
    Zimmer, R.; Ziemer, A.; Grunner, M.; Brüdgam, I.; Hartl, H.; Reissig, H.-U. Synthesis 2001, 1649.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

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