Systemic Lupus Erythematosus

  • Hans G. Fassbender


Systemic lupus erythematosus (SLE) is a systemic immunodisease of the connective tissue in which mainly the skin, joints, kidneys, nervous system, and serosal membranes are affected. SLE owes its inclusion in the heterogeneous group of “rheumatic”diseases to the joint involvement which does not, however, constitute the main focus of the disease. On the other hand, the rheumatic cycle is enriched by SLE, a disease in which there is no doubt about the pathogenetic importance of the autoantibodies which, in other diseases, are often only a doubtful or meaningless epiphenomenon. Typical features of SLE are antinuclear antibodies (ANAs) which occur in 90% of the patients.


Systemic Lupus Erythematosus Immune Complex Systemic Lupus Erythematosus Patient Pathological Manifestation Membranous Glomerulonephritis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Hans G. Fassbender
    • 1
  1. 1.Zentrum für Rheuma-PathologieMainzGermany

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