Regulatory aspects of evaluating combination treatments in autoimmune diseases

  • Pekka Kurki


Thus far, attempts to control major autoimmune diseases by solo therapy have not been very successful in the prevention of end organ damage. Toxicity of long-term solo therapy is a dose-limiting factor with many agents, such as cytotoxic agents, other immunosuppressive agents and corticosteroids [7]. Combination therapies with existing therapeutic agents may be necessary for better control of autoimmune diseases.


Rheumatoid Arthritis Autoimmune Disease Medicinal Product Marketing Authorisation Regulatory Aspect 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  1. 1.Department of PharmacologyNational Agency for MedicinesHelsinkiFinland

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