Bamford-Stevens reaction

  • Jie Jack Li

Abstract

The Bamford-Stevens reaction and the Shapiro reaction share a similar mechanistic pathway. The former uses a base such as Na, NaOMe, LiH, NaH, NaNH2, etc., whereas the latter employs a base such as alkyllithiums and Grignard reagents. As a result, the Bamford-Stevens reaction furnishes the more-substituted olefins as the thermodynamic products, while the Shapiro reaction generally affords the less-substituted olefins as the kinetic products.

Keywords

NaOMe NaNH2 

References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Jie Jack Li
    • 1
  1. 1.Chemistry DepartmentPfizer Global Research and DevelopmentAnn ArborUSA

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