Name Reactions pp 269-269 | Cite as

Passerini reaction

  • Jie Jack Li

Abstract

Three-component condensation (3CC) of carboxylic acids, C-isocyanides, and oxo compounds to afford α-acyloxycarboxamides. Cf. Ugi reaction.

Keywords

Isocyanide 

References

  1. 1.
    Passerini, M. Gazz. Chim. Ital. 1921, 51, 126, 181.Google Scholar
  2. 2.
    Ferosie, I. Aldrichimica Acta 1971, 4, 21.Google Scholar
  3. 3.
    Ugi, I.; Lohberger, S.; Karl, R. In Comprehensive Organic Synthesis, Trost, B. M.; Fleming, I., Eds, Pergamon: Oxford, 1991, Vol. 2, p. 1083.Google Scholar
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    Ziegler, T.; Kaisers, H.-J.; Schlomer, R.; Koch, C. Tetrahedron 1999, 55, 8397.CrossRefGoogle Scholar
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    Banfi, L.; Guanti, G.; Riva, R. Chem. Commun. 2000, 985.Google Scholar
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    Semple, J. E.; Owens, T. D.; Nguyen, K.; Levy, O. E. Org . Lett. 2000, 2, 2769.CrossRefGoogle Scholar
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    Owens, T. D.; Semple, J. E. Org . Lett. 2001, 3, 3301.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

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